6KHZ

p62/SQSTM1 ZZ domain with Gly-peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RING/U-box like	8081306	3000160	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RING/U-box like	8081306	3000160	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RING/U-box like	8081306	3000160	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RING/U-box like	8081306	3000160	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00569	e6khzA1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF00569	ECOD (1.6)
B	PF00569	e6khzB1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF00569	ECOD (1.6)
C	PF00569	e6khzC1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF00569	ECOD (1.6)
D	PF00569	e6khzD1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF00569	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00569	Zinc finger, ZZ type (ZZ)	Zinc finger, ZZ type	Zinc finger present in dystrophin, CBP/p300. ZZ in dystrophin binds calmodulin. Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Sequestosome-1	protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding binding molecular sequestering activity protein tyrosine kinase binding protein binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding binding molecular sequestering activity protein tyrosine kinase binding protein binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding molecular transducer activity signaling receptor activity signaling adaptor activity SH2 domain binding protein domain specific binding molecular condensate scaffold activity ubiquitin binding ubiquitin-like protein binding ionotropic glutamate receptor binding glutamate receptor binding polyubiquitin modification-dependent protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding protein sequestering activity ubiquitin-modified protein reader activity ubiquitin-like protein reader activity protein kinase C binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway negative regulation of biological process regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway negative regulation of biological process regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway regulation of biological process immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of toll-like receptor 4 signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of signaling signaling positive regulation of biological process innate immune response activating cell surface receptor signaling pathway negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress negative regulation of cellular process innate immune response response to external biotic stimulus negative regulation of toll-like receptor 4 signaling pathway cell surface pattern recognition receptor signaling pathway regulation of signaling positive regulation of innate immune response cell surface receptor signaling pathway negative regulation of response to stimulus defense response biological regulation defense response to symbiont negative regulation of signal transduction negative regulation of immune system process immune system process toll-like receptor 4 signaling pathway regulation of cell communication cellular process protein localization localization cellular localization cellular macromolecule localization macromolecule localization negative regulation of post-translational protein modification regulation of protein modification process regulation of protein ubiquitination regulation of primary metabolic process organic substance metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of protein localization to plasma membrane regulation of localization regulation of protein localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to plasma membrane response to ischemia cellular catabolic process catabolic process cellular metabolic process autophagy process utilizing autophagic mechanism regulation of protein complex stability regulation of biological quality macroautophagy aggrephagy apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process organonitrogen compound catabolic process protein catabolic process macromolecule catabolic process organic substance catabolic process cellular response to stress response to mitochondrial depolarisation small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction Ras protein signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of Ras protein signal transduction intracellular signaling cassette establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process fat cell proliferation cell population proliferation brown fat cell proliferation vesicle-mediated transport endosomal transport regulation of cellular component organization regulation of organelle organization cellular component organization organelle organization regulation of mitochondrion organization cellular component organization or biogenesis mitochondrion organization negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process positive regulation of autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process vesicle organization endosome organization endomembrane system organization developmental process cellular developmental process cell differentiation positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation synaptic signaling positive regulation of long-term synaptic potentiation regulation of synaptic plasticity trans-synaptic signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation positive regulation of signaling cellular component biogenesis cellular component assembly organelle assembly non-membrane-bounded organelle assembly multicellular organismal process multicellular organismal-level homeostasis homeostatic process energy homeostasis protein targeting to vacuole involved in autophagy protein targeting establishment of protein localization to vacuole protein targeting to vacuole protein localization to vacuole vacuolar transport autophagy of peroxisome pexophagy cellular component disassembly organelle disassembly autophagy of mitochondrion temperature homeostasis positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of phosphorus metabolic process regulation of phosphorylation mitophagy canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction protein localization to perinuclear region of cytoplasm	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection inclusion body vacuole autophagosome intracellular membrane-bounded organelle sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex amphisome autolysosome lytic vacuole secondary lysosome lysosome phagophore assembly site mitochondrion aggresome nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Lewy body endosome intracellular vesicle endomembrane system cytoplasmic vesicle late endosome cytoplasmic ribonucleoprotein granule ribonucleoprotein granule P-body endoplasmic reticulum nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A, B, C, D	IPR000433	Zinc finger, ZZ-type	Domain
A, B, C, D	IPR033741	Sequestosome-1, UBA domain	Domain
A, B, C, D	IPR009060	UBA-like superfamily	Homologous Superfamily
A, B, C, D	IPR000270	PB1 domain	Domain
A, B, C, D	IPR015940	Ubiquitin-associated domain	Domain
A, B, C, D	IPR034866	Sequestosome-1, PB1 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q13501	amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 3 neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset bone Paget disease Paget disease of bone 3 age-related macular degeneration neurodegenerative disease behavioral variant of frontotemporal dementia NONAKA MYOPATHY Paget disease of bone 2, early-onset pancreatic intraductal papillary-mucinous carcinoma sarcoma tuberculosis GNE myopathy large cell medulloblastoma amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 3 neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset bone Paget disease Paget disease of bone 3 age-related macular degeneration neurodegenerative disease behavioral variant of frontotemporal dementia NONAKA MYOPATHY Paget disease of bone 2, early-onset pancreatic intraductal papillary-mucinous carcinoma sarcoma tuberculosis GNE myopathy large cell medulloblastoma medulloblastoma osteosarcoma pituitary cancer Alzheimer disease spina bifida cancer hepatocellular carcinoma lung cancer myopathy, distal, with rimmed vacuoles non-small cell lung carcinoma ovarian cancer pancreatic ductal adenocarcinoma psoriasis subependymal giant cell astrocytoma distal myopathy frontotemporal dementia with motor neuron disease malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.