Annotations: 6LUM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth B]	d6lumb2	All alpha proteins	Globin-like	alpha-helical ferredoxin	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)
E [auth B]	d6lumb1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)
J [auth K]	d6lumk2	All alpha proteins	Globin-like	alpha-helical ferredoxin	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)
J [auth K]	d6lumk1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)
O [auth Q]	d6lumq2	All alpha proteins	Globin-like	alpha-helical ferredoxin	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)
O [auth Q]	d6lumq1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Mycolicibacterium smegmatis MC2 51 ) [TaxId: 1445611 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF01127	e6lumC1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
F [auth G]	PF01127	e6lumG1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
K [auth M]	PF01127	e6lumM1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
B [auth D]	PF01127	e6lumD1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
G [auth H]	PF01127	e6lumH1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
L [auth N]	PF01127	e6lumN1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Fumarate reductase respiratory complex transmembrane subunits	F: PF01127	ECOD (1.6)
D [auth A]	PF02910	e6lumA2	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: PF02910	ECOD (1.6)
D [auth A]	PF00890	e6lumA1	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: PF00890	ECOD (1.6)
D [auth A]	PF00890	e6lumA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
N [auth P]	PF02910	e6lumP1	A: alpha bundles	X: Spectrin repeat-like	H: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	F: PF02910	ECOD (1.6)
N [auth P]	PF00890	e6lumP2	A: a+b complex topology	X: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)	T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	F: PF00890	ECOD (1.6)
N [auth P]	PF00890	e6lumP3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF00890	ECOD (1.6)
E [auth B]	PF13237	e6lumB2	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: PF13237	ECOD (1.6)
E [auth B]	PF13085	e6lumB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF13085	ECOD (1.6)
J [auth K]	PF13237	e6lumK2	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: PF13237	ECOD (1.6)
J [auth K]	PF13085	e6lumK1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF13085	ECOD (1.6)
O [auth Q]	PF13237	e6lumQ1	A: alpha arrays	X: alpha-helical ferredoxin-like	H: alpha-helical ferredoxin (From Topology)	T: alpha-helical ferredoxin	F: PF13237	ECOD (1.6)
O [auth Q]	PF13085	e6lumQ2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF13085	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth B]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (utative)
E [auth B]	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (utative)
J [auth K]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (utative)
J [auth K]	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (utative)
O [auth Q]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (utative)
O [auth Q]	1.10.1060.10	Mainly Alpha	Orthogonal Bundle	Fumarate Reductase Iron-sulfur Protein	Chain B, domain 2	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], F [auth G], K [auth M]	PF01127	Succinate dehydrogenase/Fumarate reductase transmembrane subunit (Sdh_cyt)	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	Family
B [auth D], G [auth H], L [auth N]	PF01127	Succinate dehydrogenase/Fumarate reductase transmembrane subunit (Sdh_cyt)	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	Family
D [auth A], I [auth J], N [auth P]	PF02910	Fumarate reductase flavoprotein C-term (Succ_DH_flav_C)	Fumarate reductase flavoprotein C-term	This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.	Domain
D [auth A], I [auth J], N [auth P]	PF00890	FAD binding domain (FAD_binding_2)	FAD binding domain	-	Family
E [auth B], J [auth K], O [auth Q]	PF13085	2Fe-2S iron-sulfur cluster binding domain (Fer2_3)	2Fe-2S iron-sulfur cluster binding domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	Domain
E [auth B], J [auth K], O [auth Q]	PF13237	4Fe-4S dicluster domain (Fer4_10)	4Fe-4S dicluster domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], F [auth G], K [auth M]	Succinate dehydrogenase subunit C	electron transfer activity cation binding ion binding binding metal ion binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy	respiratory chain complex protein-containing complex intracellular anatomical structure catalytic complex succinate dehydrogenase complex membrane membrane protein complex cellular anatomical entity respiratory chain complex II respirasome oxidoreductase complex
B [auth D], G [auth H], L [auth N]	Succinate dehydrogenase subunit D	cation binding ion binding binding metal ion binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity	-	membrane cellular anatomical entity
C [auth E], H [auth I], M [auth O]	Succinate dehydrogenase subunit F	-	-	membrane cellular anatomical entity
D [auth A], I [auth J], N [auth P]	Succinate dehydrogenase subunit A	oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity succinate dehydrogenase (quinone) activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity succinate dehydrogenase (quinone) activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding steroid dehydrogenase activity steroid dehydrogenase activity, acting on the CH-CH group of donors	cellular metabolic process electron transport chain metabolic process cellular process generation of precursor metabolites and energy aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process	membrane cellular anatomical entity
E [auth B], J [auth K], O [auth Q]	Succinate dehydrogenase subunit B	iron-sulfur cluster binding binding 3 iron, 4 sulfur cluster binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding electron transfer activity cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], F [auth G], K [auth M]	IPR039023	Succinate dehydrogenase membrane subunit SdhC, prokaryotes	Family
A [auth C], F [auth G], K [auth M]	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
A [auth C], F [auth G], K [auth M]	IPR000701	Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit	Family
A [auth C], F [auth G], K [auth M]	IPR014314	Succinate dehydrogenase, cytochrome b556 subunit	Family
B [auth D], G [auth H], L [auth N]	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
B [auth D], G [auth H], L [auth N]	IPR000701	Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit	Family
D [auth A], I [auth J], N [auth P]	IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal	Domain
D [auth A], I [auth J], N [auth P]	IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site	Binding Site
D [auth A], I [auth J], N [auth P]	IPR037099	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily	Homologous Superfamily
D [auth A], I [auth J], N [auth P]	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
D [auth A], I [auth J], N [auth P]	IPR003953	FAD-dependent oxidoreductase 2, FAD binding domain	Domain
D [auth A], I [auth J], N [auth P]	IPR030664	FAD-dependent oxidoreductase SdhA/FrdA/AprA	Family
D [auth A], I [auth J], N [auth P]	IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily	Homologous Superfamily
D [auth A], I [auth J], N [auth P]	IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	Family
D [auth A], I [auth J], N [auth P]	IPR011281	Succinate dehydrogenase, flavoprotein subunit	Family
E [auth B], J [auth K], O [auth Q]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
E [auth B], J [auth K], O [auth Q]	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal	Domain
E [auth B], J [auth K], O [auth Q]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
E [auth B], J [auth K], O [auth Q]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
E [auth B], J [auth K], O [auth Q]	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
E [auth B], J [auth K], O [auth Q]	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein	Family
E [auth B], J [auth K], O [auth Q]	IPR009051	Alpha-helical ferredoxin	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B [auth D], C [auth E], D [auth A], F [auth G] A [auth C], B [auth D], C [auth E], D [auth A], F [auth G], G [auth H], H [auth I], I [auth J], K [auth M], L [auth N], M [auth O], N [auth P]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex II superfamily	Succinate dehydrogenase/fumarate reductase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D], C [auth E], D [auth A], F [auth G] A [auth C], B [auth D], C [auth E], D [auth A], F [auth G], G [auth H], H [auth I], I [auth J], K [auth M], L [auth N], M [auth O], N [auth P]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D], C [auth E], D [auth A], F [auth G] A [auth C], B [auth D], C [auth E], D [auth A], F [auth G], G [auth H], H [auth I], I [auth J], K [auth M], L [auth N], M [auth O], N [auth P]	MemProtMD	Annotated as membrane protein by MemProtMD