Annotations: 6IRE

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00595	e6ireB2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06631	Protein of unknown function (DUF1154) (DUF1154)	Protein of unknown function (DUF1154)	-	Family
B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity lipase activity	rhythmic process circadian rhythm adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior cellular metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process rhythmic process circadian rhythm adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior cellular metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling negative regulation of signaling regulation of opsin-mediated signaling pathway negative regulation of biological process regulation of signal transduction detection of abiotic stimulus negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cellular response to environmental stimulus cell communication cellular response to light stimulus negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway rhodopsin mediated signaling pathway negative regulation of opsin-mediated signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation response to external stimulus detection of visible light cellular response to radiation negative regulation of signal transduction detection of stimulus regulation of response to stimulus negative regulation of response to external stimulus regulation of cell communication response to radiation response to abiotic stimulus G protein-coupled receptor signaling pathway cellular response to abiotic stimulus phototransduction, visible light entrainment of circadian clock regulation of circadian rhythm compound eye retinal cell programmed cell death cellular developmental process regulation of developmental process sensory organ development visual system development cell development regulation of programmed cell death eye morphogenesis multicellular organism development compound eye morphogenesis cell differentiation regulation of retinal cell programmed cell death anatomical structure development negative regulation of compound eye retinal cell programmed cell death animal organ morphogenesis sensory system development system development developmental process negative regulation of programmed cell death eye development negative regulation of developmental process animal organ development cell death programmed cell death involved in cell development anatomical structure morphogenesis regulation of compound eye retinal cell programmed cell death compound eye development sensory organ morphogenesis retinal cell programmed cell death programmed cell death negative regulation of retinal cell programmed cell death intracellular signal transduction calcium-mediated signaling intracellular signaling cassette lipid biosynthetic process phospholipid biosynthetic process biosynthetic process organophosphate biosynthetic process organic substance biosynthetic process system process nervous system process detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of taste sensory perception of chemical stimulus sensory perception sensory perception of taste response to chemical detection of chemical stimulus sensory perception of bitter taste detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception phosphatidylinositol-mediated signaling lipid catabolic process catabolic process organic substance catabolic process photoperiodism entrainment of circadian clock by photoperiod multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis retina homeostasis photoreceptor cell maintenance phospholipase C-activating G protein-coupled receptor signaling pathway regulation of localization cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis transport monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport localization intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport immune response immune system process mucosal immune response organ or tissue specific immune response sensory perception of light stimulus visual perception neutral lipid metabolic process diacylglycerol biosynthetic process neutral lipid biosynthetic process cellular biosynthetic process acylglycerol biosynthetic process diacylglycerol metabolic process glycerolipid biosynthetic process glycerolipid metabolic process acylglycerol metabolic process phosphatidylinositol metabolic process glycerophospholipid metabolic process import into cell regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process vesicle-mediated transport cellular component organization positive regulation of endocytosis clathrin-dependent endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of transport positive regulation of clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis regulation of clathrin-dependent endocytosis taxis thermotaxis response to temperature stimulus locomotion	cell projection rhabdomere cellular anatomical entity plasma membrane bounded cell projection protein-containing complex extrinsic component of plasma membrane plasma membrane protein complex membrane plasma membrane membrane protein complex inaD signaling complex cell periphery extrinsic component of membrane
B	Inactivation-no-after-potential D protein	cytoskeletal protein binding protein binding binding myosin binding myosin III binding calmodulin binding molecular transducer activity photoreceptor activity signaling receptor activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling negative regulation of signaling regulation of opsin-mediated signaling pathway negative regulation of biological process regulation of signal transduction detection of abiotic stimulus negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cellular response to environmental stimulus cell communication cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling negative regulation of signaling regulation of opsin-mediated signaling pathway negative regulation of biological process regulation of signal transduction detection of abiotic stimulus negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cellular response to environmental stimulus cell communication cellular response to light stimulus negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway rhodopsin mediated signaling pathway negative regulation of opsin-mediated signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation response to external stimulus detection of visible light cellular response to radiation negative regulation of signal transduction detection of stimulus regulation of response to stimulus negative regulation of response to external stimulus regulation of cell communication response to radiation response to abiotic stimulus cellular process G protein-coupled receptor signaling pathway cellular response to abiotic stimulus phototransduction, visible light protein localization localization cellular localization cellular macromolecule localization macromolecule localization multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus sensory perception of light stimulus visual perception detection of light stimulus involved in sensory perception detection of stimulus involved in sensory perception	cell projection rhabdomere cellular anatomical entity plasma membrane bounded cell projection protein-containing complex extrinsic component of plasma membrane plasma membrane protein complex membrane plasma membrane membrane protein complex inaD signaling complex cell periphery extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta	Family
A	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	Domain
A	IPR009535	Phospholipase C-beta, conserved site	Conserved Site
A	IPR000008	C2 domain	Domain
A	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Domain
A	IPR001192	Phosphoinositide phospholipase C family	Family
A	IPR042531	Phospholipase C-beta, C-terminal domain superfamily	Homologous Superfamily
A	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Homologous Superfamily
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR037862	PLC-beta, PH domain	Domain
B	IPR036034	PDZ superfamily	Homologous Superfamily
B	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.