6KMU

P22/P10 complex of caspase-11 mutant C254A

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00656	e6kmuA1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
E	PF00656	e6kmuE1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
B	PF00656	e6kmuB1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
F	PF00656	e6kmuF1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
H	PF00656	e6kmuH1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
C	PF00656	e6kmuC1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
D	PF00656	e6kmuD1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)
G	PF00656	e6kmuG1	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: PF00656	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (utative)
F	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (utative)
H	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (utative)
D	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
B, F, H	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
C	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
D	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
G	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E	Caspase-4	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding protein binding CARD domain binding protein domain specific binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to bacterium detection of chemical stimulus response to external biotic stimulus response to molecule of bacterial origin organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein autoprocessing biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process response to interleukin-18 response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus cellular response to organic substance signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway cellular response to interleukin-18 regulation of cytokine-mediated signaling pathway biological regulation interleukin-18-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus regulation of response to stimulus regulation of interleukin-18-mediated signaling pathway positive regulation of interleukin-18-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response pyroptosis cell death programmed cell death immune response defense response to symbiont immune system process defense response to other organism innate immune response regulation of apoptotic process apoptotic process regulation of programmed cell death defense response to bacterium multicellular organismal process interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly immune response-regulating signaling pathway protein-containing complex assembly cellular component organization or biogenesis positive regulation of innate immune response protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death non-canonical inflammasome complex assembly regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization defense response to Gram-positive bacterium	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane non-canonical inflammasome complex extracellular region somatodendritic compartment cell body neuronal cell body canonical inflammasome complex NLRP1 inflammasome complex
B, F, H	Caspase-4	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding protein binding CARD domain binding protein domain specific binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to bacterium detection of chemical stimulus response to external biotic stimulus response to molecule of bacterial origin organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein autoprocessing biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process response to interleukin-18 response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus cellular response to organic substance signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway cellular response to interleukin-18 regulation of cytokine-mediated signaling pathway biological regulation interleukin-18-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus regulation of response to stimulus regulation of interleukin-18-mediated signaling pathway positive regulation of interleukin-18-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response pyroptosis cell death programmed cell death immune response defense response to symbiont immune system process defense response to other organism innate immune response regulation of apoptotic process apoptotic process regulation of programmed cell death defense response to bacterium multicellular organismal process interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly immune response-regulating signaling pathway protein-containing complex assembly cellular component organization or biogenesis positive regulation of innate immune response protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death non-canonical inflammasome complex assembly regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization defense response to Gram-positive bacterium	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane non-canonical inflammasome complex extracellular region somatodendritic compartment cell body neuronal cell body canonical inflammasome complex NLRP1 inflammasome complex
C	Caspase-4	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding protein binding CARD domain binding protein domain specific binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to bacterium detection of chemical stimulus response to external biotic stimulus response to molecule of bacterial origin organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein autoprocessing biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process response to interleukin-18 response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus cellular response to organic substance signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway cellular response to interleukin-18 regulation of cytokine-mediated signaling pathway biological regulation interleukin-18-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus regulation of response to stimulus regulation of interleukin-18-mediated signaling pathway positive regulation of interleukin-18-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response pyroptosis cell death programmed cell death immune response defense response to symbiont immune system process defense response to other organism innate immune response regulation of apoptotic process apoptotic process regulation of programmed cell death defense response to bacterium multicellular organismal process interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly immune response-regulating signaling pathway protein-containing complex assembly cellular component organization or biogenesis positive regulation of innate immune response protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death non-canonical inflammasome complex assembly regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization defense response to Gram-positive bacterium	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane non-canonical inflammasome complex extracellular region somatodendritic compartment cell body neuronal cell body canonical inflammasome complex NLRP1 inflammasome complex
D	Caspase-4	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding protein binding CARD domain binding protein domain specific binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to bacterium detection of chemical stimulus response to external biotic stimulus response to molecule of bacterial origin organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein autoprocessing biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process response to interleukin-18 response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus cellular response to organic substance signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway cellular response to interleukin-18 regulation of cytokine-mediated signaling pathway biological regulation interleukin-18-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus regulation of response to stimulus regulation of interleukin-18-mediated signaling pathway positive regulation of interleukin-18-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response pyroptosis cell death programmed cell death immune response defense response to symbiont immune system process defense response to other organism innate immune response regulation of apoptotic process apoptotic process regulation of programmed cell death defense response to bacterium multicellular organismal process interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly immune response-regulating signaling pathway protein-containing complex assembly cellular component organization or biogenesis positive regulation of innate immune response protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death non-canonical inflammasome complex assembly regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization defense response to Gram-positive bacterium	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane non-canonical inflammasome complex extracellular region somatodendritic compartment cell body neuronal cell body canonical inflammasome complex NLRP1 inflammasome complex
G	Caspase-4	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process binding lipid binding lipopolysaccharide binding carbohydrate derivative binding scaffold protein binding protein binding CARD domain binding protein domain specific binding	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to organic substance biological process involved in interspecies interaction between organisms response to stimulus detection of external biotic stimulus response to lipid response to other organism detection of lipopolysaccharide response to oxygen-containing compound response to external stimulus detection of molecule of bacterial origin detection of biotic stimulus response to lipopolysaccharide response to biotic stimulus detection of stimulus response to chemical response to bacterium detection of chemical stimulus response to external biotic stimulus response to molecule of bacterial origin organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein autoprocessing biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process response to interleukin-18 response to cytokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to cytokine stimulus cellular response to organic substance signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway cellular response to interleukin-18 regulation of cytokine-mediated signaling pathway biological regulation interleukin-18-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus regulation of response to stimulus regulation of interleukin-18-mediated signaling pathway positive regulation of interleukin-18-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response pyroptosis cell death programmed cell death immune response defense response to symbiont immune system process defense response to other organism innate immune response regulation of apoptotic process apoptotic process regulation of programmed cell death defense response to bacterium multicellular organismal process interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly immune response-regulating signaling pathway protein-containing complex assembly cellular component organization or biogenesis positive regulation of innate immune response protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death non-canonical inflammasome complex assembly regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization defense response to Gram-positive bacterium	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane protein-containing complex organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane non-canonical inflammasome complex extracellular region somatodendritic compartment cell body neuronal cell body canonical inflammasome complex NLRP1 inflammasome complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E	IPR001309	Peptidase C14, p20 domain	Domain
A, E	IPR011600	Peptidase C14, caspase domain	Domain
A, E	IPR016129	Peptidase family C14A, His active site	Active Site
A, E	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
A, E	IPR011029	Death-like domain superfamily	Homologous Superfamily
A, E	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
A, E	IPR033139	Peptidase family C14A, cysteine active site	Active Site
A, E	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
A, E	IPR001315	CARD domain	Domain
B, F, H	IPR001309	Peptidase C14, p20 domain	Domain
B, F, H	IPR011600	Peptidase C14, caspase domain	Domain
B, F, H	IPR016129	Peptidase family C14A, His active site	Active Site
B, F, H	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
B, F, H	IPR011029	Death-like domain superfamily	Homologous Superfamily
B, F, H	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
B, F, H	IPR033139	Peptidase family C14A, cysteine active site	Active Site
B, F, H	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
B, F, H	IPR001315	CARD domain	Domain
C	IPR001309	Peptidase C14, p20 domain	Domain
C	IPR011600	Peptidase C14, caspase domain	Domain
C	IPR016129	Peptidase family C14A, His active site	Active Site
C	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
C	IPR011029	Death-like domain superfamily	Homologous Superfamily
C	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
C	IPR033139	Peptidase family C14A, cysteine active site	Active Site
C	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
C	IPR001315	CARD domain	Domain
D	IPR001309	Peptidase C14, p20 domain	Domain
D	IPR011600	Peptidase C14, caspase domain	Domain
D	IPR016129	Peptidase family C14A, His active site	Active Site
D	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
D	IPR011029	Death-like domain superfamily	Homologous Superfamily
D	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
D	IPR033139	Peptidase family C14A, cysteine active site	Active Site
D	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
D	IPR001315	CARD domain	Domain
G	IPR001309	Peptidase C14, p20 domain	Domain
G	IPR011600	Peptidase C14, caspase domain	Domain
G	IPR016129	Peptidase family C14A, His active site	Active Site
G	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
G	IPR011029	Death-like domain superfamily	Homologous Superfamily
G	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
G	IPR033139	Peptidase family C14A, cysteine active site	Active Site
G	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
G	IPR001315	CARD domain	Domain