6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6gffb_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6gffd_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6gfff_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d6gffh_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d6gffk2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
K	d6gffk1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
M	d6gffm_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
L	d6gffl_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
N	d6gffn_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	pro-TGF beta-like	8089966	3002405	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	pro-TGF beta-like	8089966	3002405	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	pro-TGF beta-like	8089966	3002405	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	PF00688	e6gffG1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF00688	ECOD (1.6)
A	PF00688	e6gffA1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF00688	ECOD (1.6)
C	PF00688	e6gffC1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF00688	ECOD (1.6)
E	PF00688	e6gffE1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: PF00688	ECOD (1.6)
B	PF00019	e6gffB1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
D	PF00019	e6gffD1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
F	PF00019	e6gffF1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
H	PF00019	e6gffH1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
I	PF13855	e6gffI2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
J	PF13855	e6gffJ1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
K	PF07654	e6gffK2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
K	PF07686	e6gffK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
M	PF07686	e6gffM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
L	PF07654	e6gffL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
L	PF07686	e6gffL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
N	PF07686	e6gffN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
K	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
L	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
K, M	Fab MHG-8	L-KAPPA	Mus musculus (house mouse)	IGKV13-8501, IGKJ102, IGKC01, IGKC02	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)
L, N	Fab MHG-8	VH-CH1	Mus musculus (house mouse)	IGHV2-6-701, IGHV2-6-702, IGHJ401, IGHG102	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
K, M	Light Chain	IGKV13	Kappa	leucine-rich repeat-containing protein 32 \| transforming growth factor beta-1 \| transforming growth factor beta-1	SAbDab (2024-04-26)
L, N	Heavy Chain	IGHV2	-	leucine-rich repeat-containing protein 32 \| transforming growth factor beta-1 \| transforming growth factor beta-1	SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00688	TGF-beta propeptide (TGFb_propeptide)	TGF-beta propeptide	-	Family
B, D, F, H	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain	-	Domain
I, J	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
I, J	PF01462	Leucine rich repeat N-terminal domain (LRRNT)	Leucine rich repeat N-terminal domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Transforming growth factor beta-1	transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity identical protein binding type II transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding cytokine activity enzyme binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process positive regulation of post-transcriptional gene silencing nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process positive regulation of primary miRNA processing organic substance biosynthetic process positive regulation of post-transcriptional gene silencing by RNA positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of miRNA processing negative regulation of cellular biosynthetic process positive regulation of RNA metabolic process primary miRNA processing regulation of gene expression organic cyclic compound metabolic process miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing miRNA processing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process regulation of miRNA-mediated gene silencing organic substance metabolic process positive regulation of miRNA-mediated gene silencing regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of miRNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of primary miRNA processing regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process reactive oxygen species metabolic process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process superoxide anion generation positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of reactive oxygen species metabolic process heart development circulatory system development immune system development lymph node development immune system process hematopoietic or lymphoid organ development protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport chemotaxis positive regulation of locomotion regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis response to chemical regulation of locomotion locomotion regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of developmental process regulation of tissue remodeling regulation of blood vessel remodeling blood vessel remodeling tissue remodeling regulation of multicellular organismal process regulation of anatomical structure morphogenesis heart valve development heart valve morphogenesis DNA-templated transcription regulation of miRNA metabolic process miRNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process regulation of miRNA transcription cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation cell differentiation regulatory T cell differentiation T cell differentiation leukocyte differentiation regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure lymphocyte mediated immunity regulation of immune effector process immune response to tumor cell negative regulation of immune response to tumor cell negative regulation of lymphocyte mediated immunity response to biotic stimulus negative regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target leukocyte mediated immunity regulation of natural killer cell mediated immune response to tumor cell regulation of immune system process natural killer cell mediated immunity regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity natural killer cell mediated immune response to tumor cell immune effector process regulation of leukocyte mediated immunity defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing regulation of defense response negative regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of response to tumor cell regulation of response to tumor cell response to stress regulation of response to stress innate immune response negative regulation of leukocyte mediated cytotoxicity response to external biotic stimulus negative regulation of cell killing response to tumor cell defense response negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response response to wounding cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of vascular permeability system process circulatory system process positive regulation of vascular permeability vascular process in circulatory system regulation of biological quality blood circulation negative regulation of macrophage cytokine production cytokine production negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of production of molecular mediator of immune response regulation of macrophage cytokine production regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production macrophage cytokine production ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process small molecule metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process connective tissue development skeletal system development chondrocyte differentiation cartilage development organonitrogen compound catabolic process mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process organic substance catabolic process cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of RNA metabolic process fat cell differentiation negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation positive regulation of protein metabolic process positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly cellular component organization or biogenesis regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization regulation of muscle tissue development skeletal muscle tissue development negative regulation of muscle tissue development regulation of skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development negative regulation of skeletal muscle tissue development aortic valve development semi-lunar valve development aortic valve morphogenesis negative regulation of miRNA transcription negative regulation of miRNA metabolic process membrane protein intracellular domain proteolysis proteolysis membrane protein proteolysis regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration cell motility regulation of epithelial cell migration positive regulation of blood vessel endothelial cell migration epithelium migration positive regulation of endothelial cell migration regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation positive regulation of cardiac muscle cell differentiation cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation striated muscle cell differentiation blood vessel morphogenesis vasculogenesis vasculature development blood vessel development embryonic organ development embryonic liver development positive regulation of epithelial cell apoptotic process positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of cytokine production myofibroblast differentiation regulation of leukocyte differentiation positive regulation of nervous system development regulation of neurogenesis regulation of cell development positive regulation of gliogenesis gliogenesis microglia differentiation regulation of macrophage differentiation positive regulation of immune system process regulation of microglia differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation central nervous system development positive regulation of microglia differentiation myeloid leukocyte differentiation regulation of gliogenesis regulation of nervous system development neurogenesis positive regulation of hemopoiesis positive regulation of neurogenesis regulation of multicellular organismal development regulation of myeloid cell differentiation macrophage differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound positive regulation of phosphorylation peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation regulation of localization regulation of protein localization regulation of protein localization to nucleus import into nucleus regulation of protein import into nucleus protein import into nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle regulation of cellular localization protein localization to organelle regulation of intracellular protein transport regulation of inflammatory response positive regulation of inflammatory response positive regulation of defense response inflammatory response response to ketone response to progesterone response to hormone response to steroid hormone response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to oxygen levels response to abiotic stimulus protein-containing complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of cell cycle cell cycle regulation of cell cycle response to sterol response to alcohol response to cholesterol regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth extrinsic apoptotic signaling pathway apoptotic signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway angiogenesis sprouting angiogenesis positive regulation of cell division cell division regulation of cell division positive regulation of establishment of protein localization positive regulation of protein localization to nucleus positive regulation of protein import into nucleus positive regulation of protein localization positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport positive regulation of protein transport positive regulation of intracellular transport positive regulation of transport chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production chemokine production positive regulation of chemokine production mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of epithelial cell migration negative regulation of cell migration negative regulation of cell motility response to organonitrogen compound response to lipoprotein particle response to nitrogen compound cellular response to low-density lipoprotein particle stimulus cellular response to lipoprotein particle stimulus cellular component disassembly negative regulation of extracellular matrix organization extracellular matrix disassembly negative regulation of cellular component organization negative regulation of extracellular matrix disassembly regulation of extracellular matrix disassembly negative regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation ventricular cardiac muscle tissue morphogenesis heart morphogenesis ventricular cardiac muscle tissue development cardiac chamber development cardiac chamber morphogenesis muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II receptor catabolic process cellular catabolic process receptor metabolic process regulation of striated muscle tissue development regulation of muscle organ development negative regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding connective tissue replacement regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of vasculature development positive regulation of vasculature development positive regulation of secretion by cell protein localization to extracellular region regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation negative regulation of biomineral tissue development regulation of biomineral tissue development biomineral tissue development protein dephosphorylation positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation foam cell differentiation macrophage derived foam cell differentiation hematopoietic progenitor cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of immune response positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination DNA metabolic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of DNA metabolic process immunoglobulin production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of immunoglobulin production regulation of isotype switching isotype switching to IgA isotypes somatic diversification of immune receptors via germline recombination within a single locus regulation of lymphocyte activation regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response positive regulation of cell activation positive regulation of leukocyte activation somatic diversification of immune receptors positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response adaptive immune response positive regulation of B cell activation regulation of immunoglobulin production glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process carbohydrate biosynthetic process hyaluronan biosynthetic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process cell junction organization cell-cell junction organization	extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle platelet alpha granule vesicle platelet alpha granule lumen Golgi apparatus Golgi lumen blood microparticle nucleus
B, D, F, H	Transforming growth factor beta-1	transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity identical protein binding type II transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding cytokine activity enzyme binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process positive regulation of post-transcriptional gene silencing nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process positive regulation of primary miRNA processing organic substance biosynthetic process positive regulation of post-transcriptional gene silencing by RNA positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of miRNA processing negative regulation of cellular biosynthetic process positive regulation of RNA metabolic process primary miRNA processing regulation of gene expression organic cyclic compound metabolic process miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing miRNA processing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process regulation of miRNA-mediated gene silencing organic substance metabolic process positive regulation of miRNA-mediated gene silencing regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of miRNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of primary miRNA processing regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process reactive oxygen species metabolic process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process superoxide anion generation positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of reactive oxygen species metabolic process heart development circulatory system development immune system development lymph node development immune system process hematopoietic or lymphoid organ development protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport chemotaxis positive regulation of locomotion regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis response to chemical regulation of locomotion locomotion regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of developmental process regulation of tissue remodeling regulation of blood vessel remodeling blood vessel remodeling tissue remodeling regulation of multicellular organismal process regulation of anatomical structure morphogenesis heart valve development heart valve morphogenesis DNA-templated transcription regulation of miRNA metabolic process miRNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process regulation of miRNA transcription cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation cell differentiation regulatory T cell differentiation T cell differentiation leukocyte differentiation regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure lymphocyte mediated immunity regulation of immune effector process immune response to tumor cell negative regulation of immune response to tumor cell negative regulation of lymphocyte mediated immunity response to biotic stimulus negative regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target leukocyte mediated immunity regulation of natural killer cell mediated immune response to tumor cell regulation of immune system process natural killer cell mediated immunity regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity natural killer cell mediated immune response to tumor cell immune effector process regulation of leukocyte mediated immunity defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing regulation of defense response negative regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of response to tumor cell regulation of response to tumor cell response to stress regulation of response to stress innate immune response negative regulation of leukocyte mediated cytotoxicity response to external biotic stimulus negative regulation of cell killing response to tumor cell defense response negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response response to wounding cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of vascular permeability system process circulatory system process positive regulation of vascular permeability vascular process in circulatory system regulation of biological quality blood circulation negative regulation of macrophage cytokine production cytokine production negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of production of molecular mediator of immune response regulation of macrophage cytokine production regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production macrophage cytokine production ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process small molecule metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process connective tissue development skeletal system development chondrocyte differentiation cartilage development organonitrogen compound catabolic process mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process organic substance catabolic process cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of RNA metabolic process fat cell differentiation negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation positive regulation of protein metabolic process positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly cellular component organization or biogenesis regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization regulation of muscle tissue development skeletal muscle tissue development negative regulation of muscle tissue development regulation of skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development negative regulation of skeletal muscle tissue development aortic valve development semi-lunar valve development aortic valve morphogenesis negative regulation of miRNA transcription negative regulation of miRNA metabolic process membrane protein intracellular domain proteolysis proteolysis membrane protein proteolysis regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration cell motility regulation of epithelial cell migration positive regulation of blood vessel endothelial cell migration epithelium migration positive regulation of endothelial cell migration regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation positive regulation of cardiac muscle cell differentiation cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation striated muscle cell differentiation blood vessel morphogenesis vasculogenesis vasculature development blood vessel development embryonic organ development embryonic liver development positive regulation of epithelial cell apoptotic process positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of cytokine production myofibroblast differentiation regulation of leukocyte differentiation positive regulation of nervous system development regulation of neurogenesis regulation of cell development positive regulation of gliogenesis gliogenesis microglia differentiation regulation of macrophage differentiation positive regulation of immune system process regulation of microglia differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation central nervous system development positive regulation of microglia differentiation myeloid leukocyte differentiation regulation of gliogenesis regulation of nervous system development neurogenesis positive regulation of hemopoiesis positive regulation of neurogenesis regulation of multicellular organismal development regulation of myeloid cell differentiation macrophage differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound positive regulation of phosphorylation peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation regulation of localization regulation of protein localization regulation of protein localization to nucleus import into nucleus regulation of protein import into nucleus protein import into nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle regulation of cellular localization protein localization to organelle regulation of intracellular protein transport regulation of inflammatory response positive regulation of inflammatory response positive regulation of defense response inflammatory response response to ketone response to progesterone response to hormone response to steroid hormone response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to oxygen levels response to abiotic stimulus protein-containing complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of cell cycle cell cycle regulation of cell cycle response to sterol response to alcohol response to cholesterol regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth extrinsic apoptotic signaling pathway apoptotic signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway angiogenesis sprouting angiogenesis positive regulation of cell division cell division regulation of cell division positive regulation of establishment of protein localization positive regulation of protein localization to nucleus positive regulation of protein import into nucleus positive regulation of protein localization positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport positive regulation of protein transport positive regulation of intracellular transport positive regulation of transport chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production chemokine production positive regulation of chemokine production mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of epithelial cell migration negative regulation of cell migration negative regulation of cell motility response to organonitrogen compound response to lipoprotein particle response to nitrogen compound cellular response to low-density lipoprotein particle stimulus cellular response to lipoprotein particle stimulus cellular component disassembly negative regulation of extracellular matrix organization extracellular matrix disassembly negative regulation of cellular component organization negative regulation of extracellular matrix disassembly regulation of extracellular matrix disassembly negative regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation ventricular cardiac muscle tissue morphogenesis heart morphogenesis ventricular cardiac muscle tissue development cardiac chamber development cardiac chamber morphogenesis muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II receptor catabolic process cellular catabolic process receptor metabolic process regulation of striated muscle tissue development regulation of muscle organ development negative regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding connective tissue replacement regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of vasculature development positive regulation of vasculature development positive regulation of secretion by cell protein localization to extracellular region regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation negative regulation of biomineral tissue development regulation of biomineral tissue development biomineral tissue development protein dephosphorylation positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation foam cell differentiation macrophage derived foam cell differentiation hematopoietic progenitor cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of immune response positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination DNA metabolic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of DNA metabolic process immunoglobulin production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of immunoglobulin production regulation of isotype switching isotype switching to IgA isotypes somatic diversification of immune receptors via germline recombination within a single locus regulation of lymphocyte activation regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response positive regulation of cell activation positive regulation of leukocyte activation somatic diversification of immune receptors positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response adaptive immune response positive regulation of B cell activation regulation of immunoglobulin production glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process carbohydrate biosynthetic process hyaluronan biosynthetic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process cell junction organization cell-cell junction organization	extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle platelet alpha granule vesicle platelet alpha granule lumen Golgi apparatus Golgi lumen blood microparticle nucleus
I, J	Leucine-rich repeat-containing protein 32	transforming growth factor beta binding protein binding binding growth factor binding cytokine binding	multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process cytokine production regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process cytokine production regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation negative regulation of cytokine production regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process negative regulation of lymphocyte proliferation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of leukocyte activation regulation of activated T cell proliferation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation developmental process anatomical structure development secondary palate development roof of mouth development positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway response to stimulus cell surface receptor signaling pathway signaling cellular response to transforming growth factor beta stimulus response to endogenous stimulus cell communication cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway signal transduction enzyme-linked receptor protein signaling pathway	cell surface cellular anatomical entity cell periphery plasma membrane membrane extracellular matrix external encapsulating structure extracellular region extracellular space membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cell surface cellular anatomical entity cell periphery plasma membrane membrane extracellular matrix external encapsulating structure extracellular region extracellular space membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
K, M	MHG-8 Fab light chain	-	-	-
L, N	MHG-8 Fab heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR003939	Transforming growth factor beta-1 proprotein	Family
A, C, E, G	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, C, E, G	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A, C, E, G	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A, C, E, G	IPR016319	Transforming growth factor-beta	Family
A, C, E, G	IPR015615	Transforming growth factor-beta-related	Family
A, C, E, G	IPR001111	TGF-beta, propeptide	Domain
B, D, F, H	IPR003939	Transforming growth factor beta-1 proprotein	Family
B, D, F, H	IPR029034	Cystine-knot cytokine	Homologous Superfamily
B, D, F, H	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
B, D, F, H	IPR001839	Transforming growth factor-beta, C-terminal	Domain
B, D, F, H	IPR016319	Transforming growth factor-beta	Family
B, D, F, H	IPR015615	Transforming growth factor-beta-related	Family
B, D, F, H	IPR001111	TGF-beta, propeptide	Domain
I, J	IPR000372	Leucine-rich repeat N-terminal domain	Domain
I, J	IPR001611	Leucine-rich repeat	Repeat
I, J	IPR003591	Leucine-rich repeat, typical subtype	Repeat
I, J	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: P01137	Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma myopathy asthma oral submucous fibrosis calcinosis Duchenne muscular dystrophy endomyocardial fibrosis colorectal cancer Inflammation non-alcoholic fatty liver disease extrahepatic cholestasis occupational asthma osteoarthritis focal segmental glomerulosclerosis diabetic neuropathy Peyronie disease chronic kidney disease tubular adenocarcinoma dry eye syndrome allergic disease posterior leukoencephalopathy syndrome hypertensive disorder ureteral obstruction epilepsy proteinuria inflammatory bowel disease pulmonary emphysema brain disease granular cell carcinoma carcinosarcoma skin cancer diabetic autonomic neuropathy acute lung injury diabetic polyneuropathy hyperplasia urticaria prostate cancer intervertebral disc degenerative disorder pulmonary fibrosis sarcomatoid carcinoma carcinoma acromicric dysplasia skin neoplasm papilloma squamous papilloma adenocarcinoma chronic beryllium disease malignant pancreatic neoplasm alcoholic liver cirrhosis pleural disease chronic obstructive pulmonary disease type 2 diabetes mellitus cirrhosis of liver uremia postmenopausal osteoporosis congenital diaphragmatic hernia Becker muscular dystrophy cribriform carcinoma bipolar disorder schizophrenia depressive disorder glioblastoma lung disease pancreatic ductal adenocarcinoma malignant ependymoma papillomatosis hepatitis maturity-onset diabetes of the young ulcerative colitis primary biliary cholangitis colorectal carcinoma cribriform carcinoma of breast gastric carcinoma cancer lung benign neoplasm osteosarcoma acute kidney failure pancreatic neoplasm heart disease malignant glioma pilocytic astrocytoma medulloblastoma Duchenne and Becker muscular dystrophy pneumonitis undifferentiated carcinoma muscle tissue disease idiopathic interstitial pneumonia atypical teratoid rhabdoid tumor corneal dystrophy geleophysic dysplasia lung carcinoma diabetes mellitus diabetic kidney disease cerebrovascular disorder malignant mesothelioma hepatocellular carcinoma muscular disease astrocytic tumor idiopathic pulmonary fibrosis
B, D, F, H	Pharos: P01137	Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma myopathy asthma oral submucous fibrosis calcinosis Duchenne muscular dystrophy endomyocardial fibrosis colorectal cancer Inflammation non-alcoholic fatty liver disease extrahepatic cholestasis occupational asthma osteoarthritis focal segmental glomerulosclerosis diabetic neuropathy Peyronie disease chronic kidney disease tubular adenocarcinoma dry eye syndrome allergic disease posterior leukoencephalopathy syndrome hypertensive disorder ureteral obstruction epilepsy proteinuria inflammatory bowel disease pulmonary emphysema brain disease granular cell carcinoma carcinosarcoma skin cancer diabetic autonomic neuropathy acute lung injury diabetic polyneuropathy hyperplasia urticaria prostate cancer intervertebral disc degenerative disorder pulmonary fibrosis sarcomatoid carcinoma carcinoma acromicric dysplasia skin neoplasm papilloma squamous papilloma adenocarcinoma chronic beryllium disease malignant pancreatic neoplasm alcoholic liver cirrhosis pleural disease chronic obstructive pulmonary disease type 2 diabetes mellitus cirrhosis of liver uremia postmenopausal osteoporosis congenital diaphragmatic hernia Becker muscular dystrophy cribriform carcinoma bipolar disorder schizophrenia depressive disorder glioblastoma lung disease pancreatic ductal adenocarcinoma malignant ependymoma papillomatosis hepatitis maturity-onset diabetes of the young ulcerative colitis primary biliary cholangitis colorectal carcinoma cribriform carcinoma of breast gastric carcinoma cancer lung benign neoplasm osteosarcoma acute kidney failure pancreatic neoplasm heart disease malignant glioma pilocytic astrocytoma medulloblastoma Duchenne and Becker muscular dystrophy pneumonitis undifferentiated carcinoma muscle tissue disease idiopathic interstitial pneumonia atypical teratoid rhabdoid tumor corneal dystrophy geleophysic dysplasia lung carcinoma diabetes mellitus diabetic kidney disease cerebrovascular disorder malignant mesothelioma hepatocellular carcinoma muscular disease astrocytic tumor idiopathic pulmonary fibrosis
I, J	Pharos: Q14392	pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis adrenal cortex carcinoma asthma breast fibroadenoma endometriosis inflammatory bowel disease lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis allergic rhinitis atopic eczema Crohn disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis adrenal cortex carcinoma asthma breast fibroadenoma endometriosis inflammatory bowel disease lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis allergic rhinitis atopic eczema Crohn disease gastroesophageal reflux disease interstitial cystitis lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis alopecia areata breast cancer cystic fibrosis herpes zoster lung adenocarcinoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.