Annotations: 6J2L

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PRA-CH	e6j2lA1	A: beta barrels	X: Ribosomal protein L25-like	H: HisI-like (From Topology)	T: HisI-like	F: PRA-CH	ECOD (1.6)
A	PRA-PH_1	e6j2lA2	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: MazG-related	F: PRA-PH_1	ECOD (1.6)
B	PRA-CH	e6j2lB1	A: beta barrels	X: Ribosomal protein L25-like	H: HisI-like (From Topology)	T: HisI-like	F: PRA-CH	ECOD (1.6)
B	PRA-PH_1	e6j2lB2	A: alpha bundles	X: all-alpha NTP pyrophosphatases (From Homology)	H: all-alpha NTP pyrophosphatases	T: MazG-related	F: PRA-PH_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01503	Phosphoribosyl-ATP pyrophosphohydrolase (PRA-PH)	Phosphoribosyl-ATP pyrophosphohydrolase	-	Family
A, B	PF01502	Phosphoribosyl-AMP cyclohydrolase (PRA-CH)	Phosphoribosyl-AMP cyclohydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Histidine biosynthesis bifunctional protein HisIE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines phosphoribosyl-AMP cyclohydrolase activity cyclohydrolase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides phosphoribosyl-ATP diphosphatase activity	organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process histidine metabolic process histidine biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR021130	Phosphoribosyl-ATP pyrophosphohydrolase-like	Family
A, B	IPR002496	Phosphoribosyl-AMP cyclohydrolase domain	Domain
A, B	IPR038019	Phosphoribosyl-AMP cyclohydrolase domain superfamily	Homologous Superfamily
A, B	IPR008179	Phosphoribosyl-ATP pyrophosphohydrolase	Family
A, B	IPR023019	Histidine biosynthesis bifunctional protein HisIE	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.