Annotations: 6H2Y

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth H]	d6h2yh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth L]	d6h2yl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth L]	d6h2yl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	Lipoprot_C_1st	e6h2yD2	A: beta barrels	X: Outer membrane meander beta-barrels	H: OMPA-like (From Topology)	T: OMPA-like	F: Lipoprot_C_1st	ECOD (1.6)
A [auth D]	Lipoprot_C_2nd	e6h2yD1	A: beta barrels	X: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	H: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	T: Factor H-binding protein (fHbp) N-terminal beta-barrel domain	F: Lipoprot_C_2nd	ECOD (1.6)
B [auth H]	V-set_8	e6h2yH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B [auth H]	C1-set_1	e6h2yH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C [auth L]	C1-set	e6h2yL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
C [auth L]	V-set_3	e6h2yL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	2.60.40.1980	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (utative)
A [auth D]	2.40.160.90	Mainly Beta	Beta Barrel	Porin		CATH (utative)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth H]	Fab 1E6	VH-CH1	Homo sapiens (human)	IGHV1-6906, IGHV1-6914, IGHJ401, IGHJ402, IGHJ403, IGHG103, IGHG108, IGHG106	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_LAMBDA	IMGT (202415-0)
C [auth L]	Fab 1E6	L-LAMBDA	Homo sapiens (human)	IGLV3-2101, IGLJ302, IGLC201, IGLC202, IGLC3*04	V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA	IG	FAB-GAMMA-1_LAMBDA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H]	Heavy Chain	IGHV1	-	lipoprotein gna1870	SAbDab (2024-04-19)
C [auth L]	Light Chain	IGLV3	Lambda	lipoprotein gna1870	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF08794	Factor H binding protein, C-terminal (FHBP_C)	Factor H binding protein, C-terminal	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain c ...	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region [1,5]. This domain is highly similar to Transferrin-binding protein B beta barrel (Pfam:PF01298).	Domain
A [auth D]	PF20937	Factor H binding protein, N-terminal (FHBP_N)	Factor H binding protein, N-terminal	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1,2,3]. The structure of the N-terminal domain ...	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1,2,3]. The structure of the N-terminal domain consists of a more unusual taco-shaped beta-barrel fold characterised by higher intrinsic flexibility than the C-terminal one [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	Lipoprotein GNA1870	-	-	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity
B [auth H]	Heavy chain	-	-	-
C [auth L]	Light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR011250	Outer membrane protein/outer membrane enzyme PagP, beta-barrel	Homologous Superfamily
A [auth D]	IPR014902	Factor H binding protein-like, C-terminal	Domain
A [auth D]	IPR049377	Factor H binding protein, N-terminal	Domain
A [auth D]	IPR049378	Factor H binding protein	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.