Annotations: 6K2F

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6k2fa1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	(Entamoeba histolytica HM-1:IMSS ) [TaxId: 294381 ],	SCOPe (2.08)
A	d6k2fa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Entamoeba histolytica HM-1:IMSS ) [TaxId: 294381 ],	SCOPe (2.08)
B	d6k2fb1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	(Entamoeba histolytica HM-1:IMSS ) [TaxId: 294381 ],	SCOPe (2.08)
B	d6k2fb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Entamoeba histolytica HM-1:IMSS ) [TaxId: 294381 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Actin depolymerizing proteins	8098082	3000430	SCOP2B (2022-06-29)
B	SCOP2 Family	Cofilin-like	8098081	4001833	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Actin depolymerizing proteins	8098082	3000430	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00241	e6k2fA1	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00241	ECOD (1.6)
B	PF00241	e6k2fB1	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00241	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00241	Cofilin/tropomyosin-type actin-binding protein (Cofilin_ADF)	Cofilin/tropomyosin-type actin-binding protein	Severs actin filaments and binds to actin monomers.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Actin binding protein family protein	cytoskeletal protein binding actin binding protein binding binding	regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size negative regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly actin filament-based process negative regulation of cellular process negative regulation of protein polymerization regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size negative regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly actin filament-based process negative regulation of cellular process negative regulation of protein polymerization regulation of actin filament polymerization cellular component organization or biogenesis regulation of biological quality negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of biological process regulation of actin filament organization actin filament polymerization actin cytoskeleton organization negative regulation of cellular component organization protein-containing complex organization negative regulation of cytoskeleton organization biological regulation actin filament organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization cytoskeleton organization regulation of anatomical structure size	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily
A, B	IPR002108	Actin-depolymerising factor homology domain	Domain
A, B	IPR028458	Twinfilin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.