Annotations: 6JJZ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00397	e6jjzA1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
B	PF00397	e6jjzB1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain
C, D	PF15498	Nephrin and CD2AP-binding protein, Dendrin (Dendrin)	Nephrin and CD2AP-binding protein, Dendrin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization protein-containing complex binding binding phosphatase binding protein binding enzyme binding cytoskeletal protein binding kinesin binding activin receptor binding receptor serine/threonine kinase binding structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization protein-containing complex binding binding phosphatase binding protein binding enzyme binding cytoskeletal protein binding kinesin binding activin receptor binding receptor serine/threonine kinase binding signaling receptor binding transmembrane receptor protein serine/threonine kinase binding SMAD binding adrenergic receptor binding G protein-coupled receptor binding beta-1 adrenergic receptor binding type II activin receptor binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	positive regulation of phosphoprotein phosphatase activity protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of phosphoprotein phosphatase activity protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process regulation of biological process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation cellular metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process regulation of phosphoprotein phosphatase activity positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process positive regulation of cellular process organonitrogen compound metabolic process regulation of protein dephosphorylation biological regulation positive regulation of catalytic activity positive regulation of protein dephosphorylation regulation of macromolecule metabolic process positive regulation of hydrolase activity cellular process cellular response to stimulus activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway response to stimulus signaling negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of activin receptor signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway regulation of activin receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway protein localization multicellular organismal process cellular localization postsynaptic membrane assembly membrane biogenesis cellular component organization cellular component biogenesis multicellular organism development localization cellular component assembly cell junction assembly receptor clustering cellular macromolecule localization anatomical structure development synapse organization cellular component organization or biogenesis postsynaptic membrane organization system development developmental process membrane organization postsynapse organization postsynapse assembly neuroligin clustering involved in postsynaptic membrane assembly nervous system development localization within membrane protein localization to membrane membrane assembly cell junction organization macromolecule localization synapse assembly cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization generation of neurons neuron development regulation of plasma membrane bounded cell projection organization negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell adhesion regulation of synaptic membrane adhesion regulation of synapse organization cell adhesion cell-cell adhesion regulation of synapse structure or activity regulation of cell-cell adhesion regulation of biological quality synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules nerve growth factor signaling pathway neurotrophin signaling pathway regulation of localization import into cell receptor internalization transport regulation of receptor internalization vesicle-mediated transport positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis renal filtration cell differentiation kidney epithelium development glomerular epithelial cell differentiation epithelial cell differentiation renal system development nephron development nephron epithelium development epithelial cell differentiation involved in kidney development epithelium development animal organ development glomerular epithelium development tissue development glomerulus development podocyte development epithelial cell development cell differentiation involved in kidney development glomerular epithelial cell development podocyte differentiation kidney development vesicle localization synaptic vesicle clustering synaptic vesicle cycle vesicle-mediated transport in synapse organelle localization establishment of localization in cell positive regulation of synaptic vesicle clustering regulation of synaptic vesicle clustering synaptic vesicle localization clathrin-dependent endocytosis protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane regulation of protein localization to cell periphery protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse SMAD protein signal transduction negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation	cell-cell junction anchoring junction cell junction cellular anatomical entity photoreceptor inner segment extrinsic component of plasma membrane synapse membrane plasma membrane synaptic membrane cell periphery extrinsic component of synaptic membrane postsynapse postsynaptic membrane cell-cell junction anchoring junction cell junction cellular anatomical entity photoreceptor inner segment extrinsic component of plasma membrane synapse membrane plasma membrane synaptic membrane cell periphery extrinsic component of synaptic membrane postsynapse postsynaptic membrane plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm glutamatergic synapse membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium organelle perinuclear region of cytoplasm intracellular organelle centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle filtration diaphragm slit diaphragm centriole protein-containing complex GABA-ergic synapse postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse apical junction complex bicellular tight junction tight junction endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle late endosome vesicle ciliary base nucleus
C, D	Peptide from Dendrin	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding	regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane somatodendritic compartment cell body perikaryon neuronal cell body dendritic spine neuron projection membrane dendrite membrane dendritic tree cell leading edge neuron spine neuron projection leading edge membrane plasma membrane bounded cell projection dendritic spine membrane cell projection dendrite cell projection membrane intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036020	WW domain superfamily	Homologous Superfamily
A, B	IPR020590	Guanylate kinase, conserved site	Conserved Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR008144	Guanylate kinase-like domain	Domain
A, B	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR001478	PDZ domain	Domain
A, B	IPR001202	WW domain	Domain
C, D	IPR026500	Dendrin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.