6IIE

Crystal structure of human diacylglycerol kinase alpha EF-hand domains bound to Ca2+

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6iieA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Diacylglycerol kinase alpha	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups alkylglycerol kinase activity phosphotransferase activity, alcohol group as acceptor phospholipid binding lipid binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups alkylglycerol kinase activity phosphotransferase activity, alcohol group as acceptor phospholipid binding lipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding lipid kinase activity ATP-dependent diacylglycerol kinase activity	cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process phosphorus metabolic process phosphatidic acid biosynthetic process glycerophospholipid biosynthetic process phosphatidic acid metabolic process cellular metabolic process primary metabolic process phospholipid biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process phosphorus metabolic process phosphatidic acid biosynthetic process glycerophospholipid biosynthetic process phosphatidic acid metabolic process cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process metabolic process cellular process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation protein kinase C-activating G protein-coupled receptor signaling pathway cell communication G protein-coupled receptor signaling pathway signal transduction neutral lipid metabolic process diacylglycerol metabolic process acylglycerol metabolic process lipid phosphorylation phosphorylation lipid modification multicellular organismal process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation intracellular signal transduction	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029477	Diacylglycerol kinase type I, N-terminal	Domain
A	IPR038199	DGK type I, N-terminal domain superfamily	Homologous Superfamily
A	IPR000756	Diacylglycerol kinase, accessory domain	Domain
A	IPR047469	Diacylglycerol kinase alpha, second protein kinase C conserved region 1	Domain
A	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily	Homologous Superfamily
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR017438	Inorganic polyphosphate/ATP-NAD kinase, N-terminal	Homologous Superfamily
A	IPR001206	Diacylglycerol kinase, catalytic domain	Domain
A	IPR037607	Diacylglycerol kinase	Family
A	IPR046349	C1-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23743	rheumatoid arthritis allergic rhinitis Crohn disease Hashimoto thyroiditis malignant mesothelioma osteosarcoma psoriasis alopecia areata esophageal adenocarcinoma hypothyroidism malignant pancreatic neoplasm pancreatic ductal adenocarcinoma cleft lip gastroesophageal reflux disease large cell medulloblastoma rheumatoid arthritis allergic rhinitis Crohn disease Hashimoto thyroiditis malignant mesothelioma osteosarcoma psoriasis alopecia areata esophageal adenocarcinoma hypothyroidism malignant pancreatic neoplasm pancreatic ductal adenocarcinoma cleft lip gastroesophageal reflux disease large cell medulloblastoma non-small cell lung carcinoma polycystic ovary syndrome vitiligo

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.