Annotations: 6JPP

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Engulfment and cell motility protein 1	SH3 domain binding protein binding binding protein domain specific binding	cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling Rac protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction membrane organization cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling Rac protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination apoptotic process cell death programmed cell death cell motility organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane protein-containing complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR006816	ELMO domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR024574	ELMO, armadillo-like helical domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92556	Stevens-Johnson syndrome esophageal adenocarcinoma primary biliary cholangitis psoriasis Nodular glomerulosclerosis pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma toxic epidermal necrolysis Alzheimer disease celiac disease Hashimoto thyroiditis lung adenocarcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma Stevens-Johnson syndrome esophageal adenocarcinoma primary biliary cholangitis psoriasis Nodular glomerulosclerosis pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma toxic epidermal necrolysis Alzheimer disease celiac disease Hashimoto thyroiditis lung adenocarcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis attention deficit hyperactivity disorder, inattentive type diabetic kidney disease interstitial cystitis lung cancer malignant glioma ovarian cancer Pick disease subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma lung carcinoma malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.