6HUF

Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6hufa_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth O]	d6hufo_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth N]	d6hufn_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d6hufe_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth C]	d6hufc_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth B]	d6hufb_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth K]	d6hufk_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth M]	d6hufm_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth D]	d6hufd_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth P]	d6hufp_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K [auth F]	d6huff_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L [auth J]	d6hufj_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M [auth G]	d6hufg_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N [auth I]	d6hufi_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O [auth H]	d6hufh_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P [auth L]	d6hufl_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
B [auth O]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
C [auth N]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
F [auth C]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
G [auth K]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
H [auth M]	SCOP2 Family	Ras-like monodomain GTPases	8093771	4004043	SCOP2 (2022-06-29)
H [auth M]	SCOP2 Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2 (2022-06-29)
I [auth D]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
J [auth P]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
K [auth F]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
L [auth J]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
M [auth G]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
N [auth I]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
O [auth H]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)
P [auth L]	SCOP2B Superfamily	Ras-like P-loop GTPases	8093772	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00071	e6hufA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
B [auth O]	PF00071	e6hufO1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
C [auth N]	PF00071	e6hufN1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
E	PF00071	e6hufE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
F [auth C]	PF00071	e6hufC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
D [auth B]	PF00071	e6hufB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
G [auth K]	PF00071	e6hufK1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
H [auth M]	PF00071	e6hufM1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
I [auth D]	PF00071	e6hufD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
J [auth P]	PF00071	e6hufP1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
K [auth F]	PF00071	e6hufF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
L [auth J]	PF00071	e6hufJ1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
M [auth G]	PF00071	e6hufG1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
N [auth I]	PF00071	e6hufI1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
O [auth H]	PF00071	e6hufH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)
P [auth L]	PF00071	e6hufL1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00071	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B [auth O]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
C [auth N]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
F [auth C]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
D [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
G [auth K]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
H [auth M]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
I [auth D]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
J [auth P]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
K [auth F]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
L [auth J]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
M [auth G]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
N [auth I]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
O [auth H]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
P [auth L]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	Ras-related protein Rab-27A	protein binding binding protein domain specific binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding protein binding binding protein domain specific binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GDP binding cytoskeletal protein binding myosin V binding myosin binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	vesicle organization cellular component organization organelle organization multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation vesicle organization cellular component organization organelle organization multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of localization regulated exocytosis regulation of cellular process transport positive regulation of biological process positive regulation of secretion by cell vesicle-mediated transport positive regulation of exocytosis regulation of regulated secretory pathway localization secretion by cell regulation of secretion by cell positive regulation of secretion positive regulation of regulated secretory pathway positive regulation of cellular process regulation of biological process secretion regulation of transport export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion exocytosis positive regulation of transport regulation of exocytosis cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental process pigment cell differentiation pigmentation cellular developmental process cell differentiation developmental pigmentation melanocyte differentiation vesicle localization establishment of organelle localization cellular localization establishment of vesicle localization organelle localization establishment of localization in cell synaptic vesicle localization synaptic vesicle transport import into cell positive regulation of cellular component organization regulation of cellular component organization positive regulation of endocytosis phagocytosis regulation of endocytosis regulation of phagocytosis positive regulation of phagocytosis endocytosis lymphocyte mediated immunity biological process involved in interspecies interaction between organisms lymphocyte activation cell activation involved in immune response leukocyte degranulation response to biotic stimulus leukocyte activation natural killer cell activation involved in immune response leukocyte activation involved in immune response innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity lymphocyte activation involved in immune response immune response response to other organism defense response cell activation defense response to symbiont response to external stimulus natural killer cell activation leukocyte mediated cytotoxicity immune effector process immune system process defense response to other organism natural killer cell degranulation natural killer cell mediated cytotoxicity cell killing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity T cell activation involved in immune response T cell activation cytotoxic T cell degranulation T cell mediated cytotoxicity adaptive immune response positive regulation of constitutive secretory pathway regulation of constitutive secretory pathway constitutive secretory pathway multivesicular body sorting pathway pigment granule localization cellular pigmentation melanosome localization establishment of melanosome localization pigment granule transport establishment of pigment granule localization melanosome transport reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process complement-dependent cytotoxicity antigen processing and presentation exosomal secretion extracellular exosome biogenesis cellular component biogenesis extracellular vesicle biogenesis	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane endosome membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane endosome membrane multivesicular body membrane late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane late endosome organelle membrane multivesicular body cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol Weibel-Palade body secretory granule clathrin-coated vesicle secretory vesicle coated vesicle transport vesicle exocytic vesicle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection lytic vacuole vacuole lysosome non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium Golgi apparatus vesicle lumen membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular organelle lumen organelle lumen specific granule lumen specific granule chitosome melanosome membrane pigment granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	IPR041837	Rab27a/b	Family
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	IPR001806	Small GTPase	Family
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	IPR005225	Small GTP-binding protein domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth O], C [auth N], D [auth B], E, A, B [auth O], C [auth N], D [auth B], E, F [auth C], G [auth K], H [auth M], I [auth D], J [auth P], K [auth F], L [auth J], M [auth G], N [auth I], O [auth H], P [auth L]	Pharos: P51159	Griscelli syndrome type 2 Griscelli syndrome malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer adenoma subependymal giant cell astrocytoma Crohn disease gastric carcinoma intellectual disability large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Griscelli syndrome type 2 Griscelli syndrome malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer adenoma subependymal giant cell astrocytoma Crohn disease gastric carcinoma intellectual disability large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis atypical teratoid rhabdoid tumor ulcerative colitis cutaneous lupus erythematosus glioblastoma hemophagocytic syndrome interstitial cystitis lung cancer malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Sjogren syndrome Chediak-Higashi syndrome ductal breast carcinoma in situ IgA glomerulonephritis invasive ductal breast carcinoma malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.