6I5J

Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SOCS box-like	8032737	3001002	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SH2 domain	8032739	3000197	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ubiquitin-like	8038575	3000157	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ubiquitin-like	8038575	3000157	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SH2 domain	8032739	3000197	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SOCS box-like	8032737	3001002	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07525	e6i5jA2	A: alpha arrays	X: SOCS box-like (From Topology)	H: SOCS box-like (From Topology)	T: SOCS box-like	F: PF07525	ECOD (1.6)
A	PF00017	e6i5jA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)
B	PF00240	e6i5jB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF00240	ECOD (1.6)
E	PF00240	e6i5jE1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF00240	ECOD (1.6)
C	PF03931	e6i5jC1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF03931	ECOD (1.6)
F	PF03931	e6i5jF1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF03931	ECOD (1.6)
D	PF07525	e6i5jD2	A: alpha arrays	X: SOCS box-like (From Topology)	H: SOCS box-like (From Topology)	T: SOCS box-like	F: PF07525	ECOD (1.6)
D	PF00017	e6i5jD1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.750.20	Mainly Alpha	Orthogonal Bundle	Elongin C	Chain C, domain 1	CATH (utative)
B	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (utative)
E	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (utative)
C	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (utative)
F	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (utative)
D	1.10.750.20	Mainly Alpha	Orthogonal Bundle	Elongin C	Chain C, domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
A	PF07525	SOCS box (SOCS_box)	SOCS box	The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.	Domain
B, E	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
C, F	PF03931	Skp1 family, tetramerisation domain (Skp1_POZ)	Skp1 family, tetramerisation domain	-	Domain
D	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
D	PF07525	SOCS box (SOCS_box)	SOCS box	The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Suppressor of cytokine signaling 2	enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity protein-macromolecule adaptor activity JAK pathway signal transduction adaptor activity molecular adaptor activity signaling adaptor activity growth hormone receptor binding protein binding binding signaling receptor binding cytokine receptor binding hormone receptor binding enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity protein-macromolecule adaptor activity JAK pathway signal transduction adaptor activity molecular adaptor activity signaling adaptor activity growth hormone receptor binding protein binding binding signaling receptor binding cytokine receptor binding hormone receptor binding insulin-like growth factor receptor binding	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular biosynthetic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication signal transduction regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis response to organic substance response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to organic substance cellular response to hormone stimulus organonitrogen compound metabolic process protein ubiquitination macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process regulation of multicellular organism growth multicellular organismal process regulation of developmental growth negative regulation of multicellular organism growth regulation of developmental process developmental growth negative regulation of developmental process multicellular organism growth negative regulation of developmental growth negative regulation of growth regulation of multicellular organismal process negative regulation of multicellular organismal process cell surface receptor signaling pathway via STAT negative regulation of signaling negative regulation of cell communication regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway growth hormone receptor signaling pathway response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to organonitrogen compound cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process system development nervous system development generation of neurons regulation of neuron differentiation regulation of body fluid levels secretion transport mammary gland development gland development animal organ development establishment of localization body fluid secretion localization lactation regulation of biological quality intracellular signal transduction mammary gland lobule development mammary gland alveolus development response to lipid response to estradiol response to organic cyclic compound	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane membrane protein complex transferase complex extrinsic component of membrane
B, E	Elongin-B	transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression organic substance biosynthetic process miRNA metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression organic substance biosynthetic process miRNA metabolic process RNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process catabolic process cellular biosynthetic process RNA metabolic process macromolecule catabolic process organic substance metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process miRNA catabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process target-directed miRNA degradation regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process negative regulation of biosynthetic process ncRNA metabolic process organic substance catabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter nucleobase-containing compound biosynthetic process DNA-templated transcription initiation organic cyclic compound biosynthetic process transcription elongation by RNA polymerase II DNA-templated transcription elongation positive regulation of proteasomal protein catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity elongin complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity elongin complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol cytoplasmic ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex VCB complex cullin-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex
C, F	Elongin-C	transcription factor binding transcription coregulator binding transcription corepressor binding protein binding binding protein-macromolecule adaptor activity molecular adaptor activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression organic substance biosynthetic process miRNA metabolic process RNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process cellular biosynthetic process RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process miRNA catabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process target-directed miRNA degradation regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process negative regulation of biosynthetic process ncRNA metabolic process cellular process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter nucleobase-containing compound biosynthetic process DNA-templated transcription initiation organic cyclic compound biosynthetic process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of DNA-templated transcription protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity elongin complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity elongin complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex Cul5-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex
D	Suppressor of cytokine signaling 2	enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity protein-macromolecule adaptor activity JAK pathway signal transduction adaptor activity molecular adaptor activity signaling adaptor activity growth hormone receptor binding protein binding binding signaling receptor binding cytokine receptor binding hormone receptor binding enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity protein-macromolecule adaptor activity JAK pathway signal transduction adaptor activity molecular adaptor activity signaling adaptor activity growth hormone receptor binding protein binding binding signaling receptor binding cytokine receptor binding hormone receptor binding insulin-like growth factor receptor binding	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular biosynthetic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication signal transduction regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis response to organic substance response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to organic substance cellular response to hormone stimulus organonitrogen compound metabolic process protein ubiquitination macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process regulation of multicellular organism growth multicellular organismal process regulation of developmental growth negative regulation of multicellular organism growth regulation of developmental process developmental growth negative regulation of developmental process multicellular organism growth negative regulation of developmental growth negative regulation of growth regulation of multicellular organismal process negative regulation of multicellular organismal process cell surface receptor signaling pathway via STAT negative regulation of signaling negative regulation of cell communication regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway growth hormone receptor signaling pathway response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to organonitrogen compound cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process system development nervous system development generation of neurons regulation of neuron differentiation regulation of body fluid levels secretion transport mammary gland development gland development animal organ development establishment of localization body fluid secretion localization lactation regulation of biological quality intracellular signal transduction mammary gland lobule development mammary gland alveolus development response to lipid response to estradiol response to organic cyclic compound	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane membrane protein complex transferase complex extrinsic component of membrane
G [auth I], H [auth J], I [auth K], J [auth L]	Growth hormone receptor peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR028410	Suppressor of cytokine signalling 2, SOCS box domain	Domain
A	IPR036036	SOCS box-like domain superfamily	Homologous Superfamily
A	IPR001496	SOCS box domain	Domain
A	IPR035862	SOCS2, SH2 domain	Domain
B, E	IPR000626	Ubiquitin-like domain	Domain
B, E	IPR039049	Elongin B	Family
B, E	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
C, F	IPR016073	SKP1 component, POZ domain	Domain
C, F	IPR001232	S-phase kinase-associated protein 1-like	Family
C, F	IPR039948	Elongin-C	Family
C, F	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
D	IPR036860	SH2 domain superfamily	Homologous Superfamily
D	IPR000980	SH2 domain	Domain
D	IPR028410	Suppressor of cytokine signalling 2, SOCS box domain	Domain
D	IPR036036	SOCS box-like domain superfamily	Homologous Superfamily
D	IPR001496	SOCS box domain	Domain
D	IPR035862	SOCS2, SH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O14508	narcolepsy allergic contact dermatitis Liver Cirrhosis, Experimental narcolepsy-cataplexy syndrome pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis adrenal cortex carcinoma ulcerative colitis breast cancer glioblastoma large cell medulloblastoma lung cancer malignant ependymoma medulloblastoma narcolepsy allergic contact dermatitis Liver Cirrhosis, Experimental narcolepsy-cataplexy syndrome pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis adrenal cortex carcinoma ulcerative colitis breast cancer glioblastoma large cell medulloblastoma lung cancer malignant ependymoma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma schizophrenia breast carcinoma hepatocellular carcinoma lung carcinoma malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor cystic fibrosis invasive ductal breast carcinoma lung adenocarcinoma malignant colon neoplasm malignant mesothelioma
B, E	Pharos: Q15370	acute myeloid leukemia ovarian cancer diabetes mellitus plasma cell myeloma lymphoplasmacytic lymphoma
C, F	Pharos: Q15369	papillary renal cell carcinoma sarcomatoid renal cell carcinoma collecting duct carcinoma chromophobe renal cell carcinoma renal cell carcinoma astrocytic tumor clear cell renal carcinoma dermatomyositis breast cancer invasive ductal breast carcinoma plasma cell myeloma Conventional (Clear Cell) Renal Cell Carcinoma ovarian cancer
D	Pharos: O14508	narcolepsy allergic contact dermatitis Liver Cirrhosis, Experimental narcolepsy-cataplexy syndrome pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis adrenal cortex carcinoma ulcerative colitis breast cancer glioblastoma large cell medulloblastoma lung cancer malignant ependymoma medulloblastoma narcolepsy allergic contact dermatitis Liver Cirrhosis, Experimental narcolepsy-cataplexy syndrome pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis adrenal cortex carcinoma ulcerative colitis breast cancer glioblastoma large cell medulloblastoma lung cancer malignant ependymoma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma schizophrenia breast carcinoma hepatocellular carcinoma lung carcinoma malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor cystic fibrosis invasive ductal breast carcinoma lung adenocarcinoma malignant colon neoplasm malignant mesothelioma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CAS	Parent Component: CYS
B, E	CAS	Parent Component: CYS
D	CAS	Parent Component: CYS
G [auth I], H [auth J], I [auth K], J [auth L]	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048
G [auth I], H [auth J], I [auth K], J [auth L]	VLM	RESID: AA0039

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.