Annotations: 6HPB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07927	e6hpbA1	A: a+b two layers	X: dsRBD-like	H: PI-Pfui intein middle domain (From Topology)	T: PI-Pfui intein middle domain	F: PF07927	ECOD (1.6)
C	PF07927	e6hpbC1	A: a+b two layers	X: dsRBD-like	H: PI-Pfui intein middle domain (From Topology)	T: PI-Pfui intein middle domain	F: PF07927	ECOD (1.6)
B	PF01381	e6hpbB2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
B	PF15919	e6hpbB1	A: a+b duplicates or obligate multimers	X: TTHA1013/TTHA0281-like (From Topology)	H: TTHA1013/TTHA0281-like (From Topology)	T: TTHA1013/TTHA0281-like	F: PF15919	ECOD (1.6)
D	PF01381	e6hpbD2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF01381	ECOD (1.6)
D	PF15919	e6hpbD1	A: a+b duplicates or obligate multimers	X: TTHA1013/TTHA0281-like (From Topology)	H: TTHA1013/TTHA0281-like (From Topology)	T: TTHA1013/TTHA0281-like	F: PF15919	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF07927	HicA toxin of bacterial toxin-antitoxin, (HicA_toxin)	HicA toxin of bacterial toxin-antitoxin,	-	Family
B, D	PF01381	Helix-turn-helix (HTH_3)	Helix-turn-helix	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be ...	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	Domain
B, D	PF15919	HicB_like antitoxin of bacterial toxin-antitoxin system (HicB_lk_antitox)	HicB_like antitoxin of bacterial toxin-antitoxin system	This is a family of HicB-like antitoxins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	mRNA interferase toxin HicA	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process catabolic process negative regulation of biological process negative regulation of cellular metabolic process macromolecule catabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process mRNA catabolic process negative regulation of metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process organic substance catabolic process	protein-containing complex transcription regulator complex toxin-antitoxin complex transcription repressor complex
B, D	Antitoxin HicB	DNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	protein-containing complex transcription regulator complex toxin-antitoxin complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR012933	HicA mRNA interferase family	Family
A, C	IPR038570	HicA superfamily	Homologous Superfamily
B, D	IPR035069	TTHA1013/TTHA0281-like	Homologous Superfamily
B, D	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
B, D	IPR031807	HicB-like antitoxin of toxin-antitoxin system	Domain
B, D	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.