6GUT

CRYSTAL STRUCTURE OF NON-TYPEABLE HAEMOPHILUS INFLUENZAE PROTEIN E AND PILA EXPRESSED AS A SINGLE-CHAIN CHIMERIC PROTEIN

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Surface-adhesin protein E-like	8094307	3002209	SCOP2B (2022-06-29)
B	SCOP2 Family	Surface-adhesin protein E	8094306	4004867	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Surface-adhesin protein E-like	8094307	3002209	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00114	e6gutA2	A: a+b two layers	X: Pili subunits (From Topology)	H: Pili subunits (From Topology)	T: Pili subunits	F: PF00114	ECOD (1.6)
A	PF16747	e6gutA1	A: a+b two layers	X: Acidic mitochondrial matrix protein p32-like	H: Protein E (From Topology)	T: Protein E	F: PF16747	ECOD (1.6)
B	PF00114	e6gutB2	A: a+b two layers	X: Pili subunits (From Topology)	H: Pili subunits (From Topology)	T: Pili subunits	F: PF00114	ECOD (1.6)
B	PF16747	e6gutB1	A: a+b two layers	X: Acidic mitochondrial matrix protein p32-like	H: Protein E (From Topology)	T: Protein E	F: PF16747	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.710	Mainly Beta	Beta Barrel	Lipocalin	Surface-adhesin protein E	CATH (utative)
B	2.40.128.710	Mainly Beta	Beta Barrel	Lipocalin	Surface-adhesin protein E	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16747	Surface-adhesin protein E (Adhesin_E)	Surface-adhesin protein E	Adhesin E plays a role in pathogenesis [1]. It binds to host proteins including plasminogen, vitronectin and laminin [2]. The domain consists of a 6-stranded antiparallel beta sheet with an alpha helix at the C terminus tethered to the concave side o ...	Adhesin E plays a role in pathogenesis [1]. It binds to host proteins including plasminogen, vitronectin and laminin [2]. The domain consists of a 6-stranded antiparallel beta sheet with an alpha helix at the C terminus tethered to the concave side of the sheet by a disulfide bridge [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	23S rRNA pseudouridine synthase D,PilA	-	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012902	Prokaryotic N-terminal methylation site	PTM
A, B	IPR045584	Pilin-like	Homologous Superfamily
A, B	IPR043088	Surface-adhesin protein E	Homologous Superfamily
A, B	IPR031939	Surface-adhesin protein E-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.