6KCR

X-ray structure of the MtlR-HPr complex from Escherichia coli

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	HPr-like	8035735	3000259	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HPr-like	8035735	3000259	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF05068	e6kcrC1	A: alpha bundles	X: MtlR-like (From Topology)	H: MtlR-like (From Topology)	T: MtlR-like	F: PF05068	ECOD (1.6)
A	PF05068	e6kcrA1	A: alpha bundles	X: MtlR-like (From Topology)	H: MtlR-like (From Topology)	T: MtlR-like	F: PF05068	ECOD (1.6)
B	PF00381	e6kcrB1	A: a+b two layers	X: HPr-like (From Topology)	H: HPr-like (From Topology)	T: HPr-like	F: PF00381	ECOD (1.6)
D	PF00381	e6kcrD1	A: a+b two layers	X: HPr-like (From Topology)	H: HPr-like (From Topology)	T: HPr-like	F: PF00381	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.120.330	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Nucleotidyltransferases domain 2	CATH (utative)
A	1.20.120.330	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Nucleotidyltransferases domain 2	CATH (utative)
B	3.30.1340.10	Alpha Beta	2-Layer Sandwich	Histidine-containing Protein	Chain: A	CATH (utative)
D	3.30.1340.10	Alpha Beta	2-Layer Sandwich	Histidine-containing Protein	Chain: A	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF05068	Mannitol repressor (MtlR)	Mannitol repressor	-	Family
B, D	PF00381	PTS HPr component phosphorylation site (PTS-HPr)	PTS HPr component phosphorylation site	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Mannitol operon repressor	-	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process	-
B, D	Phosphocarrier protein HPr	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein binding binding antisigma factor binding molecular function inhibitor activity enzyme inhibitor activity transferase activity phosphotransferase activity, nitrogenous group as acceptor catalytic activity transferase activity, transferring phosphorus-containing groups	response to nutrient levels carbon utilization regulation of response to nutrient levels regulation of biological process response to stimulus regulation of response to stimulus regulation of carbon utilization biological regulation import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane response to nutrient levels carbon utilization regulation of response to nutrient levels regulation of biological process response to stimulus regulation of response to stimulus regulation of carbon utilization biological regulation import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization cellular process carbohydrate transmembrane transport regulation of cellular process carbohydrate catabolic process regulation of generation of precursor metabolites and energy regulation of primary metabolic process cellular catabolic process positive regulation of glycogen metabolic process positive regulation of metabolic process regulation of small molecule metabolic process regulation of glycogen catabolic process glycogen catabolic process small molecule metabolic process positive regulation of macromolecule metabolic process positive regulation of glycogen catabolic process regulation of carbohydrate catabolic process cellular metabolic process primary metabolic process hexose metabolic process regulation of cellular metabolic process positive regulation of glucose metabolic process polysaccharide catabolic process metabolic process energy reserve metabolic process positive regulation of carbohydrate metabolic process macromolecule metabolic process regulation of glycogen metabolic process regulation of metabolic process monosaccharide metabolic process catabolic process energy derivation by oxidation of organic compounds positive regulation of biological process positive regulation of cellular metabolic process regulation of polysaccharide metabolic process macromolecule catabolic process organic substance metabolic process glucan metabolic process polysaccharide metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of cellular process carbohydrate metabolic process glucan catabolic process glycogen metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process regulation of catabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process organic substance catabolic process glucose metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR007761	Mannitol repressor MtlR-like	Family
A, C	IPR038026	MtlR-like superfamily	Homologous Superfamily
B, D	IPR002114	Phosphotransferase system, HPr serine phosphorylation site	PTM
B, D	IPR001020	Phosphotransferase system, HPr histidine phosphorylation site	PTM
B, D	IPR000032	Phosphocarrier protein HPr-like	Domain
B, D	IPR035895	HPr-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.