Annotations: 6H3A

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	B-box zinc-binding domain	8089238	3001359	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	B-box zinc-binding domain	8089238	3001359	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	F_UNCLASSIFIED	e6h3aD1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth B]	F_UNCLASSIFIED	e6h3aB1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth A]	PF14634	e6h3aA2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF14634	ECOD (1.6)
B [auth A]	PF00643	e6h3aA1	A: few secondary structure elements	X: B-box zinc-binding domain-like	H: B-box zinc-binding domain (From Topology)	T: B-box zinc-binding domain	F: PF00643	ECOD (1.6)
D [auth F]	PF14634	e6h3aF1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF14634	ECOD (1.6)
D [auth F]	PF00643	e6h3aF2	A: few secondary structure elements	X: B-box zinc-binding domain-like	H: B-box zinc-binding domain (From Topology)	T: B-box zinc-binding domain	F: PF00643	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], D [auth F]	PF14634	zinc-RING finger domain (zf-RING_5)	zinc-RING finger domain	-	Domain
B [auth A], D [auth F]	PF00643	B-box zinc finger (zf-B_box)	B-box zinc finger	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], C [auth B]	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ATP-dependent activity, acting on DNA catalytic activity, acting on DNA protein binding ubiquitin binding ubiquitin-like protein binding ATP-dependent chromatin remodeler activity	cellular response to stimulus double-strand break repair response to stimulus DNA double-strand break processing primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA double-strand break processing primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair chromosome separation cell cycle chromosome segregation cell cycle process regulation of DNA recombination regulation of biological process DNA recombination biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization chromatin remodeling cellular component organization or biogenesis	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen nuclear replication fork nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen replication fork nuclear lumen site of double-strand break site of DNA damage nucleoplasm
B [auth A], D [auth F]	Transcription intermediary factor 1-beta	Krueppel-associated box domain binding protein binding binding protein domain specific binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity chromo shadow domain binding Krueppel-associated box domain binding protein binding binding protein domain specific binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity chromo shadow domain binding protein-containing complex binding chromatin binding promoter-specific chromatin binding SUMO transferase activity DNA binding organic cyclic compound binding nucleic acid binding kinase activity protein kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding transcription corepressor activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus organonitrogen compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus organonitrogen compound metabolic process peptidyl-lysine modification primary metabolic process organic substance metabolic process protein sumoylation macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal developmental process axis elongation epithelium development developmental growth growth morphogenesis of an epithelium tissue development developmental growth involved in morphogenesis anatomical structure morphogenesis tissue morphogenesis convergent extension involved in axis elongation convergent extension anatomical structure development cellular response to stimulus regulation of cellular process positive regulation of biological process regulation of cellular response to stress regulation of primary metabolic process positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of DNA repair cellular response to stress regulation of response to stress positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair organic cyclic compound metabolic process positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response cellular process regulation of metabolic process regulation of DNA metabolic process protein localization regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle cellular developmental process cell differentiation animal organ development mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition positive regulation of organelle organization negative regulation of biological process negative regulation of cellular metabolic process cellular component biogenesis chromatin organization organic substance biosynthetic process regulation of heterochromatin formation regulation of chromatin organization regulation of DNA methylation-dependent heterochromatin formation cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of chromosome organization regulation of organelle organization negative regulation of cellular biosynthetic process positive regulation of chromosome organization regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA methylation-dependent heterochromatin formation cellular component organization protein-DNA complex organization positive regulation of heterochromatin formation negative regulation of cellular process DNA methylation-dependent heterochromatin formation positive regulation of chromatin organization chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization positive regulation of cellular component biogenesis epigenetic regulation of gene expression chromosome organization gene expression regulation of cellular component biogenesis macromolecule biosynthetic process regulation of cellular biosynthetic process organelle organization negative regulation of biosynthetic process facultative heterochromatin formation negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process defense response to virus suppression of viral release by host response to virus multicellular organism development multicellular organismal process multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process epigenetic programming of gene expression positive regulation of macromolecule biosynthetic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process placenta development chordate embryonic development embryonic morphogenesis embryo development in utero embryonic development embryonic placenta morphogenesis embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development viral life cycle single stranded viral RNA replication via double stranded DNA intermediate viral genome replication regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of viral process viral RNA genome replication viral process negative regulation of viral genome replication regulation of viral process regulation of viral life cycle regulation of viral genome replication sexual reproduction cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation multicellular organismal reproductive process genomic imprinting germ cell development DNA modification regulation of DNA demethylation DNA demethylation negative regulation of DNA demethylation DNA dealkylation negative regulation of DNA metabolic process demethylation	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen euchromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], C [auth B]	IPR000330	SNF2, N-terminal	Domain
A [auth D], C [auth B]	IPR001650	Helicase, C-terminal domain-like	Domain
A [auth D], C [auth B]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A [auth D], C [auth B]	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
A [auth D], C [auth B]	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
A [auth D], C [auth B]	IPR003892	Ubiquitin system component CUE	Domain
A [auth D], C [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth A], D [auth F]	IPR001965	Zinc finger, PHD-type	Domain
B [auth A], D [auth F]	IPR047058	Transcription intermediary factor 1-beta, B-box-type 2 zinc finger	Domain
B [auth A], D [auth F]	IPR042713	TIF1-beta, RING finger, HC subclass	Domain
B [auth A], D [auth F]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B [auth A], D [auth F]	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
B [auth A], D [auth F]	IPR003649	B-box, C-terminal	Domain
B [auth A], D [auth F]	IPR001841	Zinc finger, RING-type	Domain
B [auth A], D [auth F]	IPR001487	Bromodomain	Domain
B [auth A], D [auth F]	IPR037373	Transcription intermediary factor 1-beta, PHD domain	Domain
B [auth A], D [auth F]	IPR019787	Zinc finger, PHD-finger	Domain
B [auth A], D [auth F]	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
B [auth A], D [auth F]	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
B [auth A], D [auth F]	IPR047059	Transcription intermediary factor 1-beta, B-box-type 1 zinc finger	Domain
B [auth A], D [auth F]	IPR000315	B-box-type zinc finger	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth D], C [auth B]	Pharos: Q9H4L7	isolated congenital adermatoglyphia absence of fingerprints-congenital milia syndrome palmoplantar keratosis prostate cancer erythrokeratoderma large cell medulloblastoma primitive neuroectodermal tumor testicular cancer acute myeloid leukemia Fingerprints, Absence of medulloblastoma pancreatic ductal adenocarcinoma testicular germ cell tumor palmoplantar keratoderma-sclerodactyly syndrome Pick disease
B [auth A], D [auth F]	Pharos: Q13263	colorectal cancer colorectal adenoma primary hyperoxaluria type 1 diabetes mellitus