6J55

Crystal structure of an iron superoxide dismutate (FeSOD) from a pathogenic Acanthamoeba castellanii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
K	d6j55k1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
K	d6j55k2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
A	d6j55a1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
A	d6j55a2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
A	d6j55a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
B	d6j55b1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
B	d6j55b2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
B	d6j55b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
C	d6j55c1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
C	d6j55c2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
C	d6j55c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
D	d6j55d1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
D	d6j55d2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
D	d6j55d3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
E	d6j55e1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
E	d6j55e2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
F	d6j55f1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
F	d6j55f2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
G	d6j55g1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
G	d6j55g2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
H	d6j55h1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
H	d6j55h2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
I	d6j55i1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
I	d6j55i2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
J	d6j55j1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
J	d6j55j2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
L	d6j55l1	All alpha proteins	Long alpha-hairpin	Fe,Mn superoxide dismutase (SOD), N-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
L	d6j55l2	Alpha and beta proteins (a+b)	Fe,Mn superoxide dismutase (SOD), C-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	automated matches	automated matches	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)
L	d6j55l3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Amoeba (Acanthamoeba castellanii ) [TaxId: 5755 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
K	PF00081	e6j55K1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
K	PF02777	e6j55K2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
A	PF00081	e6j55A1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
A	PF02777	e6j55A2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
B	PF00081	e6j55B1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
B	PF02777	e6j55B2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
C	PF00081	e6j55C1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
C	PF02777	e6j55C2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
D	PF00081	e6j55D2	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
D	PF02777	e6j55D1	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
E	PF00081	e6j55E1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
E	PF02777	e6j55E2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
F	PF00081	e6j55F1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
F	PF02777	e6j55F2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
G	PF00081	e6j55G1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
G	PF02777	e6j55G2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
H	PF00081	e6j55H2	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
H	PF02777	e6j55H1	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
I	PF00081	e6j55I2	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
I	PF02777	e6j55I1	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
J	PF00081	e6j55J2	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
J	PF02777	e6j55J1	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)
L	PF00081	e6j55L1	A: alpha bundles	X: Long alpha-hairpin	H: Fe,Mn superoxide dismutase (SOD), N-terminal domain (From Topology)	T: Fe,Mn superoxide dismutase (SOD), N-terminal domain	F: PF00081	ECOD (1.6)
L	PF02777	e6j55L2	A: a+b three layers	X: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	H: Fe,Mn superoxide dismutase (SOD)-C (From Topology)	T: Fe,Mn superoxide dismutase (SOD)-C	F: PF02777	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00081	Iron/manganese superoxide dismutases, alpha-hairpin domain (Sod_Fe_N)	Iron/manganese superoxide dismutases, alpha-hairpin domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytopla ...	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF02777	Iron/manganese superoxide dismutases, C-terminal domain (Sod_Fe_C)	Iron/manganese superoxide dismutases, C-terminal domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplas ...	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Superoxide dismutase	cation binding ion binding binding metal ion binding small molecule binding superoxide dismutase activity oxidoreductase activity, acting on superoxide radicals as acceptor oxidoreductase activity antioxidant activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036324	Manganese/iron superoxide dismutase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001189	Manganese/iron superoxide dismutase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR019833	Manganese/iron superoxide dismutase, binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR019832	Manganese/iron superoxide dismutase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR019831	Manganese/iron superoxide dismutase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036314	Manganese/iron superoxide dismutase, C-terminal domain superfamily	Homologous Superfamily