Annotations: 6IRD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth C]	d6irdc1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth C]	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF06631	Protein of unknown function (DUF1154) (DUF1154)	Protein of unknown function (DUF1154)	-	Family
B [auth C]	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity lipase activity protein binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding	negative regulation of potassium ion transport regulation of localization regulation of biological process regulation of potassium ion transport transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport biological regulation negative regulation of biological process negative regulation of transport establishment of localization metal ion transport localization monoatomic ion transport negative regulation of potassium ion transport regulation of localization regulation of biological process regulation of potassium ion transport transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport biological regulation negative regulation of biological process negative regulation of transport establishment of localization metal ion transport localization monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport cellular response to stimulus regulation of cellular process response to stimulus signaling intracellular signal transduction cell communication phosphatidylinositol-mediated signaling cellular process signal transduction trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport maintenance of location in cell monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis monoatomic cation homeostasis regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport	parallel fiber to Purkinje cell synapse synapse cell junction cellular anatomical entity excitatory synapse membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system parallel fiber to Purkinje cell synapse synapse cell junction cellular anatomical entity excitatory synapse membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum smooth endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse nucleus
B [auth C]	InaD-like protein	-	cellular component organization organelle organization microtubule organizing center organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization tight junction organization cellular component biogenesis cell junction organization cellular component assembly tight junction assembly cell junction assembly cellular component organization organelle organization microtubule organizing center organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization tight junction organization cellular component biogenesis cell junction organization cellular component assembly tight junction assembly cell junction assembly cell-cell junction assembly cell-cell junction organization establishment of cell polarity establishment or maintenance of bipolar cell polarity establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity establishment of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction intracellular signal transduction cell communication establishment or maintenance of epithelial cell apical/basal polarity regulation of cytoskeleton organization regulation of cellular component organization regulation of microtubule-based process regulation of organelle organization regulation of microtubule cytoskeleton organization	cell junction cellular anatomical entity apical part of cell cell periphery membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle cell junction cellular anatomical entity apical part of cell cell periphery membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta	Family
A [auth B]	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	Domain
A [auth B]	IPR009535	Phospholipase C-beta, conserved site	Conserved Site
A [auth B]	IPR000008	C2 domain	Domain
A [auth B]	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	Domain
A [auth B]	IPR011992	EF-hand domain pair	Homologous Superfamily
A [auth B]	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Domain
A [auth B]	IPR001192	Phosphoinositide phospholipase C family	Family
A [auth B]	IPR042531	Phospholipase C-beta, C-terminal domain superfamily	Homologous Superfamily
A [auth B]	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Homologous Superfamily
A [auth B]	IPR035892	C2 domain superfamily	Homologous Superfamily
A [auth B]	IPR037862	PLC-beta, PH domain	Domain
B [auth C]	IPR004172	L27 domain	Domain
B [auth C]	IPR036034	PDZ superfamily	Homologous Superfamily
B [auth C]	IPR036892	L27 domain superfamily	Homologous Superfamily
B [auth C]	IPR001478	PDZ domain	Domain
B [auth C]	IPR015132	L27-2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth C]	Pharos: Q8NI35	prostate cancer Prostatic Neoplasms spina bifida substance-related disorder ulcerative colitis colorectal cancer drug dependence Duchenne muscular dystrophy limb-girdle muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma substance dependence cutaneous lupus erythematosus interstitial cystitis prostate cancer Prostatic Neoplasms spina bifida substance-related disorder ulcerative colitis colorectal cancer drug dependence Duchenne muscular dystrophy limb-girdle muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma psoriasis subependymal giant cell astrocytoma substance dependence cutaneous lupus erythematosus interstitial cystitis lung cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm sarcoidosis substance abuse tuberculosis interstitial lung disease malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.