Annotations: 6HQA

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Taf5 N-terminal domain-like	8080640	3001495	SCOP2B (2022-06-29)
C	SCOP2 Family	Taf5 N-terminal domain-like	8080639	4002620	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Taf5 N-terminal domain-like	8080640	3001495	SCOP2 (2022-06-29)
J [auth K]	SCOP2 Family	TBP-associated factors TAFs	8085124	4000797	SCOP2 (2022-06-29)
J [auth K]	SCOP2 Superfamily	Core histone-like	8085125	3001387	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17900	e6hqaA3	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: PF17900	ECOD (1.6)
A	F_UNCLASSIFIED	e6hqaA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e6hqaA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF04494	e6hqaC1	A: alpha superhelices	X: Taf5 N-terminal domain-like (From Topology)	H: Taf5 N-terminal domain-like (From Topology)	T: Taf5 N-terminal domain-like	F: PF04494	ECOD (1.6)
F	PF02291	e6hqaF1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: PF02291	ECOD (1.6)
J [auth K]	PF03847	e6hqaK1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: PF03847	ECOD (1.6)
K [auth J]	F_UNCLASSIFIED	e6hqaJ1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, C	PF04494	WD40 associated region in TFIID subunit, NTD2 domain (TFIID_NTD2)	WD40 associated region in TFIID subunit, NTD2 domain	-	Family
B, C	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
D, E	PF07571	TAF6 C-terminal HEAT repeat domain (TAF6_C)	TAF6 C-terminal HEAT repeat domain	-	Repeat
D, E	PF02969	TATA box binding protein associated factor (TAF) (TAF)	TATA box binding protein associated factor (TAF)	TAF proteins adopt a histone-like fold.	Domain
F	PF02291	Transcription initiation factor IID, 31kD subunit (TFIID-31kDa)	Transcription initiation factor IID, 31kD subunit	This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.	Domain
J [auth K]	PF03847	Transcription initiation factor TFIID subunit A (TFIID_20kDa)	Transcription initiation factor TFIID subunit A	-	Domain
K [auth J]	PF05236	Transcription initiation factor TFIID component TAF4 family (TAF4)	Transcription initiation factor TFIID component TAF4 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Taf2	-	-	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
B, C	Subunit (90 kDa) of TFIID and SAGA complexes	-	regulation of biological process biological regulation metabolic process primary metabolic process regulation of metabolic process regulation of primary metabolic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of cellular biosynthetic process biosynthetic process cellular process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity
D, E	Subunit (60 kDa) of TFIID and SAGA complexes	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding protein-containing complex binding chromatin binding protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity molecular adaptor activity identical protein binding	cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly organic substance metabolic process transcription by RNA polymerase II protein-containing complex assembly organic substance biosynthetic process cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly organic substance metabolic process transcription by RNA polymerase II protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization cellular metabolic process protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II chromatin organization	protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex intracellular organelle lumen nucleoplasm intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex nuclear lumen SLIK (SAGA-like) complex
F	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation	protein-containing complex binding chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity molecular adaptor activity identical protein binding	cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly organic substance metabolic process transcription by RNA polymerase II protein-containing complex assembly organic substance biosynthetic process cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly organic substance metabolic process transcription by RNA polymerase II protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization cellular metabolic process protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process chromatin organization	protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex intracellular organelle lumen nucleoplasm intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex nuclear lumen SLIK (SAGA-like) complex
G	Taf8	-	-	-
H [auth I]	Histone-fold	-	-	-
I [auth H]	Histone-fold	-	-	-
J [auth K]	Subunit (61/68 kDa) of TFIID and SAGA complexes	protein heterodimerization activity protein binding binding protein dimerization activity	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process	protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex cellular anatomical entity histone acetyltransferase complex acetyltransferase complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex intracellular organelle lumen nucleoplasm intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex nuclear lumen SLIK (SAGA-like) complex
K [auth J]	TFIID subunit (48 kDa)	-	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
A	IPR037813	Transcription initiation factor TFIID subunit 2	Family
A	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
B, C	IPR001680	WD40 repeat	Repeat
B, C	IPR007582	TFIID subunit TAF5, NTD2 domain	Domain
B, C	IPR019775	WD40 repeat, conserved site	Conserved Site
B, C	IPR020472	G-protein beta WD-40 repeat	Repeat
B, C	IPR037264	TFIID subunit TAF5, NTD2 domain superfamily	Homologous Superfamily
B, C	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B, C	IPR006594	LIS1 homology motif	Conserved Site
B, C	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D, E	IPR009072	Histone-fold	Homologous Superfamily
D, E	IPR011442	TAF6, C-terminal HEAT repeat domain	Domain
D, E	IPR037796	Transcription initiation factor TFIID subunit 6	Family
D, E	IPR016024	Armadillo-type fold	Homologous Superfamily
D, E	IPR046344	TAF6, C-terminal HEAT repeat domain superfamily	Homologous Superfamily
D, E	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
F	IPR009072	Histone-fold	Homologous Superfamily
F	IPR003162	Transcription initiation factor TAFII31	Family
J [auth K]	IPR009072	Histone-fold	Homologous Superfamily
J [auth K]	IPR037794	Transcription initiation factor TFIID subunit 12	Family
J [auth K]	IPR003228	Transcription initiation factor TFIID subunit 12 domain	Domain
K [auth J]	IPR045144	Transcription initiation factor TFIID component TAF4	Family
K [auth J]	IPR007900	Transcription initiation factor TFIID component TAF4, C-terminal	Domain