Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like)8062438 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCell cycle regulatory proteins8098018 3000311 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BPF00134e6gu4B1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: PF00134ECOD (1.6)
BPF02984e6gu4B2 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: PF02984ECOD (1.6)
APF00069e6gu4A1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: PF00069ECOD (1.6)
CPF01111e6gu4C1 A: a+b complex topologyX: Cell cycle regulatory proteins (From Topology)H: Cell cycle regulatory proteins (From Topology)T: Cell cycle regulatory proteinsF: PF01111ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02984Cyclin, C-terminal domain (Cyclin_C)Cyclin, C-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.Domain
PF00134Cyclin, N-terminal domain (Cyclin_N)Cyclin, N-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.Domain
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
PF01111Cyclin-dependent kinase regulatory subunit (CKS)Cyclin-dependent kinase regulatory subunit- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
G2/mitotic-specific cyclin-B1
Cyclin-dependent kinase 1
Cyclin-dependent kinases regulatory subunit 2 -

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP14635
PharosP06493