Annotations: 6LB8

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e6lb8B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6lb8D2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, C	PF13202	EF hand (EF-hand_5)	EF hand	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Endolysin,Calcium uptake protein 1, mitochondrial	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity identical protein binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process organic substance metabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process macromolecule metabolic process organic substance catabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism cellular process viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport calcium import into the mitochondrion monoatomic cation transport calcium ion transmembrane transport mitochondrial transport calcium ion import cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of mitochondrial calcium ion concentration cellular response to stimulus regulation of cellular hyperosmotic salinity response regulation of cellular process regulation of cellular response to stress cellular hyperosmotic salinity response cellular response to chemical stress response to salt stress regulation of response to osmotic stress cellular response to environmental stimulus hyperosmotic salinity response regulation of response to salt stress hyperosmotic response regulation of cellular response to osmotic stress cellular hyperosmotic response cellular response to stress regulation of response to stress response to osmotic stress regulation of biological process cellular response to salt stress biological regulation cellular response to osmotic stress cellular response to chemical stimulus regulation of response to stimulus response to chemical response to abiotic stimulus cellular response to abiotic stimulus	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen uniplex complex mitochondrial protein-containing complex inner mitochondrial membrane protein complex
B, D	Calcium uptake protein 2, mitochondrial	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport mitochondrial transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization import into the mitochondrion mitochondrial calcium ion transmembrane transport monoatomic ion transport cellular process calcium import into the mitochondrion monoatomic cation transport calcium ion transmembrane transport mitochondrial transport mitochondrial calcium ion homeostasis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis negative regulation of mitochondrial calcium ion concentration positive regulation of mitochondrial calcium ion concentration	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen uniplex complex mitochondrial protein-containing complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR001165	T4-type lysozyme	Family
A, C	IPR034690	Endolysin T4 type	Family
A, C	IPR002196	Glycoside hydrolase, family 24	Family
A, C	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, C	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A, C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, C	IPR039800	Calcium uptake protein 1/2/3	Family
A, C	IPR002048	EF-hand domain	Domain
A, C	IPR011992	EF-hand domain pair	Homologous Superfamily
B, D	IPR039800	Calcium uptake protein 1/2/3	Family
B, D	IPR002048	EF-hand domain	Domain
B, D	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q9BPX6	proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer proximal myopathy with extrapyramidal signs myopathy basal ganglia disease pancreatic intraductal papillary-mucinous carcinoma Adult Learning Disorders congenital muscular dystrophy muscle tissue disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis arthrogryposis learning disability movement disorder muscular disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability malignant glioma
B, D	Pharos: Q8IYU8	hereditary spastic paraplegia progressive supranuclear palsy lymphoplasmacytic lymphoma psoriasis ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.