Annotations: 6HE4

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	PF17862	e6he4H2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
A [auth H]	PF00004	e6he4H1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
B [auth I]	PF17862	e6he4I1	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
B [auth I]	PF00004	e6he4I2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
C [auth K]	PF17862	e6he4K2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
C [auth K]	PF00004	e6he4K1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
D [auth L]	PF17862	e6he4L2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
D [auth L]	PF00004	e6he4L1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
E [auth M]	PF17862	e6he4M2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
E [auth M]	PF00004	e6he4M1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
F [auth J]	PF17862	e6he4J2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17862	ECOD (1.6)
F [auth J]	PF00004	e6he4J1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	Proteasome-activating nucleotidase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	cellular process protein unfolding organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process cellular process protein unfolding organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome-activating nucleotidase complex cellular anatomical entity intracellular protein-containing complex cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR032501	Proteasomal ATPase, second OB domain	Domain
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR003593	AAA+ ATPase domain	Domain
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR003959	ATPase, AAA-type, core	Domain
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR023501	Proteasome-activating nucleotidase PAN	Family
A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], A [auth H], B [auth I], C [auth K], D [auth L], E [auth M], F [auth J]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.