Annotations: 6KWX

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11919,PF16507	e6kwxA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Proteasome activator BLM10 (From Topology)	T: Proteasome activator BLM10	F: PF11919,PF16507	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16507	Proteasome-substrate-size regulator, mid region (BLM10_mid)	Proteasome-substrate-size regulator, mid region	-	Family
A	PF11919	Domain of unknown function (DUF3437) (DUF3437)	Domain of unknown function (DUF3437)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Proteasome activator complex subunit 4	enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity protein binding binding modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding protein-containing complex binding proteasome binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process cell development cellular process involved in reproduction in multicellular organism cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation cellular component organization protein-DNA complex organization cell differentiation chromatin organization anatomical structure development cellular component organization or biogenesis sperm DNA condensation developmental process protein-containing complex organization multicellular organismal reproductive process male gamete generation nucleus organization organelle organization germ cell development spermatid nucleus differentiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis protein metabolic process organic substance catabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex spermatoproteasome complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032430	Proteasome activator Blm10, mid region	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR021843	Proteasome activator complex subunit 4 C-terminal domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR035309	Proteasome activator complex subunit 4	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14997	HIV infectious disease progressive supranuclear palsy tuberculosis anorexia nervosa endogenous depression HIV Coinfection large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis ulcerative colitis breast cancer gastric carcinoma lung cancer HIV infectious disease progressive supranuclear palsy tuberculosis anorexia nervosa endogenous depression HIV Coinfection large cell medulloblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis ulcerative colitis breast cancer gastric carcinoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma Pick disease sarcoidosis chronic obstructive pulmonary disease glioblastoma invasive ductal breast carcinoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.