6L4P

Crystal structure of the complex between the axonemal outer-arm dynein light chain-1 and microtubule binding domain of gamma heavy chain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6l4pa_	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Outer arm dynein light chain 1	Outer arm dynein light chain 1	automated matches	(Chlamydomonas reinhardtii ) [TaxId: 3055 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Outer arm dynein light chain 1	8032782	3001038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12799	e6l4pA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
B	PF12777	e6l4pB1	A: alpha bundles	X: Microtubule-Binding Domain of Flagellar Dynein (From Topology)	H: Microtubule-Binding Domain of Flagellar Dynein (From Topology)	T: Microtubule-Binding Domain of Flagellar Dynein	F: PF12777	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12799	Leucine Rich repeats (2 copies) (LRR_4)	Leucine Rich repeats (2 copies)	-	Repeat
B	PF12777	Microtubule-binding stalk of dynein motor (MT)	Microtubule-binding stalk of dynein motor	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures describ ...	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dynein light chain 1, axonemal	-	-	membrane-bounded organelle protein-containing complex outer dynein arm intracellular anatomical structure axoneme axonemal dynein complex dynein complex plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle catalytic complex membrane-bounded organelle protein-containing complex outer dynein arm intracellular anatomical structure axoneme axonemal dynein complex dynein complex plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle catalytic complex ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cell projection organelle intracellular non-membrane-bounded organelle cytoplasm motile cilium polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
B	Flagellar outer dynein arm heavy chain gamma	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding dynein light intermediate chain binding protein binding microtubule motor activity cytoskeletal motor activity minus-end-directed microtubule motor activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity dynein intermediate chain binding	cilium-dependent cell motility cellular process microtubule-based movement microtubule-based process cilium movement involved in cell motility cilium movement cell motility cilium or flagellum-dependent cell motility organelle assembly plasma membrane bounded cell projection organization axonemal dynein complex assembly protein-containing complex organization cell projection organization microtubule cytoskeleton organization cilium-dependent cell motility cellular process microtubule-based movement microtubule-based process cilium movement involved in cell motility cilium movement cell motility cilium or flagellum-dependent cell motility organelle assembly plasma membrane bounded cell projection organization axonemal dynein complex assembly protein-containing complex organization cell projection organization microtubule cytoskeleton organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis microtubule bundle formation organelle organization cellular component assembly outer dynein arm assembly protein-containing complex assembly cilium assembly cellular component organization or biogenesis axoneme assembly cytoskeleton organization cilium organization cell projection assembly	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle cell projection organelle cilium motile cilium plasma membrane bounded cell projection protein-containing complex catalytic complex dynein complex intracellular organelle cytoskeleton intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle cell projection organelle cilium motile cilium plasma membrane bounded cell projection protein-containing complex catalytic complex dynein complex intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR025875	Leucine rich repeat 4	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR001611	Leucine-rich repeat	Repeat
B	IPR026983	Dynein heavy chain	Family
B	IPR013602	Dynein heavy chain, linker	Domain
B	IPR035706	Dynein heavy chain, ATP-binding dynein motor region	Domain
B	IPR041228	Dynein heavy chain, C-terminal domain	Domain
B	IPR003593	AAA+ ATPase domain	Domain
B	IPR041466	Dynein heavy chain, AAA 5 extension domain	Domain
B	IPR041658	Dynein heavy chain AAA lid domain	Domain
B	IPR041589	Dynein heavy chain 3, AAA+ lid domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR042228	Dynein heavy chain, linker, subdomain 3	Homologous Superfamily
B	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Domain
B	IPR042219	Dynein heavy chain AAA lid domain superfamily	Homologous Superfamily
B	IPR024743	Dynein heavy chain, coiled coil stalk	Domain
B	IPR013594	Dynein heavy chain, tail	Domain
B	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain	Homologous Superfamily
B	IPR042222	Dynein heavy chain, domain 2, N-terminal	Homologous Superfamily
B	IPR043160	Dynein heavy chain, C-terminal domain, barrel region	Homologous Superfamily
B	IPR004273	Dynein heavy chain region D6 P-loop domain	Domain
B	IPR024317	Dynein heavy chain, AAA module D4	Domain