Annotations: 6KBN

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00514	e6kbnA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)
C	PF00514	e6kbnC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Vacuolar protein 8	protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein binding binding	cellular component biogenesis cellular component organization organelle localization by membrane tethering localization cellular component assembly organelle localization cellular process cellular component organization or biogenesis membrane docking nucleus-vacuole junction assembly protein localization establishment of protein localization cellular localization nitrogen compound transport cellular component biogenesis cellular component organization organelle localization by membrane tethering localization cellular component assembly organelle localization cellular process cellular component organization or biogenesis membrane docking nucleus-vacuole junction assembly protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting establishment of protein localization to vacuole cytoplasm to vacuole targeting by the Cvt pathway vesicle organization cellular macromolecule localization establishment of localization in cell process utilizing autophagic mechanism protein targeting to vacuole organelle assembly organic substance transport protein localization to vacuole intracellular transport establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle vacuolar transport Cvt vesicle assembly intracellular protein transport autophagosome assembly catabolic process vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular catabolic process metabolic process piecemeal microautophagy of the nucleus microautophagy nucleophagy organic substance metabolic process primary metabolic process lipid metabolic process autophagy of peroxisome pexophagy organelle fusion vacuole fusion vacuole fusion, non-autophagic ribophagy organelle inheritance vacuole inheritance protein localization to membrane raft localization within membrane protein localization to membrane	membrane cellular anatomical entity nucleus-vacuole junction organelle membrane contact site organelle intracellular anatomical structure cytoplasm cytosol membrane microdomain membrane raft vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole membrane cellular anatomical entity nucleus-vacuole junction organelle membrane contact site organelle intracellular anatomical structure cytoplasm cytosol membrane microdomain membrane raft vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane nuclear outer membrane nuclear membrane nucleus organelle outer membrane endomembrane system organelle envelope nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane Myo2p-Vac17p-Vac8p transport complex protein-containing complex phagophore assembly site
B, D	Autophagy-related protein 13	binding lipid binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity	cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism cellular component disassembly cellular component organization organelle organization organelle disassembly cellular component organization or biogenesis autophagy of mitochondrion cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism cellular component disassembly cellular component organization organelle organization organelle disassembly cellular component organization or biogenesis autophagy of mitochondrion mitochondrion organization protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting establishment of protein localization to vacuole cytoplasm to vacuole targeting by the Cvt pathway cellular component biogenesis vesicle organization localization cellular component assembly cellular macromolecule localization establishment of localization in cell protein targeting to vacuole organelle assembly organic substance transport protein localization to vacuole intracellular transport establishment of localization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle vacuolar transport Cvt vesicle assembly intracellular protein transport autophagosome assembly vacuole organization autophagosome organization piecemeal microautophagy of the nucleus microautophagy nucleophagy regulation of localization regulation of biological process regulation of cellular process regulation of cellular localization biological regulation protein targeting to vacuole involved in autophagy mitophagy positive regulation of autophagy positive regulation of biological process regulation of cellular metabolic process positive regulation of cellular metabolic process regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of metabolic process positive regulation of cellular process protein localization to phagophore assembly site response to nutrient levels response to stimulus response to stress response to starvation	organelle membrane contact site organelle vacuole-isolation membrane contact site cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex intracellular anatomical structure catalytic complex serine/threonine protein kinase complex Atg1/ULK1 kinase complex cytoplasm transferase complex cytosol organelle membrane contact site organelle vacuole-isolation membrane contact site cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex intracellular anatomical structure catalytic complex serine/threonine protein kinase complex Atg1/ULK1 kinase complex cytoplasm transferase complex cytosol vacuolar membrane membrane-bounded organelle membrane PAS complex membrane protein complex vacuole intracellular membrane-bounded organelle phosphatidylinositol 3-kinase complex intracellular organelle bounding membrane of organelle phosphatidylinositol 3-kinase complex, class III extrinsic component of membrane organelle membrane phagophore assembly site

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR016024	Armadillo-type fold	Homologous Superfamily
A, C	IPR000225	Armadillo	Repeat
A, C	IPR011989	Armadillo-like helical	Homologous Superfamily
A, C	IPR045156	Vacuolar protein 8	Family
B, D	IPR036570	HORMA domain superfamily	Homologous Superfamily
B, D	IPR040182	Autophagy-related protein 13	Family
B, D	IPR018731	Autophagy-related protein 13, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.