Annotations: 6HIN

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
A, B, C, D, E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	5-hydroxytryptamine receptor 3A	cation binding binding ion binding serotonin binding organic cyclic compound binding amine binding heterocyclic compound binding small molecule binding ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential monoatomic ion channel activity cation binding binding ion binding serotonin binding organic cyclic compound binding amine binding heterocyclic compound binding small molecule binding ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity serotonin-gated monoatomic cation channel activity signaling receptor activity neurotransmitter receptor activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity serotonin receptor activity transmembrane signaling receptor activity transmitter-gated channel activity ligand-gated monoatomic cation channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity acetylcholine-gated monoatomic cation-selective channel activity excitatory extracellular ligand-gated monoatomic ion channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential identical protein binding protein binding	transmembrane transport localization transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport cellular response to stimulus cellular response to nitrogen compound response to dopamine response to organic substance regulation of cellular process response to stimulus signaling transmembrane transport localization transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport cellular response to stimulus cellular response to nitrogen compound response to dopamine response to organic substance regulation of cellular process response to stimulus signaling cellular response to dopamine response to monoamine cell communication cellular response to endogenous stimulus response to catecholamine cellular response to catecholamine stimulus cellular response to organic substance signal transduction response to organic cyclic compound regulation of biological process response to organonitrogen compound response to endogenous stimulus serotonin receptor signaling pathway cellular response to organic cyclic compound biological regulation response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to monoamine stimulus response to chemical	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane presynapse presynaptic membrane cell division site cleavage furrow cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane presynapse presynaptic membrane cell division site cleavage furrow glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body axon protein-containing complex serotonin-activated cation-selective channel complex plasma membrane protein complex membrane protein complex cation channel complex transporter complex receptor complex neurotransmitter receptor complex transmembrane transporter complex plasma membrane signaling receptor complex serotonin receptor complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B, C, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B, C, D, E	IPR008133	5-hydroxytryptamine 3 receptor, A subunit	Family
A, B, C, D, E	IPR008132	5-hydroxytryptamine 3 receptor	Family
A, B, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E	OPM	Transmembrane	Alpha-helical polytopic	Pentameric ligand-gated ion channels	Ligand-gated ion channel of neurotransmitter receptors

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Cys-Loop Receptor Family	Serotonin 5-HT_3A receptor with bound serotonin, F conformation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.