6H0E

FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	V-set_8	e6h0eH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
A [auth H]	C1-set_1	e6h0eH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C [auth A]	V-set_8	e6h0eA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth A]	C1-set_1	e6h0eA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
E [auth C]	V-set_8	e6h0eC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
E [auth C]	C1-set_1	e6h0eC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
G [auth E]	V-set_8	e6h0eE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
G [auth E]	C1-set_1	e6h0eE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
B [auth L]	C1-set_4	e6h0eL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth L]	V-set	e6h0eL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D [auth B]	C1-set_4	e6h0eB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
D [auth B]	V-set	e6h0eB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
F [auth D]	C1-set_4	e6h0eD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
F [auth D]	V-set	e6h0eD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
H [auth F]	C1-set_4	e6h0eF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
H [auth F]	V-set	e6h0eF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth H], C [auth A], E [auth C], G [auth E]	Fab dmCBTAU-22.1	VH-CH1	Homo sapiens (human)	IGHV1-206, IGHJ401, IGHJ402, IGHJ403, IGHG1*03	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)
B [auth L], D [auth B], F [auth D], H [auth F]	Fab dmCBTAU-22.1	L-KAPPA	Homo sapiens (human)	IGKV2-2801, IGKV2D-2801, IGKJ101, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], C [auth A], E [auth C], G [auth E]	Heavy Chain	IGHV1	-	microtubule-associated protein tau	SAbDab (2024-04-19)
B [auth L], D [auth B], F [auth D], H [auth F]	Light Chain	IGKV2	Kappa	microtubule-associated protein tau	SAbDab (2024-04-19)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], C [auth A], E [auth C], G [auth E]	HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1	-	-	-
B [auth L], D [auth B], F [auth D], H [auth F]	HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1	-	-	-
I, J [auth G], K [auth J], L [auth K]	Microtubule-associated protein tau	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule lateral binding heat shock protein binding protein-folding chaperone binding SH3 domain binding protein domain specific binding DNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding microtubule lateral binding heat shock protein binding protein-folding chaperone binding SH3 domain binding protein domain specific binding DNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding identical protein binding protein phosphatase binding phosphatase binding enzyme binding protein phosphatase 2A binding Hsp90 protein binding apolipoprotein binding lipoprotein particle binding protein-lipid complex binding kinase binding protein kinase binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular component organization regulation of cellular process regulation of developmental process negative regulation of biological process cellular component organization negative regulation of cellular process anatomical structure development cellular component organization or biogenesis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular component organization regulation of cellular process regulation of developmental process negative regulation of biological process cellular component organization negative regulation of cellular process anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis mitochondrion organization developmental process regulation of biological process negative regulation of cellular component organization negative regulation of developmental process organelle fission biological regulation mitochondrial fission regulation of organelle organization anatomical structure morphogenesis organelle organization negative regulation of organelle organization negative regulation of mitochondrial fission regulation of mitochondrial fission regulation of mitochondrion organization cellular metabolic process reactive oxygen species metabolic process positive regulation of biological process regulation of superoxide metabolic process regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process positive regulation of cellular process negative regulation of membrane potential regulation of mitochondrial membrane potential negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential response to organic substance response to chemical negative regulation of intracellular transport regulation of localization cellular localization transport regulation of transport intracellular transport negative regulation of transport establishment of localization localization regulation of cellular localization establishment of localization in cell regulation of intracellular transport axon extension multicellular organismal process positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization positive regulation of developmental growth system development regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development positive regulation of cellular component organization cellular developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of axonogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size behavior system process learning or memory nervous system process cognition memory protein polymerization protein-containing complex organization microtubule cytoskeleton organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly protein-containing complex assembly microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule-based process regulation of microtubule-based movement microtubule-based movement positive regulation of neuron projection development positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of microtubule polymerization or depolymerization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization regulation of microtubule cytoskeleton organization adult walking behavior adult locomotory behavior adult behavior locomotory behavior walking behavior protein localization negative regulation of establishment of protein localization to mitochondrion establishment of protein localization regulation of protein localization cellular macromolecule localization negative regulation of protein localization regulation of establishment of protein localization negative regulation of establishment of protein localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle macromolecule localization protein localization to organelle protein localization to mitochondrion establishment of protein localization to mitochondrion cell junction organization cell junction assembly synapse organization synapse assembly modulation of chemical synaptic transmission signaling negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling positive regulation of long-term synaptic depression regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling long-term synaptic depression regulation of long-term synaptic depression regulation of cell communication cellular response to heat regulation of cellular response to heat regulation of cellular response to stress response to heat response to temperature stimulus regulation of response to stimulus regulation of response to stress response to abiotic stimulus regulation of protein modification process macromolecule deacylation protein deacetylation regulation of primary metabolic process organic substance metabolic process negative regulation of tubulin deacetylation regulation of protein deacetylation tubulin deacetylation negative regulation of protein modification process protein metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of tubulin deacetylation protein deacylation macromolecule modification macromolecule metabolic process mitochondrion distribution mitochondrion localization organelle localization intracellular distribution of mitochondria protein localization to synapse positive regulation of protein localization to synapse regulation of protein localization to synapse positive regulation of protein localization protein localization to cell junction RNA transport nitrogen compound transport organic substance transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport axo-dendritic transport microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport amyloid fibril formation response to metal ion response to lead ion response to inorganic substance regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling signal transduction neuron migration cell migration cell motility catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process regulation of cellular catabolic process process utilizing autophagic mechanism cellular biosynthetic process negative regulation of cellular metabolic process organic substance biosynthetic process regulation of biosynthetic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process response to nutrient levels response to nutrient protein complex oligomerization protein homooligomerization intrinsic apoptotic signaling pathway in response to oxidative stress cell death apoptotic signaling pathway apoptotic process intrinsic apoptotic signaling pathway programmed cell death establishment of organelle localization organelle transport along microtubule establishment of mitochondrion localization establishment of mitochondrion localization, microtubule-mediated mitochondrion transport along microtubule	membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure axoneme ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection intracellular organelle cell projection cytoskeleton organelle intracellular non-membrane-bounded organelle cytoplasm non-membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen protein-containing complex tubulin complex cytosol somatodendritic compartment dendrite dendritic tree neuron projection neurofibrillary tangle inclusion body axon cell leading edge axolemma plasma membrane membrane leading edge membrane neuron projection membrane cell periphery main axon plasma membrane region cell projection membrane cell body neuronal cell body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton growth cone distal axon axonal growth cone site of polarized growth glial cell projection nuclear periphery membrane microdomain membrane raft cytoplasmic ribonucleoprotein granule ribonucleoprotein granule extracellular region postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
I, J [auth G], K [auth J], L [auth K]	IPR001084	Microtubule associated protein, tubulin-binding repeat	Repeat
I, J [auth G], K [auth J], L [auth K]	IPR027324	Microtubule associated protein MAP2/MAP4/Tau	Family
I, J [auth G], K [auth J], L [auth K]	IPR002955	Microtubule-associated protein Tau	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A [auth H], C [auth A], E [auth C], G [auth E]	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420
I, J [auth G], K [auth J], L [auth K]	SEP	Parent Component: SER RESID: AA0031 , AA0037 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 , O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.