6IEC

Structure of RVFV Gn and human monoclonal antibody R17

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07243	e6iecA1	A: beta complex topology	X: Phlebovirus glycoprotein Gn (From Topology)	H: Phlebovirus glycoprotein Gn (From Topology)	T: Phlebovirus glycoprotein Gn	F: PF07243	ECOD (1.6)
D [auth B]	PF07243	e6iecB1	A: beta complex topology	X: Phlebovirus glycoprotein Gn (From Topology)	H: Phlebovirus glycoprotein Gn (From Topology)	T: Phlebovirus glycoprotein Gn	F: PF07243	ECOD (1.6)
G [auth E]	PF07243	e6iecE1	A: beta complex topology	X: Phlebovirus glycoprotein Gn (From Topology)	H: Phlebovirus glycoprotein Gn (From Topology)	T: Phlebovirus glycoprotein Gn	F: PF07243	ECOD (1.6)
J [auth I]	PF07243	e6iecI1	A: beta complex topology	X: Phlebovirus glycoprotein Gn (From Topology)	H: Phlebovirus glycoprotein Gn (From Topology)	T: Phlebovirus glycoprotein Gn	F: PF07243	ECOD (1.6)
B [auth H]	PF07686	e6iecH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E [auth C]	PF07686	e6iecC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H [auth F]	PF07686	e6iecF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
K [auth J]	PF07686	e6iecJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth L]	PF07686	e6iecL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth D]	PF07686	e6iecD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
I [auth G]	PF07686	e6iecG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
L [auth K]	PF07686	e6iecK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth H], E [auth C], H [auth F], K [auth J]	Fab R17, neutralizing antibody	VH	Homo sapiens (human)	IGHV3-1101, IGHV3-1104, IGHJ5*02	V-DOMAIN VH	IG	VH-V-LAMBDA	IMGT (202417-0)
C [auth L], F [auth D], I [auth G], L [auth K]	Fab R17, neutralizing antibody	V-LAMBDA	Homo sapiens (human)	IGLV3-2103, IGLJ101	V-DOMAIN V-LAMBDA	IG	VH-V-LAMBDA	IMGT (202417-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H], E [auth C], H [auth F], K [auth J]	Heavy Chain	IGHV3	-	nsmgngc	SAbDab (2024-05-03)
C [auth L], F [auth D], I [auth G], L [auth K]	Light Chain	IGLV3	Lambda	nsmgngc	SAbDab (2024-05-03)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth B], G [auth E], J [auth I]	PF07243	Phlebovirus glycoprotein G1 (Phlebovirus_G1)	Phlebovirus glycoprotein G1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth B], G [auth E], J [auth I]	NSmGnGc	-	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	membrane cellular anatomical entity virion component virion membrane host cellular component host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell mitochondrion host cell cytoplasm part host intracellular organelle host organelle outer membrane host cell cytoplasm host cell part membrane cellular anatomical entity virion component virion membrane host cellular component host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell mitochondrion host cell cytoplasm part host intracellular organelle host organelle outer membrane host cell cytoplasm host cell part host cell mitochondrial envelope host intracellular region host cell mitochondrial outer membrane host cell mitochondrial membrane host outer membrane host cell endoplasmic reticulum host cell endomembrane system host cell endoplasmic reticulum membrane host cell Golgi membrane host cell Golgi apparatus
B [auth H], E [auth C], H [auth F], K [auth J]	R17 H chain	-	-	-
C [auth L], F [auth D], I [auth G], L [auth K]	R17 L chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth B], G [auth E], J [auth I]	IPR009879	Phlebovirus nonstructural NS-M	Domain
A, D [auth B], G [auth E], J [auth I]	IPR009878	Phlebovirus glycoprotein G2, fusion domain	Domain
A, D [auth B], G [auth E], J [auth I]	IPR010826	Phlebovirus glycoprotein G1	Domain
A, D [auth B], G [auth E], J [auth I]	IPR016404	M polyprotein precursor, phlebovirus	Family
A, D [auth B], G [auth E], J [auth I]	IPR043603	Phlebovirus glycoprotein G2, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.