6LKD

in meso full-length rat KMO in complex with a pyrazoyl benzoic acid inhibitor

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6lkdA1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF01494	e6lkdA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF01494	ECOD (1.6)
B	F_UNCLASSIFIED	e6lkdB2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF01494	e6lkdB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: PF01494	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01494	FAD binding domain (FAD_binding_3)	FAD binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kynurenine 3-monooxygenase	NAD(P)H oxidase H2O2-forming activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding NAD(P)H oxidase H2O2-forming activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding kynurenine 3-monooxygenase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	organonitrogen compound metabolic process benzene-containing compound metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process L-kynurenine metabolic process kynurenine metabolic process organic cyclic compound metabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process organonitrogen compound metabolic process benzene-containing compound metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process L-kynurenine metabolic process kynurenine metabolic process organic cyclic compound metabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process cellular ketone metabolic process metabolic process small molecule metabolic process cellular process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process quinolinate biosynthetic process organic substance biosynthetic process pyridine-containing compound metabolic process dicarboxylic acid biosynthetic process quinolinate metabolic process small molecule biosynthetic process dicarboxylic acid metabolic process pyridine-containing compound biosynthetic process biosynthetic process organic cyclic compound biosynthetic process aromatic amino acid metabolic process anthranilate metabolic process monocarboxylic acid metabolic process nucleotide biosynthetic process indole-containing compound metabolic process nucleobase-containing compound metabolic process phosphate-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process NAD biosynthetic process pyridine nucleotide biosynthetic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process nucleotide metabolic process tryptophan metabolic process nicotinamide nucleotide biosynthetic process amine metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process biogenic amine metabolic process purine nucleotide biosynthetic process NAD metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process 'de novo' NAD biosynthetic process indolalkylamine metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organophosphate metabolic process 'de novo' NAD biosynthetic process from tryptophan cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin monocarboxylic acid biosynthetic process kynurenic acid biosynthetic process kynurenic acid metabolic process response to cytokine cellular response to interleukin-1 cellular response to cytokine stimulus response to interleukin-1 regulation of localization nitrogen compound transport regulation of cellular process transport regulation of glutamate secretion positive regulation of biological process positive regulation of secretion by cell positive regulation of amine transport localization secretion by cell regulation of secretion by cell positive regulation of secretion regulation of amino acid transport glutamate secretion positive regulation of cellular process regulation of biological process organic anion transport carboxylic acid transport secretion regulation of transport organic substance transport biological regulation positive regulation of glutamate secretion export from cell establishment of localization regulation of secretion positive regulation of organic acid transport organic acid transport amino acid transport amine transport acidic amino acid transport positive regulation of transport positive regulation of amino acid transport regulation of organic acid transport dicarboxylic acid transport regulation of amine transport positive regulation of cell communication synaptic transmission, glutamatergic positive regulation of neurotransmitter secretion cell communication establishment of localization in cell trans-synaptic signaling positive regulation of neurotransmitter transport neurotransmitter secretion positive regulation of synaptic transmission neurotransmitter transport signal release from synapse glutamate secretion, neurotransmission positive regulation of glutamate secretion, neurotransmission regulation of trans-synaptic signaling cellular localization modulation of chemical synaptic transmission signaling regulation of synaptic transmission, glutamatergic L-amino acid transport L-glutamate import synaptic signaling signal release regulation of signaling regulation of neurotransmitter transport cell-cell signaling chemical synaptic transmission positive regulation of synaptic transmission, glutamatergic regulation of glutamate secretion, neurotransmission regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling response to osmotic stress response to stress response to abiotic stimulus response to salt stress catabolic process aromatic amino acid family catabolic process organic acid catabolic process cellular catabolic process carboxylic acid catabolic process amino acid catabolic process organonitrogen compound catabolic process organic cyclic compound catabolic process alpha-amino acid catabolic process indole-containing compound catabolic process tryptophan catabolic process small molecule catabolic process organic substance catabolic process	membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane cytoplasm organelle membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR027545	Kynurenine 3-monooxygenase	Family
A, B	IPR002938	FAD-binding domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				Kynurenine monooxygenase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Oxygenases	kynurenine 3-monooxygenase (KMO), full length, in complex with a pyrazoyl benzoic acid inhibitor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.