6HUX

HmdII from Methanocaldococcus jannaschii reconstitued with Fe-guanylylpyridinol (FeGP) cofactor and co-crystallized with methenyl-tetrahydromethanopterin at 2.5 A resolution

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF03201e6huxA2 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: PF03201ECOD (1.6)
APF22616e6huxA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: PF22616ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF03201H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase (HMD)H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR038182HMD, C-terminal domain superfamilyHomologous Superfamily
IPR024190Methenyltetrahydromethanopterin dehydrogenase, Hmd-typeFamily
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
IPR010063H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related proteinFamily
IPR004889H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminalDomain
IPR0089276-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyHomologous Superfamily