Annotations: 6KHX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6khxa1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
A	d6khxa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
B	d6khxb1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
B	d6khxb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
C	d6khxc1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
C	d6khxc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
D	d6khxd1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
D	d6khxd2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
E	d6khxe1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
E	d6khxe2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
F	d6khxf1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
F	d6khxf2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
G	d6khxg1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
G	d6khxg2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
H	d6khxh1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
H	d6khxh2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
I	d6khxi1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
I	d6khxi2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
J	d6khxj1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)
J	d6khxj2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Akkermansia muciniphila ) [TaxId: 239935 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00578,PF10417	e6khxA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
B	PF00578,PF10417	e6khxB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
C	PF00578,PF10417	e6khxC1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
D	PF00578,PF10417	e6khxD1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
E	PF00578,PF10417	e6khxE1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
F	PF00578,PF10417	e6khxF1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
G	PF00578,PF10417	e6khxG1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
H	PF00578,PF10417	e6khxH1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
I	PF00578,PF10417	e6khxI1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)
J	PF00578,PF10417	e6khxJ1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578,PF10417	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
B	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
C	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
D	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
E	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
F	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
G	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
H	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
I	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)
J	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00578	AhpC/TSA family (AhpC-TSA)	AhpC/TSA family	This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF10417	C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx_C)	C-terminal domain of 1-Cys peroxiredoxin	This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding al ...	This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [1]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme [2]. The domain is associated with family AhpC-TSA, Pfam:PF00578, which carries the catalytic cysteine.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Peroxiredoxin	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity peroxiredoxin activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR019479	Peroxiredoxin, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR024706	Peroxiredoxin, AhpC-type	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR013766	Thioredoxin domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000866	Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant	Domain