Annotations: 6KSW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF01773,PF07662,PF07670	e6kswC1	A: alpha complex topology	X: Concentrative nucleoside transporter (From Topology)	H: Concentrative nucleoside transporter (From Topology)	T: Concentrative nucleoside transporter	F: PF01773,PF07662,PF07670	ECOD (1.6)
B [auth A]	PF01773,PF07662,PF07670	e6kswA1	A: alpha complex topology	X: Concentrative nucleoside transporter (From Topology)	H: Concentrative nucleoside transporter (From Topology)	T: Concentrative nucleoside transporter	F: PF01773,PF07662,PF07670	ECOD (1.6)
C [auth B]	PF01773,PF07662,PF07670	e6kswB1	A: alpha complex topology	X: Concentrative nucleoside transporter (From Topology)	H: Concentrative nucleoside transporter (From Topology)	T: Concentrative nucleoside transporter	F: PF01773,PF07662,PF07670	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B]	PF07670	Nucleoside recognition (Gate)	Nucleoside recognition	This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g. Swiss:O25396), which are believed to be Fe2+ transporter ...	This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g. Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity [2]. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.	Domain
A [auth C], B [auth A], C [auth B]	PF07662	Na+ dependent nucleoside transporter C-terminus (Nucleos_tra2_C)	Na+ dependent nucleoside transporter C-terminus	-	Family
A [auth C], B [auth A], C [auth B]	PF01773	Na+ dependent nucleoside transporter N-terminus (Nucleos_tra2_N)	Na+ dependent nucleoside transporter N-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B]	Solute carrier family 28 member 3	monoatomic cation transmembrane transporter activity purine-specific nucleoside:sodium symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity purine-specific nucleoside:sodium symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity symporter activity nucleoside:sodium symporter activity carbohydrate derivative transmembrane transporter activity nucleoside transmembrane transporter activity nucleobase-containing compound transmembrane transporter activity uridine transmembrane transporter activity pyrimidine nucleoside transmembrane transporter activity nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity nucleobase:monoatomic cation symporter activity pyrimidine- and adenosine-specific:sodium symporter activity purine nucleobase transmembrane transporter activity	cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus cellular metabolic process cellular process metabolic process xenobiotic metabolic process response to xenobiotic stimulus nitrogen compound transport nucleoside transmembrane transport transport nucleoside transport cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus cellular metabolic process cellular process metabolic process xenobiotic metabolic process response to xenobiotic stimulus nitrogen compound transport nucleoside transmembrane transport transport nucleoside transport organic substance transport carbohydrate derivative transport establishment of localization transmembrane transport localization nucleobase-containing compound transport purine nucleoside transmembrane transport purine-containing compound transmembrane transport pyrimidine nucleoside transport xenobiotic transmembrane transport xenobiotic transport pyrimidine-containing compound transmembrane transport uridine transmembrane transport purine nucleobase transport nucleobase transport purine nucleobase transmembrane transport	brush border membrane membrane plasma membrane cellular anatomical entity cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell periphery cell projection plasma membrane region cell projection membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment brush border membrane membrane plasma membrane cellular anatomical entity cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell periphery cell projection plasma membrane region cell projection membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B]	IPR008276	Concentrative nucleoside transporter	Family
A [auth C], B [auth A], C [auth B]	IPR002668	Concentrative nucleoside transporter N-terminal domain	Domain
A [auth C], B [auth A], C [auth B]	IPR011657	Concentrative nucleoside transporter C-terminal domain	Domain
A [auth C], B [auth A], C [auth B]	IPR011642	Nucleoside transporter/FeoB GTPase, Gate domain	Domain
A [auth C], B [auth A], C [auth B]	IPR018270	Concentrative nucleoside transporter, metazoan/bacterial	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth A], C [auth B]	Pharos: Q9HAS3	attention deficit hyperactivity disorder, inattentive type diabetes mellitus malignant ependymoma ovarian cancer psoriasis breast cancer lung adenocarcinoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis Crohn disease malignant colon neoplasm osteosarcoma pituitary cancer

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B [auth A], C [auth B]	OPM				Concentrative nucleoside transporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth A], C [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth C], B [auth A], C [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth C], B [auth A], C [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier (SLC) Transporter Superfamily	concentrative nucleoside transporter CNT3 (SLC29 family)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.