Annotations: 6KLR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21032	e6klrA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF21032	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21032	PROPPIN (PROPPIN)	PROPPIN	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	chimera ATG2A and WIPI3	binding phospholipid binding lipid binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding lipid transporter activity lipid transfer activity transporter activity phosphatidylinositol-3,5-bisphosphate binding ion binding anion binding phosphatidylinositol bisphosphate binding small molecule binding binding phospholipid binding lipid binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding lipid transporter activity lipid transfer activity transporter activity phosphatidylinositol-3,5-bisphosphate binding ion binding anion binding phosphatidylinositol bisphosphate binding small molecule binding protein-containing complex binding TSC1-TSC2 complex binding	autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly cellular process autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly cellular process metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism piecemeal microautophagy of the nucleus microautophagy nucleophagy positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of vacuole organization positive regulation of biological process positive regulation of cellular metabolic process regulation of autophagy positive regulation of metabolic process positive regulation of autophagosome assembly positive regulation of macroautophagy positive regulation of cellular process positive regulation of autophagy regulation of biological process positive regulation of cellular component biogenesis biological regulation regulation of autophagosome assembly regulation of cellular metabolic process regulation of catabolic process regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle organization positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process regulation of organelle assembly positive regulation of cellular catabolic process regulation of metabolic process positive regulation of organelle assembly cellular component disassembly organelle disassembly reticulophagy cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to starvation protein localization cellular localization localization cellular macromolecule localization macromolecule localization protein localization to phagophore assembly site	lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle phagophore assembly site membrane membrane phagophore assembly site cytoplasm organelle membrane contact site membrane-bounded organelle organelle subcompartment lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle phagophore assembly site membrane membrane phagophore assembly site cytoplasm organelle membrane contact site membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cytosol extrinsic component of membrane lytic vacuole vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR015412	Atg2/VPS13, C-terminal	Domain
A, B	IPR026849	Autophagy-related protein 2	Family
A, B	IPR026854	Vacuolar protein sorting-associated protein 13-like, N-terminal domain	Domain
A, B	IPR048720	PROPPIN	Family
A, B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR001680	WD40 repeat	Repeat
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q5MNZ6	astrocytic tumor gout osteosarcoma intellectual disability epilepsy Mental deficiency ovarian cancer psoriasis plasma cell myeloma neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.