Annotations: 6H3C

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I [auth E]	SCOP2B Superfamily	PLP-dependent transferases	8036728	3000954	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PLP-dependent transferases	8036728	3000954	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6h3cA1	A: alpha bundles	X: BRCC36 C-terminal helical domain (From Topology)	H: BRCC36 C-terminal helical domain (From Topology)	T: BRCC36 C-terminal helical domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF21125	e6h3cA2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF21125	ECOD (1.6)
E [auth F]	F_UNCLASSIFIED	e6h3cF2	A: alpha bundles	X: BRCC36 C-terminal helical domain (From Topology)	H: BRCC36 C-terminal helical domain (From Topology)	T: BRCC36 C-terminal helical domain	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth F]	PF21125	e6h3cF1	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF21125	ECOD (1.6)
B	PF18110	e6h3cB1	A: alpha bundles	X: BRCC36 C-terminal helical domain (From Topology)	H: BRCC36 C-terminal helical domain (From Topology)	T: BRCC36 C-terminal helical domain	F: PF18110	ECOD (1.6)
B	PF01398	e6h3cB2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
F [auth G]	PF18110	e6h3cG1	A: alpha bundles	X: BRCC36 C-terminal helical domain (From Topology)	H: BRCC36 C-terminal helical domain (From Topology)	T: BRCC36 C-terminal helical domain	F: PF18110	ECOD (1.6)
F [auth G]	PF01398	e6h3cG2	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398	ECOD (1.6)
C	PF06113	e6h3cC1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF06113	ECOD (1.6)
G [auth H]	PF06113	e6h3cH1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF06113	ECOD (1.6)
D	F_UNCLASSIFIED	e6h3cD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth I]	F_UNCLASSIFIED	e6h3cI1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth E]	PF00464	e6h3cE2	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: PF00464	ECOD (1.6)
I [auth E]	PF00464	e6h3cE1	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: PF00464	ECOD (1.6)
J	PF00464	e6h3cJ2	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: PF00464	ECOD (1.6)
J	PF00464	e6h3cJ1	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: PF00464	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth F]	PF21125	BRCA1-A complex subunit Abraxas 1 MPN domain (MPN_2A_DUB_like)	BRCA1-A complex subunit Abraxas 1 MPN domain	This entry represents the MPN domain from the Abraxas protein [1-3]. Abraxas is a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substra ...	This entry represents the MPN domain from the Abraxas protein [1-3]. Abraxas is a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates.	Domain
B, F [auth G]	PF18110	BRCC36 C-terminal helical domain (BRCC36_C)	BRCC36 C-terminal helical domain	This is the C-terminal domain of BRCC36, a Zn2+ dependent deubiquitinating enzyme, present in Camponotus floridanus. BRCC36 hydrolyzes lysine linked ubiquitin chains as part of macromolecular complexes that participate in either interferon signalling ...	This is the C-terminal domain of BRCC36, a Zn2+ dependent deubiquitinating enzyme, present in Camponotus floridanus. BRCC36 hydrolyzes lysine linked ubiquitin chains as part of macromolecular complexes that participate in either interferon signalling or DNA-damage recognition. The domain consists of 2 non canonical helices. The domain interacts hydrophobically with helices alpha 4 and alpha 5 of KIAA0157 in the form of a coiled coil helical bundle. This interaction helps establish the association of BRCC36 with KIAA0157, a pseudo-DUB MPN- protein that is essential for the activity of BRCC36 [1].	Domain
B, F [auth G]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
C, G [auth H]	PF06113	Brain and reproductive organ-expressed protein (BRE) (BRE)	Brain and reproductive organ-expressed protein (BRE)	-	Family
I [auth E], J	PF00464	Serine hydroxymethyltransferase (SHMT)	Serine hydroxymethyltransferase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth F]	BRISC complex subunit Abraxas 2	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding polyubiquitin modification-dependent protein binding modification-dependent protein binding	cellular process cell cycle mitotic cell cycle establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization cellular process cell cycle mitotic cell cycle establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization chromosome segregation cell cycle process cell division response to stimulus response to stress response to ischemia non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis spindle organization mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process microtubule-based process cytoskeleton organization protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex BRISC complex nucleus intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex BRISC complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm cytosol polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
B, F [auth G]	Lys-63-specific deubiquitinase BRCC36	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity enzyme regulator activity molecular function regulator activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity cysteine-type peptidase activity cysteine-type deubiquitinase activity polyubiquitin modification-dependent protein binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity enzyme regulator activity molecular function regulator activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity cysteine-type peptidase activity cysteine-type deubiquitinase activity polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding cation binding ion binding metal ion binding small molecule binding	cellular process cell division cellular response to stimulus DNA repair-dependent chromatin remodeling response to stimulus protein-containing complex organization protein-DNA complex organization cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular component organization or biogenesis cellular process cell division cellular response to stimulus DNA repair-dependent chromatin remodeling response to stimulus protein-containing complex organization protein-DNA complex organization cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular component organization or biogenesis response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus cellular response to ionizing radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus regulation of cellular process positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair organic substance metabolic process regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair organic cyclic compound metabolic process positive regulation of DNA metabolic process regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination protein modification by small protein removal macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint regulation of intracellular signal transduction negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular component organization positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response protein-containing complex assembly response to external biotic stimulus positive regulation of innate immune response defense response positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis immune system process positive regulation of signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition double-strand break repair proteolysis	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex nuclear protein-containing complex BRCA1-A complex BRISC complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex nuclear ubiquitin ligase complex
C, G [auth H]	BRISC and BRCA1-A complex member 2	signal sequence binding binding peroxisome targeting sequence binding peptide binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell division regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell division regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair organic substance metabolic process regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair organic cyclic compound metabolic process positive regulation of DNA metabolic process regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process protein deubiquitination organonitrogen compound metabolic process protein K63-linked deubiquitination protein modification by small protein removal macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint regulation of intracellular signal transduction negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition double-strand break repair protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex nuclear protein-containing complex BRCA1-A complex BRISC complex ubiquitin ligase complex catalytic complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex
D, H [auth I]	BRISC and BRCA1-A complex member 1	-	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process response to ionizing radiation response to stimulus response to radiation response to abiotic stimulus developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process response to ionizing radiation response to stimulus response to radiation response to abiotic stimulus cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition DNA damage checkpoint signaling signaling G2/M transition of mitotic cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process DNA damage response negative regulation of cell cycle G2/M phase transition signal transduction in response to DNA damage negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition cell division DNA repair-dependent chromatin remodeling protein-containing complex organization protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis double-strand break repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair regulation of cellular response to stress regulation of primary metabolic process regulation of response to stress regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process regulation of DNA repair regulation of response to stimulus regulation of metabolic process regulation of DNA metabolic process positive regulation of biological process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure BRISC complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure BRISC complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen BRCA1-A complex
I [auth E], J	Serine hydroxymethyltransferase, mitochondrial	vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding cation binding organic acid binding serine binding amino acid binding carboxylic acid binding vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding cation binding organic acid binding serine binding amino acid binding carboxylic acid binding protein-containing complex binding chromatin binding translation regulator activity mRNA regulatory element binding translation repressor activity translation regulator activity, nucleic acid binding nucleic acid binding translation repressor activity threonine aldolase activity L-allo-threonine aldolase activity lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity transferase activity, transferring one-carbon groups glycine hydroxymethyltransferase activity transferase activity hydroxymethyl-, formyl- and related transferase activity RNA binding mRNA 5'-UTR binding mRNA binding transition metal ion binding zinc ion binding metal ion binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein homotetramerization protein homooligomerization organonitrogen compound metabolic process nucleobase biosynthetic process purine nucleobase metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein homotetramerization protein homooligomerization organonitrogen compound metabolic process nucleobase biosynthetic process purine nucleobase metabolic process organonitrogen compound biosynthetic process purine nucleobase biosynthetic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process nucleobase metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular metabolic process cellular modified amino acid metabolic process folic acid-containing compound metabolic process tetrahydrofolate interconversion tetrahydrofolate metabolic process pteridine-containing compound metabolic process one-carbon metabolic process catabolic process serine family amino acid metabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process L-serine catabolic process alpha-amino acid metabolic process cellular catabolic process carboxylic acid catabolic process amino acid catabolic process organonitrogen compound catabolic process carboxylic acid metabolic process L-amino acid catabolic process L-serine metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process serine family amino acid catabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process small molecule catabolic process organic substance catabolic process protein deubiquitination protein K63-linked deubiquitination protein modification by small protein removal macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal cellular biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process L-serine biosynthetic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process serine family amino acid biosynthetic process alpha-amino acid biosynthetic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process mitochondrial translation regulation of mitochondrial gene expression mitochondrial gene expression regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of biosynthetic process regulation of protein metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression regulation of mitochondrial translation regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process response to organic substance biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to chemical immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus response to type I interferon aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration regulation of aerobic respiration regulation of oxidative phosphorylation glycine metabolic process dicarboxylic acid metabolic process vitamin metabolic process amide metabolic process water-soluble vitamin metabolic process folic acid metabolic process glycine biosynthetic process glycine biosynthetic process from serine	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex BRISC complex nucleus nuclear protein-containing complex membrane-enclosed lumen nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen mitochondrial nucleoid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth F]	IPR023238	FAM175 family	Family
A, E [auth F]	IPR037518	MPN domain	Domain
A, E [auth F]	IPR023240	BRISC complex, Abraxas 2 subunit	Family
B, F [auth G]	IPR033860	Brcc36 isopeptidase	Family
B, F [auth G]	IPR037518	MPN domain	Domain
B, F [auth G]	IPR040749	BRCC36, C-terminal helical domain	Domain
B, F [auth G]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
C, G [auth H]	IPR010358	BRCA1-A complex subunit BRE	Family
D, H [auth I]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
D, H [auth I]	IPR026126	BRISC and BRCA1-A complex member 1	Family
I [auth E], J	IPR019798	Serine hydroxymethyltransferase, pyridoxal phosphate binding site	Binding Site
I [auth E], J	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
I [auth E], J	IPR015422	Pyridoxal phosphate-dependent transferase, small domain	Homologous Superfamily
I [auth E], J	IPR039429	Serine hydroxymethyltransferase-like domain	Domain
I [auth E], J	IPR001085	Serine hydroxymethyltransferase	Family
I [auth E], J	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E [auth F]	Pharos: Q15018	inflammatory bowel disease psoriasis
B, F [auth G]	Pharos: P46736	moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome cancer rheumatoid arthritis cerebrovascular disorder pancreatic intraductal papillary-mucinous carcinoma vascular disease Crohn disease pancreatic intraductal papillary-mucinous neoplasm
C, G [auth H]	Pharos: Q9NXR7	adrenal cortex carcinoma Crohn disease ovarian cancer allergic rhinitis inflammatory bowel disease tuberculosis bipolar I disorder osteosarcoma
D, H [auth I]	Pharos: Q9NWV8	ovarian cancer breast carcinoma lung cancer ovarian carcinoma rheumatoid arthritis estrogen-receptor negative breast cancer Malignant neoplasm of ovary ovarian neoplasm triple-negative breast carcinoma large cell medulloblastoma plasma cell myeloma
I [auth E], J	Pharos: P34897	non-small cell lung carcinoma nasopharyngeal carcinoma osteosarcoma plasma cell myeloma Sjogren syndrome abdominal aortic aneurysm astrocytic tumor breast cancer colorectal cancer heart disease lung cancer malignant glioma ovarian cancer Plasmodium vivax malaria acute myeloid leukemia non-small cell lung carcinoma nasopharyngeal carcinoma osteosarcoma plasma cell myeloma Sjogren syndrome abdominal aortic aneurysm astrocytic tumor breast cancer colorectal cancer heart disease lung cancer malignant glioma ovarian cancer Plasmodium vivax malaria acute myeloid leukemia atopic eczema cardiomyopathy diabetes mellitus large cell medulloblastoma malignant colon neoplasm medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma psoriasis adrenal cortex carcinoma autism spectrum disorder colorectal adenoma glioblastoma lung adenocarcinoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.