Annotations: 6LXD

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00636	Ribonuclease III domain (Ribonuclease_3)	Ribonuclease III domain	-	Family
A	PF00035	Double-stranded RNA binding motif (dsrm)	Double-stranded RNA binding motif	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five d ...	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.	Domain
A	PF14622	Ribonuclease-III-like (Ribonucleas_3_3)	Ribonuclease-III-like	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ribonuclease 3	SMAD binding protein binding binding R-SMAD binding lipid binding lipopolysaccharide binding carbohydrate derivative binding RNA binding primary miRNA binding organic cyclic compound binding nucleic acid binding identical protein binding protein homodimerization activity protein dimerization activity SMAD binding protein binding binding R-SMAD binding lipid binding lipopolysaccharide binding carbohydrate derivative binding RNA binding primary miRNA binding organic cyclic compound binding nucleic acid binding identical protein binding protein homodimerization activity protein dimerization activity enzyme binding DEAD/H-box RNA helicase binding ribonuclease III activity double-stranded RNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity cation binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process pre-miRNA processing negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process negative regulation of metabolic process primary metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing organic cyclic compound metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing ncRNA metabolic process miRNA metabolic process ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process nucleic acid catabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response multicellular organismal process regulation of leukocyte differentiation cellular developmental process regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development T cell activation cell differentiation anatomical structure development T cell differentiation regulation of immune system process regulation of multicellular organismal process developmental process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis regulation of regulatory T cell differentiation cell activation regulation of T cell activation immune system process regulatory T cell differentiation regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation primary miRNA processing biological process involved in interspecies interaction between organisms response to other organism defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus regulation of primary metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process defense response to Gram-positive bacterium	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol nucleoplasm synapse cell junction glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse microprocessor complex protein-containing complex catalytic complex nuclear protein-containing complex endonuclease complex endoribonuclease complex ribonuclease III complex intracellular protein-containing complex
B, C	Microprocessor complex subunit DGCR8	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding tetrapyrrole binding heme binding primary miRNA binding cation binding ion binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding tetrapyrrole binding heme binding primary miRNA binding cation binding ion binding metal ion binding small molecule binding protein-RNA adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of stem cell proliferation regulation of biological process stem cell proliferation cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation cellular process pre-miRNA processing negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process positive regulation of post-transcriptional gene silencing regulation of stem cell proliferation regulation of biological process stem cell proliferation cell population proliferation regulation of cellular process regulation of cell population proliferation biological regulation cellular process pre-miRNA processing negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process positive regulation of post-transcriptional gene silencing nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of post-transcriptional gene silencing by RNA positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of miRNA processing negative regulation of cellular biosynthetic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound metabolic process miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing miRNA processing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of pre-miRNA processing cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process regulation of miRNA-mediated gene silencing organic substance metabolic process regulation of regulatory ncRNA processing positive regulation of miRNA-mediated gene silencing regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of miRNA processing positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression positive regulation of pre-miRNA processing positive regulation of cellular biosynthetic process primary miRNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse microprocessor complex protein-containing complex catalytic complex nuclear protein-containing complex endonuclease complex endoribonuclease complex ribonuclease III complex intracellular protein-containing complex nuclear body nucleoplasm glutamatergic synapse
D	RNA (102-mer)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR044442	RNase III, double-stranded RNA binding domain, animal	Domain
A	IPR011907	Ribonuclease III	Family
A	IPR000999	Ribonuclease III domain	Domain
A	IPR036389	Ribonuclease III, endonuclease domain superfamily	Homologous Superfamily
A	IPR014720	Double-stranded RNA-binding domain	Domain
B, C	IPR040375	Microprocessor complex subunit DGCR8	Family
B, C	IPR036020	WW domain superfamily	Homologous Superfamily
B, C	IPR001202	WW domain	Domain
B, C	IPR014720	Double-stranded RNA-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NRR4	kidney Wilms tumor male infertility Bilateral Wilms Tumor pancreatic intraductal papillary-mucinous neoplasm cancer lymphoplasmacytic lymphoma medulloblastoma schizophrenia dermatomyositis ovarian cancer
B, C	Pharos: Q8WYQ5	DiGeorge syndrome kidney Wilms tumor schizophrenia Behavior Disorders cystic fibrosis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psychiatric disorder depressive disorder ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia velocardiofacial syndrome pancreatic intraductal papillary-mucinous carcinoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.