Annotations: 6HCY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF01794	e6hcyC2	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: PF01794	ECOD (1.6)
A [auth C]	PF03807	e6hcyC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF03807	ECOD (1.6)
B [auth A]	PF01794	e6hcyA1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: PF01794	ECOD (1.6)
B [auth A]	PF03807	e6hcyA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF03807	ECOD (1.6)
C [auth B]	PF01794	e6hcyB1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: PF01794	ECOD (1.6)
C [auth B]	PF03807	e6hcyB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF03807	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B]	PF03807	NADP oxidoreductase coenzyme F420-dependent (F420_oxidored)	NADP oxidoreductase coenzyme F420-dependent	-	Family
A [auth C], B [auth A], C [auth B]	PF01794	Ferric reductase like transmembrane component (Ferric_reduct)	Ferric reductase like transmembrane component	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B]	Metalloreductase STEAP4	oxidoreductase activity, acting on metal ions oxidoreductase activity oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor catalytic activity cupric reductase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding oxidoreductase activity, acting on metal ions oxidoreductase activity oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor catalytic activity cupric reductase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding tetrapyrrole binding heme binding ferric-chelate reductase (NADPH) activity ferric-chelate reductase activity electron transfer activity cation binding metal ion binding	localization transport copper ion import copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport developmental process fat cell differentiation cellular developmental process cell differentiation cellular process localization transport copper ion import copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport developmental process fat cell differentiation cellular developmental process cell differentiation cellular process protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis cellular localization inorganic ion homeostasis iron import into cell homeostatic process iron ion transport intracellular iron ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis establishment of localization in cell monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle Golgi membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle Golgi membrane Golgi apparatus bounding membrane of organelle organelle membrane endosome membrane early endosome early endosome membrane cytoplasmic vesicle membrane vesicle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B]	IPR013130	Ferric reductase transmembrane component-like domain	Domain
A [auth C], B [auth A], C [auth B]	IPR028939	Pyrroline-5-carboxylate reductase, catalytic, N-terminal	Domain
A [auth C], B [auth A], C [auth B]	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth A], C [auth B]	Pharos: Q687X5	Liver Cirrhosis, Experimental prostate cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer psoriasis ulcerative colitis adrenal cortex adenoma breast carcinoma exocrine pancreatic carcinoma hepatocellular carcinoma malignant pancreatic neoplasm nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Liver Cirrhosis, Experimental prostate cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer psoriasis ulcerative colitis adrenal cortex adenoma breast carcinoma exocrine pancreatic carcinoma hepatocellular carcinoma malignant pancreatic neoplasm nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida adrenal cortex carcinoma diabetes mellitus gastric cancer interstitial cystitis lung cancer MALT lymphoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma tuberculosis breast cancer ductal breast carcinoma in situ gastric carcinoma invasive ductal breast carcinoma lung carcinoma medulloblastoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B [auth A], C [auth B]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex II superfamily	Transmembrane ferric reductase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth A], C [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth C], B [auth A], C [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth C], B [auth A], C [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Oxidoreductases	STEAP4 (STEAP=Six-TM epithelial antigen of the prostate) bound to NADP, FAD, heme and Fe(III)-NTA

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.