Annotations: 6K8C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08245	e6k8cA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF08245	ECOD (1.6)
A	PF02875	e6k8cA2	A: a/b three-layered sandwiches	X: MurD-like peptide ligases, peptide-binding domain (From Topology)	H: MurD-like peptide ligases, peptide-binding domain (From Topology)	T: MurD-like peptide ligases, peptide-binding domain	F: PF02875	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08245	Mur ligase middle domain (Mur_ligase_M)	Mur ligase middle domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Folylpolyglutamate synthase (FolC)	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acid-amino acid ligase activity catalytic activity dihydrofolate synthase activity ligase activity, forming carbon-nitrogen bonds ligase activity tetrahydrofolylpolyglutamate synthase activity cation binding metal ion binding	folic acid-containing compound biosynthetic process organonitrogen compound metabolic process cellular metabolic process organonitrogen compound biosynthetic process cellular modified amino acid metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process cellular modified amino acid biosynthetic process organic cyclic compound biosynthetic process folic acid-containing compound metabolic process pteridine-containing compound biosynthetic process organic substance biosynthetic process metabolic process folic acid-containing compound biosynthetic process organonitrogen compound metabolic process cellular metabolic process organonitrogen compound biosynthetic process cellular modified amino acid metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process cellular modified amino acid biosynthetic process organic cyclic compound biosynthetic process folic acid-containing compound metabolic process pteridine-containing compound biosynthetic process organic substance biosynthetic process metabolic process cellular process pteridine-containing compound metabolic process tetrahydrofolate biosynthetic process tetrahydrofolate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036615	Mur ligase, C-terminal domain superfamily	Homologous Superfamily
A	IPR013221	Mur ligase, central	Domain
A	IPR001645	Folylpolyglutamate synthetase	Family
A	IPR036565	Mur-like, catalytic domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.