Annotations: 6KDV

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	CRISPR associated protein Cas1	8099529	4006578	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	CRISPR associated protein Cas1	8099530	3002164	SCOP2 (2022-06-29)
B [auth A]	SCOP2B Superfamily	CRISPR associated protein Cas1	8099530	3002164	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	CRISPR associated protein Cas1	8099530	3002164	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	CRISPR associated protein Cas1	8099530	3002164	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF01867	e6kdvB1	A: alpha complex topology	X: Cas1 (From Topology)	H: Cas1 (From Topology)	T: Cas1	F: PF01867	ECOD (1.6)
B [auth A]	PF01867	e6kdvA1	A: alpha complex topology	X: Cas1 (From Topology)	H: Cas1 (From Topology)	T: Cas1	F: PF01867	ECOD (1.6)
C [auth D]	PF01867	e6kdvD1	A: alpha complex topology	X: Cas1 (From Topology)	H: Cas1 (From Topology)	T: Cas1	F: PF01867	ECOD (1.6)
D [auth C]	PF01867	e6kdvC1	A: alpha complex topology	X: Cas1 (From Topology)	H: Cas1 (From Topology)	T: Cas1	F: PF01867	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	1.20.120.920	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	CRISPR-associated endonuclease Cas1, C-terminal domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C [auth D], D [auth C]	PF01867	CRISPR associated protein Cas1 (Cas_Cas1)	CRISPR associated protein Cas1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C [auth D], D [auth C]	CRISPR-associated endonuclease Cas1 2	DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity DNA binding binding organic cyclic compound binding nucleic acid binding cation binding DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity DNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus maintenance of CRISPR repeat elements chromosome organization primary metabolic process DNA metabolic process maintenance of DNA repeat elements nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process	-
F, H	DNA (5'-D(TPTPTPTPTPTPTPTPTPTPCPCPAPGPCPAPTPCPGPAPCPTP*C)-3')	-	-	-
E, G	DNA (5'-D(GPAPGPTPCPGPAPTPGPCPTPGPGPTPTPTPTPTPTPTPTPTP*T)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C [auth D], D [auth C]	IPR019851	CRISPR-associated protein Cas1, ECOLI subtype	Family
A [auth B], B [auth A], C [auth D], D [auth C]	IPR002729	CRISPR-associated protein Cas1	Family
A [auth B], B [auth A], C [auth D], D [auth C]	IPR033641	CRISPR-associated protein Cas1, type I-E	Family
A [auth B], B [auth A], C [auth D], D [auth C]	IPR042206	CRISPR-associated endonuclease Cas1, C-terminal domain	Homologous Superfamily
A [auth B], B [auth A], C [auth D], D [auth C]	IPR042211	CRISPR-associated endonuclease Cas1, N-terminal domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.