6JSI

Co-purified Fatty Acid Synthase

External Resource: Annotation


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
D [auth F],
G		PF16073Starter unit:ACP transacylase in aflatoxin biosynthesis (SAT)Starter unit:ACP transacylase in aflatoxin biosynthesis- Family
A [auth B],
D [auth F],
G		PF17828N-terminal domain in fatty acid synthase subunit beta (FAS_N)N-terminal domain in fatty acid synthase subunit betaThis entry represents the N-terminal domain found in fatty acid synthase proteins such as Swiss:P07149.Domain
A [auth B],
D [auth F],
G		PF13452N-terminal half of MaoC dehydratase (MaoC_dehydrat_N)N-terminal half of MaoC dehydrataseIt is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher euka ...It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.
Domain
A [auth B],
D [auth F],
G		PF17951Fatty acid synthase meander beta sheet domain (FAS_meander)Fatty acid synthase meander beta sheet domainThis domain is found in fungal fatty acid synthase beta chain proteins [3].Domain
A [auth B],
D [auth F],
G		PF01575MaoC like domain (MaoC_dehydratas)MaoC like domainThe maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydroge ...The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1]. The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.
Domain
A [auth B],
D [auth F],
G		PF00698Acyl transferase domain (Acyl_transf_1)Acyl transferase domain- Domain
B [auth A],
E [auth D],
H [auth E]		PF00109Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)Beta-ketoacyl synthase, N-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].
Domain
B [auth A],
E [auth D],
H [auth E]		PF18314Fatty acid synthase type I helical domain (FAS_I_H)Fatty acid synthase type I helical domainThis domain is found in the fatty acid synthase (FAS) complex present in species such as Mycobacterium smegmatis and Thermomyces lanuginosus. FAS is a homo-hexameric enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids. This doma ...This domain is found in the fatty acid synthase (FAS) complex present in species such as Mycobacterium smegmatis and Thermomyces lanuginosus. FAS is a homo-hexameric enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids. This domain is composed of dimerization module 1 (DM1) and four-helix bundle (4HB), both of which are conserved parts of the acetyl transferase [1].
Domain
C,
F [auth H],
I		PF02801Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)Beta-ketoacyl synthase, C-terminal domainThe structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
D [auth F],
G		Fatty acid synthase subunit beta
B [auth A],
E [auth D],
H [auth E]		Fatty acid synthase subunit alpha
C,
F [auth H],
I		Fatty acid synthase subunit alpha

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
D [auth F],
G		IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
A [auth B],
D [auth F],
G		IPR003965Fatty acid synthaseDomain
A [auth B],
D [auth F],
G		IPR013785Aldolase-type TIM barrelHomologous Superfamily
A [auth B],
D [auth F],
G		IPR014043Acyl transferaseDomain
A [auth B],
D [auth F],
G		IPR040883Fatty acid synthase, meander beta sheet domainDomain
A [auth B],
D [auth F],
G		IPR032088Starter unit:ACP transacylaseDomain
A [auth B],
D [auth F],
G		IPR041099Fatty acid synthase subunit beta, N-terminal domainDomain
A [auth B],
D [auth F],
G		IPR039569N-terminal of MaoC-like dehydrataseDomain
A [auth B],
D [auth F],
G		IPR029069HotDog domain superfamilyHomologous Superfamily
A [auth B],
D [auth F],
G		IPR002539MaoC-like dehydratase domainDomain
A [auth B],
D [auth F],
G		IPR001227Acyl transferase domain superfamilyHomologous Superfamily
A [auth B],
D [auth F],
G		IPR013565Fatty acid synthase beta subunit AflB /Fas1-like, central domainDomain
A [auth B],
D [auth F],
G		IPR016452Fatty acid synthase beta subunit AflB /Fas1-like, fungiFamily
B [auth A],
E [auth D],
H [auth E]		IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
B [auth A],
E [auth D],
H [auth E]		IPR014031Beta-ketoacyl synthase, C-terminalDomain
B [auth A],
E [auth D],
H [auth E]		IPR002582Holo-[acyl carrier protein] synthaseFamily
B [auth A],
E [auth D],
H [auth E]		IPR040899Fatty acid synthase subunit alpha, acyl carrier domainDomain
B [auth A],
E [auth D],
H [auth E]		IPR014030Beta-ketoacyl synthase, N-terminalDomain
B [auth A],
E [auth D],
H [auth E]		IPR0371434'-phosphopantetheinyl transferase domain superfamilyHomologous Superfamily
B [auth A],
E [auth D],
H [auth E]		IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
B [auth A],
E [auth D],
H [auth E]		IPR009081Phosphopantetheine binding ACP domainDomain
B [auth A],
E [auth D],
H [auth E]		IPR041550Fatty acid synthase type I, helicalDomain
B [auth A],
E [auth D],
H [auth E]		IPR026025Fatty acid synthase alpha subunit, yeastFamily
B [auth A],
E [auth D],
H [auth E]		IPR0082784'-phosphopantetheinyl transferase domainDomain
B [auth A],
E [auth D],
H [auth E]		IPR016039Thiolase-likeHomologous Superfamily
B [auth A],
E [auth D],
H [auth E]		IPR047224Fatty acid synthase subunit alpha-like, C-terminalDomain
B [auth A],
E [auth D],
H [auth E]		IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
B [auth A],
E [auth D],
H [auth E]		IPR018201Beta-ketoacyl synthase, active siteActive Site
B [auth A],
E [auth D],
H [auth E]		IPR004568Phosphopantetheine-protein transferase domainDomain
C,
F [auth H],
I		IPR016035Acyl transferase/acyl hydrolase/lysophospholipaseHomologous Superfamily
C,
F [auth H],
I		IPR014031Beta-ketoacyl synthase, C-terminalDomain
C,
F [auth H],
I		IPR002582Holo-[acyl carrier protein] synthaseFamily
C,
F [auth H],
I		IPR040899Fatty acid synthase subunit alpha, acyl carrier domainDomain
C,
F [auth H],
I		IPR014030Beta-ketoacyl synthase, N-terminalDomain
C,
F [auth H],
I		IPR0371434'-phosphopantetheinyl transferase domain superfamilyHomologous Superfamily
C,
F [auth H],
I		IPR020841Polyketide synthase, beta-ketoacyl synthase domainDomain
C,
F [auth H],
I		IPR009081Phosphopantetheine binding ACP domainDomain
C,
F [auth H],
I		IPR041550Fatty acid synthase type I, helicalDomain
C,
F [auth H],
I		IPR026025Fatty acid synthase alpha subunit, yeastFamily
C,
F [auth H],
I		IPR0082784'-phosphopantetheinyl transferase domainDomain
C,
F [auth H],
I		IPR016039Thiolase-likeHomologous Superfamily
C,
F [auth H],
I		IPR047224Fatty acid synthase subunit alpha-like, C-terminalDomain
C,
F [auth H],
I		IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
C,
F [auth H],
I		IPR018201Beta-ketoacyl synthase, active siteActive Site
C,
F [auth H],
I		IPR004568Phosphopantetheine-protein transferase domainDomain