Annotations: 6GY5

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Kelch motif	8084979	3000448	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kelch_1	e6gy5A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Kelch_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.80	Mainly Beta	6 Propeller	Neuraminidase	Kelch-type beta propeller	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01344	Kelch motif (Kelch_1)	Kelch motif	-	Repeat
B [auth U]	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Kelch-like protein 20	protein binding binding interferon binding cytokine binding type II interferon binding cytoskeletal protein binding actin binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death protein localization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process cellular component organization organelle organization cellular component organization or biogenesis cytoskeleton organization protein polyubiquitination protein K33-linked ubiquitination response to organic substance response to interferon-alpha response to stimulus response to chemical response to cytokine Golgi to endosome transport post-Golgi vesicle-mediated transport intracellular transport vesicle-mediated transport cytosolic transport establishment of localization in cell Golgi vesicle transport	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network perinuclear region of cytoplasm axon cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex transferase complex Cul3-RING ubiquitin ligase complex intracellular protein-containing complex nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen PML body nuclear lumen
B [auth U]	Death-associated protein kinase 1	protein serine/threonine kinase activity catalytic activity, acting on a protein calmodulin-dependent protein kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups syntaxin-1 binding protein binding binding SNARE binding syntaxin binding protein serine/threonine kinase activity catalytic activity, acting on a protein calmodulin-dependent protein kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups syntaxin-1 binding protein binding binding SNARE binding syntaxin binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine kinase activity adenyl ribonucleotide binding adenyl nucleotide binding ATP binding calmodulin binding identical protein binding	response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to oxidative stress cellular response to chemical stimulus cellular response to stress response to chemical response to hydroperoxide cellular response to hydroperoxide negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of localization signaling transport regulation of signaling receptor activity regulation of transmembrane transporter activity regulation of signal transduction cell communication regulation of transporter activity localization signal transduction regulation of NMDA receptor activity regulation of monoatomic ion transmembrane transporter activity regulation of signaling regulation of transport establishment of localization transmembrane transport regulation of molecular function regulation of transmembrane transport regulation of response to stimulus regulation of neurotransmitter receptor activity regulation of cell communication positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process regulation of cysteine-type endopeptidase activity regulation of peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway extrinsic apoptotic signaling pathway apoptotic signaling pathway protein phosphorylation protein autophosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process response to organic substance biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cellular response to type II interferon innate immune response cellular response to cytokine stimulus response to external biotic stimulus cellular response to organic substance immune response response to other organism defense response to symbiont response to external stimulus immune system process defense response to other organism autophagic cell death regulation of autophagic cell death positive regulation of autophagic cell death regulation of response to biotic stimulus regulation of response to tumor cell catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process regulation of cellular catabolic process process utilizing autophagic mechanism intracellular signal transduction positive regulation of autophagy positive regulation of cellular metabolic process positive regulation of catabolic process positive regulation of cellular catabolic process	protein kinase complex transferase complex, transferring phosphorus-containing groups DAPK1-calmodulin complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton protein kinase complex transferase complex, transferring phosphorus-containing groups DAPK1-calmodulin complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cell periphery plasma membrane membrane cytoplasm synapse cell junction glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000210	BTB/POZ domain	Domain
A	IPR015915	Kelch-type beta propeller	Homologous Superfamily
A	IPR006652	Kelch repeat type 1	Repeat
A	IPR011705	BTB/Kelch-associated	Domain
A	IPR017096	BTB-kelch protein	Family
A	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
B [auth U]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth U]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B [auth U]	IPR000719	Protein kinase domain	Domain
B [auth U]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth U]	IPR002110	Ankyrin repeat	Repeat
B [auth U]	IPR011029	Death-like domain superfamily	Homologous Superfamily
B [auth U]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth U]	IPR000488	Death domain	Domain
B [auth U]	IPR020676	Death-associated protein kinase 1, catalytic domain	Domain
B [auth U]	IPR020859	Roc domain	Domain
B [auth U]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y2M5	Gaucher disease malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis glioblastoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia large cell medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor
B [auth U]	Pharos: P53355	acute myeloid leukemia non-small cell lung carcinoma renal cell carcinoma myelodysplastic syndrome transitional cell carcinoma peripheral nervous system disease juvenile idiopathic arthritis adenocarcinoma adenoid cystic carcinoma peripheral neuropathy salivary gland adenoid cystic carcinoma sarcomatoid renal cell carcinoma Neoplasms, Second Primary papillary renal cell carcinoma granular cell carcinoma acute myeloid leukemia non-small cell lung carcinoma renal cell carcinoma myelodysplastic syndrome transitional cell carcinoma peripheral nervous system disease juvenile idiopathic arthritis adenocarcinoma adenoid cystic carcinoma peripheral neuropathy salivary gland adenoid cystic carcinoma sarcomatoid renal cell carcinoma Neoplasms, Second Primary papillary renal cell carcinoma granular cell carcinoma tubular adenocarcinoma chromophobe renal cell carcinoma collecting duct carcinoma cystic fibrosis primary myelofibrosis renal carcinoma large cell medulloblastoma medulloblastoma atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease pancreatic intraductal papillary-mucinous neoplasm cribriform carcinoma glioblastoma psoriasis invasive ductal breast carcinoma lung benign neoplasm malignant ependymoma tuberculosis adrenoleukodystrophy oligodendroglioma clear cell renal carcinoma conjunctival disorder pilocytic astrocytoma cribriform carcinoma of breast respiratory system disease salivary gland cancer lung cancer malignant glioma astrocytic tumor brain cancer ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.