6JBM

Crystal structure of the TRIM14 PRYSPRY domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	PRY/SPRY domain	8099165	4001665	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8099166	3000120	SCOP2 (2022-06-29)
B [auth A]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8099166	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8099166	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8099166	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF00622,PF13765	e6jbmB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00622,PF13765	ECOD (1.6)
B [auth A]	PF00622,PF13765	e6jbmA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00622,PF13765	ECOD (1.6)
C	PF00622,PF13765	e6jbmC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00622,PF13765	ECOD (1.6)
D	PF00622,PF13765	e6jbmD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00622,PF13765	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D	PF00622	SPRY domain (SPRY)	SPRY domain	-	Family
A [auth B], B [auth A], C, D	PF13765	SPRY-associated domain (PRY)	SPRY-associated domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D	Tripartite motif-containing protein 14	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity	positive regulation of DNA-binding transcription factor activity regulation of cellular process cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process positive regulation of DNA-binding transcription factor activity regulation of cellular process cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process viral gene expression regulation of viral process negative regulation of viral process regulation of viral transcription negative regulation of viral transcription viral process negative regulation of biological process viral transcription response to stimulus defense response response to stress inflammatory response biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus organonitrogen compound metabolic process protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane membrane-bounded organelle intracellular anatomical structure mitochondrial membrane mitochondrion membrane organelle outer membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane cytoplasm organelle membrane intracellular vesicle phagocytic vesicle cytoplasmic vesicle vesicle endocytic vesicle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D	IPR000315	B-box-type zinc finger	Domain
A [auth B], B [auth A], C, D	IPR001870	B30.2/SPRY domain	Domain
A [auth B], B [auth A], C, D	IPR006574	SPRY-associated	Domain
A [auth B], B [auth A], C, D	IPR003879	Butyrophylin-like, SPRY domain	Domain
A [auth B], B [auth A], C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D	IPR044116	TRIM14, PRY/SPRY domain	Domain
A [auth B], B [auth A], C, D	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D	IPR003877	SPRY domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A], C, D	Pharos: Q14142	pilocytic astrocytoma rheumatoid arthritis astrocytic tumor glioblastoma lung cancer malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primary biliary cholangitis Sjogren syndrome cutaneous lupus erythematosus invasive ductal breast carcinoma lymphoplasmacytic lymphoma malignant glioma pilocytic astrocytoma rheumatoid arthritis astrocytic tumor glioblastoma lung cancer malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primary biliary cholangitis Sjogren syndrome cutaneous lupus erythematosus invasive ductal breast carcinoma lymphoplasmacytic lymphoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis tuberculosis ductal breast carcinoma in situ juvenile dermatomyositis malignant colon neoplasm malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.