Annotations: 6LT0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00400	e6lt0A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
D	PF00400	e6lt0D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
C, F	PF15019	C9orf72-like protein family (C9orf72-like)	C9orf72-like protein family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	WD repeat-containing protein 41	-	regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of transport secretion biological regulation export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis cellular process cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity response to stimulus immune response negative regulation of response to stimulus negative regulation of immune response regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of immune system process regulation of cellular metabolic process regulation of catabolic process regulation of autophagy regulation of cellular catabolic process regulation of metabolic process	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm organelle membrane lysosome protein-containing complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex
B, E	Guanine nucleotide exchange protein SMCR8	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity GTPase regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity protein binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity GTPase regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity protein binding binding kinase binding enzyme binding protein kinase binding guanyl-nucleotide exchange factor activity	regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of transport secretion biological regulation export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis cellular process cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of immune system process immune system process regulation of immune response regulation of immune system process regulation of TORC1 signaling TORC1 signaling negative regulation of cellular catabolic process macroautophagy regulation of autophagy negative regulation of cellular metabolic process negative regulation of catabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of catabolic process negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy regulation of cellular catabolic process regulation of metabolic process positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation protein-containing complex disassembly positive regulation of cellular metabolic process regulation of protein-containing complex disassembly cellular component organization positive regulation of metabolic process autophagosome maturation cellular component organization or biogenesis positive regulation of macroautophagy positive regulation of protein-containing complex disassembly cellular component disassembly positive regulation of autophagy protein-containing complex organization positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization positive regulation of cellular catabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process organic substance metabolic process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation negative regulation of organelle assembly autophagosome organization cellular component biogenesis cellular component assembly negative regulation of autophagosome assembly autophagosome assembly organelle assembly vacuole organization negative regulation of cellular component organization regulation of autophagosome assembly regulation of vacuole organization regulation of cellular component biogenesis negative regulation of organelle organization regulation of organelle assembly cellular biosynthetic process organic substance biosynthetic process regulation of biosynthetic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex intracellular anatomical structure catalytic complex serine/threonine protein kinase complex Atg1/ULK1 kinase complex cytoplasm cellular anatomical entity transferase complex presynapse synapse cell junction membrane-bounded organelle protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex intracellular anatomical structure catalytic complex serine/threonine protein kinase complex Atg1/ULK1 kinase complex cytoplasm cellular anatomical entity transferase complex presynapse synapse cell junction membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle guanyl-nucleotide exchange factor complex intracellular protein-containing complex postsynapse cell projection
C, F	Guanine nucleotide exchange C9orf72	small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of localization regulation of cellular process transport negative regulation of biological process negative regulation of transport vesicle-mediated transport localization negative regulation of secretion regulation of secretion by cell secretion by cell negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell regulation of biological process regulation of transport secretion biological regulation export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis regulation of exocytosis cellular process catabolic process regulation of cellular component organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process cellular component assembly cellular component organization or biogenesis process utilizing autophagic mechanism autophagosome assembly organelle assembly vacuole organization cellular metabolic process regulation of autophagosome assembly regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly metabolic process import into cell endocytosis positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity response to stimulus immune response negative regulation of response to stimulus negative regulation of immune response regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of immune system process cellular response to stimulus TOR signaling regulation of signaling regulation of TOR signaling signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of cell communication regulation of TORC1 signaling signal transduction TORC1 signaling regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process regulation of cytoskeleton organization regulation of actin filament organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization positive regulation of biological process positive regulation of cellular metabolic process regulation of autophagy positive regulation of metabolic process positive regulation of macroautophagy positive regulation of cellular process positive regulation of autophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process protein localization cellular localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization late endosome to lysosome transport establishment of localization in cell vacuolar transport intracellular transport lysosomal transport stress granule assembly non-membrane-bounded organelle assembly axon extension multicellular organismal process axonogenesis cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth membrane-bounded organelle nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system organelle envelope nuclear envelope organelle membrane cytosol presynapse synapse cell junction dendrite dendritic tree protein-containing complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex lytic vacuole vacuole lysosome main axon autophagosome endosome intracellular vesicle cytoplasmic vesicle vesicle Flemming body midbody P-body extracellular region extracellular space postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR019775	WD40 repeat, conserved site	Conserved Site
A, D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, D	IPR040102	WD repeat-containing protein 41	Family
A, D	IPR001680	WD40 repeat	Repeat
A, D	IPR020472	G-protein beta WD-40 repeat	Repeat
A, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B, E	IPR037520	Folliculin/SMCR8, longin domain	Domain
B, E	IPR037521	Folliculin/SMCR8, tripartite DENN domain	Domain
C, F	IPR027819	Guanine nucleotide exchange factor C9orf72	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: Q9HAD4	adrenal cortex carcinoma Pick disease osteosarcoma ovarian cancer
B, E	Pharos: Q8TEV9	attention deficit hyperactivity disorder, inattentive type osteosarcoma juvenile dermatomyositis ovarian cancer large cell medulloblastoma
C, F	Pharos: Q96LT7	amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 1 juvenile idiopathic arthritis frontotemporal dementia with motor neuron disease neurodegenerative disease Frontotemporal Lobar Degeneration behavioral variant of frontotemporal dementia inflammatory bowel disease malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma amyotrophic lateral sclerosis type 1 schizoaffective disorder aphasia amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 1 juvenile idiopathic arthritis frontotemporal dementia with motor neuron disease neurodegenerative disease Frontotemporal Lobar Degeneration behavioral variant of frontotemporal dementia inflammatory bowel disease malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma amyotrophic lateral sclerosis type 1 schizoaffective disorder aphasia sinusitis bipolar disorder Crohn disease gastric carcinoma intellectual disability ovarian cancer Parkinson disease Alzheimer disease progressive non-fluent aphasia schizophrenia atypical teratoid rhabdoid tumor tuberculosis brain disease dementia hepatocellular carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease semantic dementia ulcerative colitis breast cancer gastric cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.