6GCT

cryo-EM structure of the human neutral amino acid transporter ASCT2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Proton glutamate symport protein	8099182	3001772	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Proton glutamate symport protein	8099182	3001772	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Proton glutamate symport protein	8099182	3001772	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00375	e6gctA1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: PF00375	ECOD (1.6)
B	PF00375	e6gctB1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: PF00375	ECOD (1.6)
C	PF00375	e6gctC1	A: alpha complex topology	X: Proton glutamate symport protein (From Topology)	H: Proton glutamate symport protein (From Topology)	T: Proton glutamate symport protein	F: PF00375	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00375	Sodium:dicarboxylate symporter family (SDF)	Sodium:dicarboxylate symporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Neutral amino acid transporter B(0)	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity antiporter activity active transmembrane transporter activity transporter activity transmembrane transporter activity secondary active transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity organic cation transmembrane transporter activity protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity antiporter activity active transmembrane transporter activity transporter activity transmembrane transporter activity secondary active transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity organic cation transmembrane transporter activity L-glutamine transmembrane transporter activity neutral L-amino acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity organic anion transmembrane transporter activity L-aspartate transmembrane transporter activity C4-dicarboxylate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity acidic amino acid transmembrane transporter activity symporter activity L-serine transmembrane transporter activity ligand-gated channel activity gated channel activity passive transmembrane transporter activity channel activity cation binding ion binding metal ion binding small molecule binding	import into cell nitrogen compound transport carboxylic acid transmembrane transport transport aspartate transmembrane transport amino acid transmembrane transport L-amino acid transport C4-dicarboxylate transport localization organic acid transmembrane transport organic anion transport carboxylic acid transport organic substance transport import across plasma membrane import into cell nitrogen compound transport carboxylic acid transmembrane transport transport aspartate transmembrane transport amino acid transmembrane transport L-amino acid transport C4-dicarboxylate transport localization organic acid transmembrane transport organic anion transport carboxylic acid transport organic substance transport import across plasma membrane establishment of localization organic acid transport transmembrane transport amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport cellular process amino acid import across plasma membrane L-aspartate import across plasma membrane L-aspartate transmembrane transport neutral amino acid transport glutamine secretion glutamine transport secretion export from cell secretion by cell developmental process multicellular organismal process cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis system process circulatory system process vascular process in circulatory system vascular transport transport across blood-brain barrier L-glutamine import across plasma membrane organic cation transport	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR018107	Sodium:dicarboxylate symporter, conserved site	Conserved Site
A, B, C	IPR036458	Sodium:dicarboxylate symporter superfamily	Homologous Superfamily
A, B, C	IPR001991	Sodium:dicarboxylate symporter	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q15758	attention deficit hyperactivity disorder, inattentive type lung cancer rheumatoid arthritis B-cell chronic lymphocytic leukemia malignant mesothelioma schizophrenia interstitial cystitis medulloblastoma sclerosing cholangitis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	Dicarboxylate/amino acid:Cation Symporter (DAACS)	Proton glutamate symport protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier (SLC) Transporter Superfamily	Neutral amino acid transporter ASCT2, inward-oriented state

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.