6KLE

Monomeric structure of Machupo virus polymerase bound to vRNA promoter

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17296	Arenavirus cap snatching domain (ArenaCapSnatch)	Arenavirus cap snatching domain	This domain represents the N-terminal domain of the Arenavirus polymerase that is involved in cap snatching during transcription initiation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RNA-directed RNA polymerase L	5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups hydrolase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups hydrolase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	viral gene expression cap snatching negative stranded viral RNA transcription viral process viral transcription RNA-templated viral transcription cellular biosynthetic process RNA metabolic process viral life cycle RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral RNA genome replication viral gene expression cap snatching negative stranded viral RNA transcription viral process viral transcription RNA-templated viral transcription cellular biosynthetic process RNA metabolic process viral life cycle RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process viral RNA genome replication organic substance biosynthetic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process negative stranded viral RNA replication viral genome replication biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process	virion component host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity
B	RNA (5'-R(GPCPCPUPAPGPGPAPUPCPCPAPCPUPGPUPGPCP*G)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007099	RNA-directed RNA polymerase, negative-strand RNA virus	Domain
A	IPR026382	RNA endonuclease, cap-snatching, arenaviral	Domain
A	IPR048006	RNA endonuclease, cap-snatching, bunyaviral	Domain
A	IPR010453	RNA polymerase, arenaviral	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.