6KU0

Crystal structure of MyoVa-GTD in complex with MICAL1-GTBM

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d6ku0c_	All alpha proteins	alpha-alpha superhelix	DIL domain-like	DIL domains from class V myosins	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d6ku0a_	All alpha proteins	alpha-alpha superhelix	DIL domain-like	DIL domains from class V myosins	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF01843	e6ku0C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01843	ECOD (1.6)
A	PF01843	e6ku0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01843	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF01843	DIL domain (DIL)	DIL domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Unconventional myosin-Va	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding identical protein binding cation binding calcium ion binding metal ion binding syntaxin-1 binding SNARE binding syntaxin binding ATP-dependent protein binding kinase binding protein kinase binding calcium-dependent protein binding disordered domain specific binding protein domain specific binding microfilament motor activity ATP-dependent activity	vesicle localization localization organelle localization secretory granule localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization vesicle localization localization organelle localization secretory granule localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane pigment metabolic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process secondary metabolite biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process monoamine transport nitrogen compound transport negative regulation of amine transport signaling regulation of catecholamine secretion negative regulation of biological process negative regulation of transport organic hydroxy compound transport dopamine transport cell communication secretion by cell regulation of secretion by cell negative regulation of secretion catecholamine transport negative regulation of dopamine secretion signal release negative regulation of cellular process negative regulation of secretion by cell secretion regulation of transport organic substance transport export from cell cell-cell signaling negative regulation of catecholamine secretion dopamine secretion regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion organonitrogen compound metabolic process dopamine metabolic process catechol-containing compound metabolic process amine metabolic process catecholamine metabolic process biogenic amine metabolic process pigmentation developmental pigmentation developmental process anatomical structure morphogenesis odontogenesis animal organ development anatomical structure development animal organ morphogenesis establishment of organelle localization establishment of melanosome localization establishment of vesicle localization cellular pigmentation pigment granule transport establishment of pigment granule localization pigment granule localization establishment of localization in cell melanosome transport melanosome localization negative regulation of signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission negative regulation of cell communication synaptic signaling trans-synaptic signaling regulation of signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication negative regulation of synaptic transmission, glutamatergic cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization actin filament-based movement establishment of protein localization hormone secretion protein localization to extracellular region peptide secretion amide transport regulation of biological quality regulation of hormone levels establishment of protein localization to extracellular region protein secretion peptide transport protein transport peptide hormone secretion hormone transport insulin secretion response to stimulus defense response response to stress reactive gliosis inflammatory response neuroinflammatory response cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly protein transport along microtubule microtubule-based protein transport transport along microtubule axo-dendritic protein transport intracellular transport axo-dendritic transport microtubule-based transport microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement intracellular protein transport inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of postsynaptic cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis pigment cell differentiation cellular developmental process cell differentiation melanocyte differentiation establishment of ER localization endoplasmic reticulum localization endoplasmic reticulum organization establishment of endoplasmic reticulum localization to postsynapse endomembrane system organization cellular response to stimulus cellular response to nitrogen compound response to organic substance response to peptide hormone regulation of cellular response to insulin stimulus positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone cellular response to organic substance positive regulation of cellular response to insulin stimulus cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin cellular response to insulin stimulus cell junction organization synapse organization regulation of vascular associated smooth muscle cell migration positive regulation of locomotion vascular associated smooth muscle cell migration regulation of cell motility regulation of smooth muscle cell migration positive regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of vascular associated smooth muscle cell migration cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy process utilizing autophagic mechanism multicellular organismal process epithelium development epidermis development molting cycle process hair cycle developmental maturation tissue development skin development anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation sensory perception of light stimulus system process sensory perception nervous system process visual perception regulation of vesicle-mediated transport exocytosis regulation of exocytosis behavior locomotory behavior locomotion involved in locomotory behavior myelination multicellular organism development axon ensheathment ensheathment of neurons nervous system development system development vesicle transport along actin filament vesicle cytoskeletal trafficking actin filament-based transport oxoacid metabolic process cellular biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process small molecule metabolic process fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process cellular lipid metabolic process monocarboxylic acid metabolic process lipid metabolic process	membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton actomyosin non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular vesicle membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton actomyosin non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle endoplasmic reticulum smooth endoplasmic reticulum somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex myosin complex synapse cell junction glutamatergic synapse non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium unconventional myosin complex Golgi apparatus endosome recycling endosome ruffle cell leading edge cell body neuronal cell body axon actomyosin, myosin complex part insulin-responsive compartment postsynapse transport vesicle presynapse synaptic vesicle exocytic vesicle postsynaptic cytoskeleton postsynaptic actin cytoskeleton pigment granule melanosome polymeric cytoskeletal fiber intermediate filament cytoskeleton intermediate filament supramolecular fiber supramolecular polymer supramolecular complex filopodium tip actin-based cell projection filopodium Schaffer collateral - CA1 synapse ribonucleoprotein complex
B, D	Peptide from [F-actin]-monooxygenase MICAL1	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding NAD(P)H oxidase H2O2-forming activity oxidoreductase activity NADPH oxidase H202-forming activity oxidoreductase activity, acting on NAD(P)H catalytic activity small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding NAD(P)H oxidase H2O2-forming activity oxidoreductase activity NADPH oxidase H202-forming activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding monooxygenase activity SH3 domain binding protein domain specific binding kinase binding protein kinase binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen cation binding metal ion binding	cellular metabolic process sulfur compound metabolic process metabolic process cellular process sulfur oxidation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process cellular metabolic process sulfur compound metabolic process metabolic process cellular process sulfur oxidation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process cellular component disassembly actin polymerization or depolymerization actin cytoskeleton organization protein-containing complex organization actin filament organization protein-containing complex disassembly actin filament depolymerization cellular component organization organelle organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of localization regulated exocytosis transport secretion regulation of transport export from cell regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport regulation of secretion regulation of regulated secretory pathway localization secretion by cell regulation of secretion by cell exocytosis regulation of exocytosis cellular response to stimulus response to stimulus signaling signal transduction cell communication cellular component biogenesis cellular component assembly actin filament bundle organization actin filament bundle assembly	midbody cellular anatomical entity polymeric cytoskeletal fiber intracellular anatomical structure intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle midbody cellular anatomical entity polymeric cytoskeletal fiber intracellular anatomical structure intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle actin cytoskeleton cytoplasm cytosol cell periphery plasma membrane membrane axon synapse hippocampal mossy fiber expansion neuron projection axon terminus plasma membrane bounded cell projection hippocampal mossy fiber presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus intercellular bridge endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane actin filament

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002710	Dilute domain	Domain
A, C	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, C	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, C	IPR036103	Class V myosin, motor domain	Domain
A, C	IPR037988	Myosin 5a, cargo-binding domain	Domain
A, C	IPR001609	Myosin head, motor domain	Domain
B, D	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
B, D	IPR001715	Calponin homology domain	Domain
B, D	IPR002938	FAD-binding domain	Domain
B, D	IPR022735	bMERB domain	Domain
B, D	IPR001781	Zinc finger, LIM-type	Domain
B, D	IPR036872	CH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: Q8TDZ2	Autosomal dominant epilepsy with auditory features Malignant neoplasm of breast oligodendroglioma pancreatic ductal adenocarcinoma Pick disease gastric carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma spina bifida malignant mesothelioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.