Annotations: 6G9L

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13855	e6g9lA2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
A	PF12534	e6g9lA1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)
B	PF13855	e6g9lB2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
B	PF12534	e6g9lB1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)
C	PF13855	e6g9lC2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
C	PF12534	e6g9lC1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)
D	PF13855	e6g9lD2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
D	PF12534	e6g9lD1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)
E	PF13855	e6g9lE2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
E	PF12534	e6g9lE1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)
F	PF13855	e6g9lF2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
F	PF12534	e6g9lF1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: PF12534	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF12534	Pannexin-like TM region of LRRC8 (Pannexin_like)	Pannexin-like TM region of LRRC8	-	Family
A, B, C, D, E A, B, C, D, E, F	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Volume-regulated anion channel subunit LRRC8A	volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity nucleotide transmembrane transporter activity guanine nucleotide transmembrane transporter activity purine ribonucleotide transmembrane transporter activity adenine nucleotide transmembrane transporter activity purine nucleotide transmembrane transporter activity volume-sensitive anion channel activity monoatomic anion transmembrane transporter activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity nucleotide transmembrane transporter activity guanine nucleotide transmembrane transporter activity purine ribonucleotide transmembrane transporter activity adenine nucleotide transmembrane transporter activity purine nucleotide transmembrane transporter activity carbohydrate derivative transmembrane transporter activity nucleobase-containing compound transmembrane transporter activity cyclic-GMP-AMP transmembrane transporter activity organophosphate ester transmembrane transporter activity organic anion transmembrane transporter activity identical protein binding protein binding binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation cellular process myoblast differentiation positive regulation of cellular process transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport cellular component organization cellular component biogenesis protein hexamerization cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular component organization or biogenesis regulation of cellular component size cell volume homeostasis regulation of biological quality regulation of cell size regulation of anatomical structure size multicellular organismal process immature B cell differentiation hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation pre-B cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transport carboxylic acid transmembrane transport aspartate transmembrane transport organic substance transport amino acid transmembrane transport C4-dicarboxylate transport organic acid transport amino acid transport dicarboxylic acid transport cellular response to stimulus response to stimulus signaling signal transduction cell communication import into cell guanine nucleotide transmembrane transport nucleotide transport carbohydrate derivative transport purine nucleotide transport adenine nucleotide transport cyclic-GMP-AMP transmembrane import across plasma membrane guanine nucleotide transport nucleobase-containing compound transport purine-containing compound transmembrane transport purine ribonucleotide transport import across plasma membrane nucleotide transmembrane transport cyclic nucleotide transport organophosphate ester transport protein localization positive regulation of cell communication regulation of localization establishment of protein localization positive regulation of establishment of protein localization cellular macromolecule localization positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion positive regulation of protein localization cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion positive regulation of signaling response to osmotic stress response to stress response to abiotic stimulus taurine transmembrane transport alkanesulfonate transmembrane transport sulfur compound transport	membrane cellular anatomical entity cell surface cell periphery plasma membrane vacuolar membrane membrane-bounded organelle intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle membrane cellular anatomical entity cell surface cell periphery plasma membrane vacuolar membrane membrane-bounded organelle intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm organelle membrane lysosome protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR001611	Leucine-rich repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR021040	LRRC8, pannexin-like TM region	Domain
A, B, C, D, E A, B, C, D, E, F	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Other Ion Channels	LRRC8A volume-regulated anion channel

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.