Annotations: 6KVA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	V-set_8	e6kvaH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
A [auth H]	C1-set_1	e6kvaH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C [auth h]	V-set_8	e6kvah1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth h]	C1-set_1	e6kvah2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B [auth L]	C1-set	e6kvaL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
B [auth L]	V-set_5	e6kvaL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_5	ECOD (1.6)
D [auth l]	C1-set	e6kval2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
D [auth l]	V-set_5	e6kval1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_5	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], C [auth h]	Heavy Chain	IGHV1	-	peptide from c-x-c chemokine receptor type 2	SAbDab (2024-04-19)
B [auth L], D [auth l]	Light Chain	IGLV5	Lambda	peptide from c-x-c chemokine receptor type 2	SAbDab (2024-04-19)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], C [auth h]	heavy chain	-	-	-
B [auth L], D [auth l]	light chain	-	-	-
E [auth B], F [auth b]	Peptide from C-X-C chemokine receptor type 2	G protein-coupled chemoattractant receptor activity molecular transducer activity interleukin-8 receptor activity C-X-C chemokine receptor activity chemokine receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity C-C chemokine receptor activity protein binding binding chemokine binding G protein-coupled chemoattractant receptor activity molecular transducer activity interleukin-8 receptor activity C-X-C chemokine receptor activity chemokine receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity C-C chemokine receptor activity protein binding binding chemokine binding C-X-C chemokine binding interleukin-8 binding cytokine binding C-C chemokine binding	developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development central nervous system development midbrain development anatomical structure development system development positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development central nervous system development midbrain development anatomical structure development system development positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport response to stimulus immune response immune system process defense response response to stress inflammatory response acute inflammatory response to antigenic stimulus acute inflammatory response inflammatory response to antigenic stimulus regulation of cellular process homeostatic process leukocyte apoptotic process negative regulation of biological process regulation of programmed cell death regulation of neutrophil apoptotic process negative regulation of leukocyte apoptotic process negative regulation of neutrophil apoptotic process negative regulation of cellular process regulation of immune system process myeloid cell homeostasis regulation of leukocyte apoptotic process myeloid cell apoptotic process regulation of biological process negative regulation of programmed cell death regulation of apoptotic process cell death neutrophil homeostasis neutrophil apoptotic process negative regulation of apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis inflammatory cell apoptotic process negative regulation of myeloid cell apoptotic process homeostasis of number of cells apoptotic process programmed cell death regulation of myeloid cell apoptotic process neutrophil activation cell activation myeloid leukocyte activation granulocyte activation leukocyte activation cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion positive regulation of locomotion regulation of cell motility positive regulation of chemotaxis positive regulation of cell migration positive regulation of neutrophil chemotaxis positive regulation of immune system process regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte chemotaxis positive regulation of granulocyte chemotaxis regulation of response to stimulus regulation of locomotion regulation of neutrophil chemotaxis regulation of neutrophil migration regulation of response to external stimulus positive regulation of biological process positive regulation of response to stimulus regulation of granulocyte chemotaxis positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration positive regulation of cellular process positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation dendritic cell chemotaxis dendritic cell migration mononuclear cell migration cell surface receptor signaling pathway regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of vascular permeability system process circulatory system process positive regulation of vascular permeability vascular process in circulatory system blood circulation cellular defense response epithelium development kidney epithelium development metanephric tubule morphogenesis morphogenesis of an epithelium metanephric epithelium development tissue development renal system development tissue morphogenesis metanephros development metanephric tubule development epithelial tube morphogenesis kidney development response to organic substance response to cytokine cytokine-mediated signaling pathway cellular response to interleukin-8 response to interleukin-8 cellular response to cytokine stimulus cellular response to organic substance interleukin-8-mediated signaling pathway	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle mast cell granule cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle mast cell granule organelle cytoplasm lysosome mitotic spindle cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular vesicle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle vesicle organelle membrane secretory granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth B], F [auth b]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
E [auth B], F [auth b]	IPR000057	CXC chemokine receptor 2	Family
E [auth B], F [auth b]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
E [auth B], F [auth b]	IPR000174	CXC chemokine receptor 1/2	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth B], F [auth b]	Pharos: P25025	ulcerative colitis middle cerebral artery infarction allergic disease hypertensive disorder mastitis pneumonia Sepsis malignant pancreatic neoplasm ovarian cancer psoriasis tuberculosis lung carcinoma non-small cell lung carcinoma cancer esophageal adenocarcinoma ulcerative colitis middle cerebral artery infarction allergic disease hypertensive disorder mastitis pneumonia Sepsis malignant pancreatic neoplasm ovarian cancer psoriasis tuberculosis lung carcinoma non-small cell lung carcinoma cancer esophageal adenocarcinoma hepatocellular carcinoma lung adenocarcinoma malignant colon neoplasm osteosarcoma pneumonitis cutaneous lupus erythematosus exocrine pancreatic carcinoma transitional cell carcinoma juvenile idiopathic arthritis lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.