Annotations: 6L54

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02260	FATC domain (FATC)	FATC domain	-	Family
A	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family
A	PF17229	Serine/threonine-protein kinase SMG1 N-terminal (SMG1_N)	Serine/threonine-protein kinase SMG1 N-terminal	-	Disordered
B	PF10220	Smg8_Smg9 (Smg8_Smg9)	Smg8_Smg9	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Serine/threonine-protein kinase SMG1	protein serine/threonine kinase activity diacylglycerol-dependent serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding protein serine/threonine kinase activity diacylglycerol-dependent serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding DNA binding telomeric DNA binding protein serine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization macromolecule localization macromolecule metabolic process regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of primary metabolic process cellular component organization nucleobase-containing compound metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process regulation of biological process biological regulation chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process DNA metabolic process regulation of organelle organization nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization regulation of metabolic process regulation of DNA metabolic process protein phosphorylation organonitrogen compound metabolic process protein autophosphorylation phosphorylation macromolecule modification protein metabolic process protein modification process DNA repair peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process negative regulation of metabolic process regulation of cellular metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromatoid body cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol chromatoid body cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	Protein SMG8	-	regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process regulation of biological process organonitrogen compound metabolic process regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process regulation of biological process organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process negative regulation of metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
C	Protein SMG9	identical protein binding protein binding binding	developmental process multicellular organism development multicellular organismal process sensory organ development eye development anatomical structure development animal organ development visual system development sensory system development system development head development central nervous system development brain development nervous system development developmental process multicellular organism development multicellular organismal process sensory organ development eye development anatomical structure development animal organ development visual system development sensory system development system development head development central nervous system development brain development nervous system development heart development circulatory system development regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR003152	FATC domain	Domain
A	IPR035175	Serine/threonine-protein kinase SMG1, N-terminal	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR039414	SMG1, PIKK catalytic domain	Domain
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR031559	Serine/threonine-protein kinase SMG1	Family
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR014009	PIK-related kinase	Domain
B	IPR019354	Nonsense-mediated mRNA decay factor SMG8-like	Family
C	IPR039177	Nonsense-mediated mRNA decay factor SMG9	Family
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96Q15	amyotrophic lateral sclerosis Infiltrating duct carcinoma of female breast oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm psoriasis breast cancer juvenile dermatomyositis osteosarcoma Pick disease rheumatoid arthritis herpes zoster myopathy ovarian cancer progressive supranuclear palsy
B	Pharos: Q8ND04	cataract psoriasis lung cancer medulloblastoma
C	Pharos: Q9H0W8	heart and brain malformation syndrome breast carcinoma tuberculosis estrogen-receptor negative breast cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.