6HUM

Structure of the photosynthetic complex I from Thermosynechococcus elongatus

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I [auth H]	SCOP2 Family	Nqo4-like	8085740	4000433	SCOP2 (2022-06-29)
I [auth H]	SCOP2 Superfamily	HydB/Nqo4-like	8085741	3001849	SCOP2 (2022-06-29)
M [auth F]	SCOP2 Family	ND5 antiporter-like subunits	8059303	4005931	SCOP2 (2022-06-29)
M [auth F]	SCOP2 Superfamily	Antiporter subunits half-channel-like	8059304	3002280	SCOP2 (2022-06-29)
M [auth F]	SCOP2 Superfamily	Antiporter subunits half-channel-like	8093351	3002280	SCOP2 (2022-06-29)
P [auth S]	SCOP2B Superfamily	Electron transport accessory proteins	8103000	3000325	SCOP2B (2022-06-29)
B [auth C]	SCOP2 Family	NADH-ubiquinone oxidoreductase chain 3-like	8067560	4005842	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Superfamily	NADH-quinone oxidoreductase subunit 11-like	8106707	3002200	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Family	ND4 antiporter-like subunits	8059299	4005749	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Antiporter subunits half-channel-like	8059300	3002280	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Antiporter subunits half-channel-like	8093348	3002280	SCOP2 (2022-06-29)
D [auth E]	SCOP2 Family	NADH-quinone oxidoreductase NDH subunit 11-like	8060882	4005793	SCOP2 (2022-06-29)
D [auth E]	SCOP2 Superfamily	NADH-quinone oxidoreductase subunit 11-like	8060883	3002200	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth B]	PF00361,PF19530	e6humB1	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: PF00361,PF19530	ECOD (1.6)
I [auth H]	PF00346	e6humH2	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: PF00346	ECOD (1.6)
I [auth H]	PF00346	e6humH1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: PF00346	ECOD (1.6)
Q [auth O]	PF11910	e6humO1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF11910	ECOD (1.6)
A	PF00146	e6humA1	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit 8 (Nqo8)-related	F: PF00146	ECOD (1.6)
J [auth I]	PF00037	e6humI1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037	ECOD (1.6)
M [auth F]	PF00361,PF00662,PF01010	e6humF1	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: PF00361,PF00662,PF01010	ECOD (1.6)
P [auth S]	PF11623	e6humS1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF11623	ECOD (1.6)
B [auth C]	PF00507	e6humC1	A: extended segments	X: NADH-quinone oxidoreductase subunit A (From Topology)	H: NADH-quinone oxidoreductase subunit A (From Topology)	T: NADH-quinone oxidoreductase subunit A	F: PF00507	ECOD (1.6)
C [auth D]	PF00361	e6humD1	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: PF00361	ECOD (1.6)
D [auth E]	PF00420	e6humE1	A: alpha complex topology	X: NADH-quinone oxidoreductase subunit K (From Topology)	H: NADH-quinone oxidoreductase subunit K (From Topology)	T: NADH-quinone oxidoreductase subunit K	F: PF00420	ECOD (1.6)
F [auth G]	PF00499	e6humG1	A: extended segments	X: NADH-quinone oxidoreductase subunit J (From Topology)	H: NADH-quinone oxidoreductase subunit J (From Topology)	T: NADH-quinone oxidoreductase subunit J	F: PF00499	ECOD (1.6)
G [auth J]	PF00329	e6humJ1	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: PF00329	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
I [auth H]	1.10.645.10	Mainly Alpha	Orthogonal Bundle	Cytochrome-c3 Hydrogenase	chain B	CATH (utative)
P [auth S]	2.30.30.140	Mainly Beta	Roll	SH3 type barrels.		CATH (4.3.0)
B [auth C]	1.20.58.1610	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D [auth E]	1.10.287.3510	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth B]	PF19530	NAD(P)H-quinone oxidoreductase subunit 2 N-terminal (Ndh2_N)	NAD(P)H-quinone oxidoreductase subunit 2 N-terminal	This domain represents the N-terminal of NAD(P)H-quinone oxidoreductase subunit 2 (or subunit B), part of the P-module (pumping) of the photosynthetic complex I from plants and cyanobacteria, which is structurally and functionally related to the resp ...	This domain represents the N-terminal of NAD(P)H-quinone oxidoreductase subunit 2 (or subunit B), part of the P-module (pumping) of the photosynthetic complex I from plants and cyanobacteria, which is structurally and functionally related to the respiratory complex I from mitochondria and bacteria. It is involved in the electron transfer between photosynthetic complex I and photosystem I [1].	Domain
E [auth B]	PF00361	Proton-conducting membrane transporter (Proton_antipo_M)	Proton-conducting membrane transporter	-	Family
I [auth H]	PF00346	Respiratory-chain NADH dehydrogenase, 49 Kd subunit (Complex1_49kDa)	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	Family
Q [auth O]	PF11910	Cyanobacterial and plant NDH-1 subunit O (NdhO)	Cyanobacterial and plant NDH-1 subunit O	-	Family
A	PF00146	NADH dehydrogenase (NADHdh)	NADH dehydrogenase	-	Family
J [auth I]	PF12838	4Fe-4S dicluster domain (Fer4_7)	4Fe-4S dicluster domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contai ...	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	Domain
K	PF01058	NADH ubiquinone oxidoreductase, 20 Kd subunit (Oxidored_q6)	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	Family
L	PF10716	NADH dehydrogenase transmembrane subunit (NdhL)	NADH dehydrogenase transmembrane subunit	-	Family
M [auth F]	PF00361	Proton-conducting membrane transporter (Proton_antipo_M)	Proton-conducting membrane transporter	-	Family
M [auth F]	PF00662	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus (Proton_antipo_N)	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	Family
N	PF11909	NADH-quinone oxidoreductase cyanobacterial subunit N (NdhN)	NADH-quinone oxidoreductase cyanobacterial subunit N	-	Family
O [auth M]	PF10664	Cyanobacterial and plastid NDH-1 subunit M (NdhM)	Cyanobacterial and plastid NDH-1 subunit M	-	Family
P [auth S]	PF11623	NAD(P)H dehydrogenase subunit S (NdhS)	NAD(P)H dehydrogenase subunit S	-	Family
B [auth C]	PF00507	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 (Oxidored_q4)	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	Family
C [auth D]	PF00361	Proton-conducting membrane transporter (Proton_antipo_M)	Proton-conducting membrane transporter	-	Family
D [auth E]	PF00420	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L (Oxidored_q2)	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	Family
F [auth G]	PF00499	NADH-ubiquinone/plastoquinone oxidoreductase chain 6 (Oxidored_q3)	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	Family
G [auth J]	PF00329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit (Complex1_30kDa)	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth B]	NAD(P)H-quinone oxidoreductase subunit 2	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
H [auth P]	Proton-translocating NADH-quinone dehydrogenase subunit P NdhP	-	-	-
I [auth H]	NAD(P)H-quinone oxidoreductase subunit H	NAD binding binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity quinone binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
Q [auth O]	NAD(P)H-quinone oxidoreductase subunit O	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	-	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
A	NAD(P)H-quinone oxidoreductase subunit 1	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
J [auth I]	NAD(P)H-quinone oxidoreductase subunit I	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
K	NAD(P)H-quinone oxidoreductase subunit K	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
L	NAD(P)H-quinone oxidoreductase subunit L	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	-	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
M [auth F]	NADH dehydrogenase subunit 5	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy respiratory electron transport chain metabolic process cellular process	membrane cellular anatomical entity
N	NAD(P)H-quinone oxidoreductase subunit N	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	-	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
O [auth M]	NAD(P)H-quinone oxidoreductase subunit M	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	-	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
P [auth S]	Tlr0636 protein	-	photosynthesis photosynthesis, light reaction photosynthetic electron transport chain cellular metabolic process electron transport chain metabolic process cellular process generation of precursor metabolites and energy	-
R [auth Q]	Proton-translocating NADH-quinone dehydrogenase subunit Q NdhQ	-	-	-
B [auth C]	NAD(P)H-quinone oxidoreductase subunit 3	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
C [auth D]	NAD(P)H-quinone oxidoreductase chain 4 1	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy respiratory electron transport chain metabolic process cellular process	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
D [auth E]	NAD(P)H-quinone oxidoreductase subunit 4L	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor catalytic activity binding quinone binding small molecule binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle
F [auth G]	NADH dehydrogenase subunit 6	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	-	cell periphery plasma membrane membrane cellular anatomical entity
G [auth J]	NAD(P)H-quinone oxidoreductase subunit J	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	photosynthesis photosynthesis, light reaction cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid intracellular anatomical structure plasma membrane-derived chromatophore membrane membrane plasma membrane plasma membrane-derived chromatophore cellular anatomical entity thylakoid membrane intracellular organelle cell periphery plasma membrane-derived thylakoid membrane organelle intracellular non-membrane-bounded organelle plasma membrane region bacterial thylakoid cytoplasm photosynthetic membrane thylakoid non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth B]	IPR010096	NAD(P)H-quinone oxidoreductase, subunit N/subunit 2	Family
E [auth B]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit	Domain
E [auth B]	IPR045693	NAD(P)H-quinone oxidoreductase subunit 2, N-terminal	Domain
I [auth H]	IPR022885	NAD(P)H-quinone oxidoreductase subunit D/H	Family
I [auth H]	IPR014029	NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site	Conserved Site
I [auth H]	IPR029014	[NiFe]-hydrogenase, large subunit	Homologous Superfamily
I [auth H]	IPR001135	NADH-quinone oxidoreductase, subunit D	Domain
Q [auth O]	IPR020905	NAD(P)H-quinone oxidoreductase subunit O	Family
A	IPR001694	NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H	Family
A	IPR018086	NADH:ubiquinone oxidoreductase, subunit 1, conserved site	Conserved Site
J [auth I]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
J [auth I]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
J [auth I]	IPR004497	NAD(P)H-quinone oxidoreductase subunit I	Family
J [auth I]	IPR010226	NADH-quinone oxidoreductase, chain I	Family
K	IPR006138	NADH-ubiquinone oxidoreductase, 20 Kd subunit	Family
K	IPR006137	NADH:ubiquinone oxidoreductase-like, 20kDa subunit	Domain
L	IPR019654	NAD(P)H-quinone oxidoreductase subunit L	Family
M [auth F]	IPR003945	NADH-quinone oxidoreductase, chain 5-like	Family
M [auth F]	IPR002128	NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal	Domain
M [auth F]	IPR001516	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal	Domain
M [auth F]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit	Domain
M [auth F]	IPR018393	NADH-plastoquinone oxidoreductase, chain 5 subgroup	Family
N	IPR020874	NAD(P)H-quinone oxidoreductase, subunit N	Family
O [auth M]	IPR018922	NAD(P)H-quinone oxidoreductase subunit M	Family
P [auth S]	IPR021659	NADH dehydrogenase-like complex, subunit S	Family
B [auth C]	IPR023043	NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid	Family
B [auth C]	IPR000440	NADH:ubiquinone/plastoquinone oxidoreductase, chain 3	Family
B [auth C]	IPR038430	NADH:ubiquinone oxidoreductase, subunit 3 superfamily	Homologous Superfamily
C [auth D]	IPR022997	NADH-quinone oxidoreductase chain 4	Family
C [auth D]	IPR003918	NADH:ubiquinone oxidoreductase	Family
C [auth D]	IPR010227	NADH-quinone oxidoreductase, chain M/4	Family
C [auth D]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit	Domain
D [auth E]	IPR001133	NADH-ubiquinone oxidoreductase chain 4L/K	Family
D [auth E]	IPR039428	NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like	Family
F [auth G]	IPR042106	NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ	Homologous Superfamily
F [auth G]	IPR001457	NADH:ubiquinone/plastoquinone oxidoreductase, chain 6	Family
G [auth J]	IPR037232	NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily	Homologous Superfamily
G [auth J]	IPR001268	NADH:ubiquinone oxidoreductase, 30kDa subunit	Domain
G [auth J]	IPR020396	NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site	Conserved Site
G [auth J]	IPR010218	NADH dehydrogenase, subunit C	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth C], C [auth D], D [auth E], E [auth B] A, B [auth C], C [auth D], D [auth E], E [auth B], F [auth G], G [auth J], I [auth H], J [auth I], K, L, M [auth F], N, O [auth M], Q [auth O]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex I (NADH dehydrogenase) and supercomplexes	H+ or Na+ translocating NADH dehydrogenase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth C], C [auth D], D [auth E], E [auth B] A, B [auth C], C [auth D], D [auth E], E [auth B], F [auth G], G [auth J], I [auth H], J [auth I], K, L, M [auth F], N, O [auth M], Q [auth O]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth C], C [auth D], D [auth E], E [auth B] A, B [auth C], C [auth D], D [auth E], E [auth B], F [auth G], G [auth J], I [auth H], J [auth I], K, L, M [auth F], N, O [auth M], Q [auth O]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth C], C [auth D], D [auth E], E [auth B] A, B [auth C], C [auth D], D [auth E], E [auth B], F [auth G], G [auth J], I [auth H], J [auth I], K, L, M [auth F], N, O [auth M], Q [auth O]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Photosystems	Photosynthetic complex I